Welcome to SCOP2!

Antonina Andreeva, Dave Howorth, Cyrus Chothia, Eugene Kulesha, Alexey Murzin, SCOP2 prototype: a new approach to protein structure mining (2014) Nucl. Acid Res., 42 (D1): D310-D314. [PDF]

Description of the SCOP2 database

SCOP2 is a successor of Structural classification of proteins (SCOP). Similarly to SCOP, the main focus of SCOP2 is on proteins that are structurally characterized and deposited in the PDB. Proteins are organized according to their structural and evolutionary relationships, but, in contrast to SCOP, instead of a simple tree-like hierarchy these relationships form a complex network of nodes. Each node represents a relationship of a particular type and is exemplified by a region of protein structure and sequence.

In SCOP2, we try to put in use the knowledge we acquired over the past years and the lessons we have learned during the classification of protein structures. We believe that there are many peculiarities of proteins and their structures that have been missed due to the constraints of the original SCOP hierarchical schema. We hope that our users will find the new resource useful and that it could open new avenues for protein analysis and research.

Quick introduction on how to browse, search and download

SCOP2 offers two different ways for accessing data: SCOP2-browser, that allows navigation through the SCOP2 classification in a traditional way by browsing pages displaying the node information, and SCOP2-graph, which is a graph-based web tool for display and navigation through the SCOP2 classification. Both tools provide search of SCOP2 data by free text, node names, IDs, tags and keywords, as well as external identifiers associated with them, e.g. PDB and UniProt. SCOP2 data can also be retrieved via REST interface or downloaded from the SCOP2 Download page. For more information visit the About page.

Web browser compatibility check

To test whether your web browser and its settings are suitable to view SCOP2-graph and to visualize protein structures using Jmol applet click here.

Information about the release

This is a beta release and contains a fraction of protein structure data. We wish to introduce the new database to our users and seek for a comprehensive feedback that would guide us for the future database development and expansion. We plan to regularly update the site with new classification data.