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proteins with segregated alpha-helices and beta-strands

Derived from SCOP 53931

## Class

class Alpha and beta proteins (a+b) (1000003)proteins with segregated alpha-helices and beta-strands

Derived from SCOP 53931

## Children

- fold SD/FR insert domain-like fold (2000007)

beta(2)-alpha-beta-alpha(n)-beta-alpha(n)-beta; antiparallel beta-sheet, order: 21543, folded into half-barrel and capped at both ends with helices

Derived from SCOP 56424 - fold LDH C-terminal subdomain-like fold (2000008)

alpha-beta(3)-alpha, meander beta-sheet twisted into a half-barrel, order 123, with helices packed at the opposite ends

Derived from SCOP 56326 - fold Ferredoxin-like (2000014)

beta-alpha-beta(2)-alpha-beta; 2 layers, a/b; antiparallel beta-sheet, order: 4132

Derived from SCOP 54861 - fold Folate-binding halfdomain-like (2000017)

beta(2)-alpha-beta(3)-alpha; 2 layers, alpha/beta, antiparallel beta-sheet, order: 12543

Derived from SCOP 103024 - fold GSR C-terminal domain-like (2000020)

extended variant of SufE/NifU-like fold: beta(5)-alpha(3), 2 layers, a/b; antiparallel beta-sheet, order 12543

Derived from SCOP 55423 - fold Flavoreductase insert-domain like (2000026)

beta(4)-alpha-beta; 2 layers, a/b; antiparallel beta-sheet, order: 51432

Derived from SCOP 54372 - fold TrkA C-terminal domain-like (2000029)

beta-X-beta(2)-X-beta-alpha; antiparallel beta-sheet, order: 1423, folded into a half barrel and capped by helix at one end; topological similarity to the HPr-like fold

Derived from SCOP 116725 - fold Canonical FwdE/GAPDH domain-like fold (2000032)

alpha-beta-alpha-beta(3), 2 layers, alpha/beta sandwich, mixed sheet: 2134, strand 2 is parallel to strand 1, psi-loop between strands 2 and 3

Derived from SCOP 55346 - fold Class II aaRS/BPL domain-like (2000038)

core: beta-X-beta(2)-alpha-beta(4); mixed, mostly antiparallel beta-sheet, order 1237654, strands 1 and 2 are parallel to each other

Derived from SCOP 55680 - fold GyrI-type alpha(2),beta(6)-barrel (2000042)

duplication of beta-alpha-beta(2) motif: antiparallel beta sheet forms barrel (n=6, S=12), strand order 132564 (anticlockwise)

Derived from SCOP 55135 - fold Protein kinase-like (PK-like) (2000046)

consists of two alpha+beta subdomains that sandwich the ATP binding site

Derived from SCOP 56111 - fold Profilin-like (2000047)

core: beta(2)-alpha(n)-beta(3); antiparallel beta-sheet, order: 21543, 2 layers: a/b; extra N-terminal and/or C-terminal helices form third layer

Derived from SCOP 55769 - fold Chorismate lyase-like (2000052)

duplication of alpha(2)-beta(3) motif, antiparallel beta sheet, order 123654

Derived from SCOP 64287 - fold Cytochrome b5-like (2000053)

beta-alpha-beta(2)-alpha(1,2)-(beta)-alpha(2)-beta, 3 layers: a/b/a, antiparallel beta-sheet, order: 1532(4)

Derived from SCOP 55855 - fold Urocanase catalytic domain-like (2000054)

alpha(2)-beta(3)-X-beta-alpha(2)-beta-alpha-beta-alpha-beta(2)-alpha, X is the insertion of a Rossmann-like domain; 3 layers, a/b/a; mixed beta-sheet, order:21378645, strands 2, 4 and 8 are antiparallel to the rest

Derived from SCOP 111325 - fold NosL/MerB-like (2000057)

unusual fold, comprises two structural repeats of beta(2)-alpha-beta motifs, forming separate beta-sheets, probable duplication

Derived from SCOP 160386 - fold GHKL domain-like (2000066)

2 layers: alpha/beta; 8-stranded mixed beta-sheet, order: 87126345, strands 1 and 7 are parallel to each other

Derived from SCOP 55873 - fold DCoH-like (2000068)

beta(2)-alpha-beta(2)-alpha, 2 layers, alpha/beta; antiparallel beta-sheet, order 1243

Derived from SCOP 55247 - fold ATP-grasp platform-like (2000069)

beta(3)-alpha-beta(2); 2 layers, a/b; antiparallel beta-sheet, order: 32145

Derived from SCOP 56058 - fold "Reversed" ferredoxin-like fold (2000156)

beta-alpha-beta(2)-alpha-beta; 2 layers, a/b; antiparallel beta-sheet, order: 1423

Derived from SCOP 100878 - fold Pili subunit-like (2000070)

alpha-beta(4); 2 layers, a/b, helix is packed along the strands of antiparallel beta-sheet, order 1234, meander

Derived from SCOP 54522 - fold Nudix (2000071)

beta(3)-alpha-beta(3)-alpha, 3 layers: alpha/beta/alpha, mixed beta-sheet, order: 6(2,3)154, strands 1 and 5 are parallel to each other; contains bifurcation: strands 2 and 3 both H-bond to strands 1; topological similarity to beta-grasp motif

Derived from SCOP 55810 - fold Ribosomal protein S5 domain 2-like (2000072)

core: beta(3)-alpha-beta-alpha, 2 layers: alpha/beta, mixed beta sheet, order: 1243, strand 2 is antiparallel to the rest; psi-loop between strands 2 and 3; left-handed crossover between strands 3 and 4

Derived from SCOP 54210 - fold Type II GAT domain-like (2000081)

beta-alpha-beta(2)-alpha-beta(7)-alpha-beta(3); 4 layers: alpha/beta/beta/alpha, 13 strands in two antiparallel beta-sheets; S1 order: 3241A9B; S2 order: 5678CD

Derived from SCOP 56234 - fold CBS-domain pair (2000093)

duplication: tandem repeat of two beta-X-beta-alpha-beta(2)-alpha motifs of similar sequences, 4 layers: a/b/b/a

Derived from SCOP 54630 - fold HPr-like (2000096)

beta-alpha-beta(2)-alpha-beta-alpha, 2 layers: a/b, antiparallel sheet 1423

Derived from SCOP 55593 - fold beta-Grasp (2000097)

core: beta(2)-alpha-beta(2), 2 layers, a/b; mixed beta-sheet, order: 2143, strands 1 and 4 are parallel to each other

Derived from SCOP 54235 - fold Creatinase/aminopeptidase catalytic domain-like (2000099)

duplication: composed of two very similar alpha(2)-beta(3) units related by a pseudo twofold axis; unusual pairing of the two beta-sheets at a "wrong" positive angle and few H-bonds between the edge strands

Derived from SCOP 55919 - fold Circularly permuted folate-binding halfdomain-like (2000106)

beta-alpha-beta(3)-alpha-beta; 2 layers, alpha/beta, antiparallel beta-sheet, order: 51432

Derived from SCOP 103024 - fold Enolase N-terminal domain-like (2000109)

beta(3)-alpha(3); 2 layers, a/b; meander antiparallel beta-sheet, order: 123, packed against a 3-helical bundle

Derived from SCOP 54825 - fold FUR dimerisation domain-like (2000111)

dimer of beta(2)-alpha-beta units; mixed beta-sheet, order 213, strand 2 is antiparallel to the rest; forms a single beta-sheet in the dimer with antiparallel H-bonding of strands 3 and 3' - fold Nucleotidyltransferase-like (2000113)

to be split into different fold variants; core: alpha-beta-turn-beta-X-beta-(alpha); mixed beta-sheet, order: 123, strand 1 is antiparallel to the rest

Derived from SCOP 81302 - fold Frataxin-like (2000119)

alpha-beta(5)-alpha; 2 layers: alpha/beta; meander antiparallel sheet, order 12345

Derived from SCOP 55382 - fold E2 binding domain-like (2000122)

beta-alpha-beta(2)-X-beta(2), 2 layers, a/b; antiparallel beta-sheet 15423

Circularly permuted variant of the ubiqutin-like topology; the C-terminal strand occupies the position of the N-terminal strand of the ubiquitin-like proteins but runs in the opposite direction - fold RRF domain-like (2000125)

alpha-beta(2)-alpha-beta(2); 2 layers, a/b; antiparallel beta-sheet, order: 1243

Derived from SCOP 55185 - fold SCP-like (2000129)

alpha-beta(3)-X-beta-alpha(2)-beta-alpha; 2 layers: a/b, crossover loop X makes the third layer; antiparallel beta-sheet of 5 strands; order: 32145

Derived from SCOP 55717 - fold 'Hot dog' fold (2000130)

core: beta-alpha-beta(4); 2 layers, a/b; antiparallel beta-sheet, order 13452

Derived from SCOP 54636 - fold Lambda cro protein-like (2000131)

beta-alpha(3)-beta(2); 2 layers: a/b; antiparallel beta-sheet, order 123; the three helices retain similar arrangement to the first three helices of the p22 cro protein-like fold, including HTH motif - fold Mad2-like (2000132)

core: alpha(2)-beta(2)-alpha-beta; mixed sheet, order: 213

Derived from SCOP 56018 - fold beta-hairpin-alpha-hairpin repeat (2000134)

multiple repeats of beta(2)-alpha(2) motif

Derived from SCOP 74651 - fold Pseudo "winged helix" (2000135)

beta-alpha(2)-beta(2)-alpha; architecture is similar to that of the "winged helix" fold but topology is different

Derived from SCOP 46954 - fold IL8-like (2000141)

beta(3)-alpha; 2 layers, a/b; meander antiparallel beta-sheet, order: 123, helix is packed across the beta-strands

Derived from SCOP 54116 - fold Canonical WHD (winged helix domain) fold (2000144)

alpha(3)-beta(2); 3-helical DRBD-type bundle, capped at one end with a beta-haipin; may contain extra beta-strand in the loop, connecting helices 1 and 2 - fold Helix-extended WHD fold (2000145)

alpha(3)-beta(2)-alpha; 3-helical DRBD-type bundle, capped at one end with a beta-haipin and helix 4 - fold Sheet-extended WHD fold (2000146)

alpha-beta(2)-alpha(2)-beta(2); 3-helical DRBD-type bundle, capped at one end with a 4-stranded beta-sheet - fold Variant WHD fold (2000147)

not a true fold: comprises different variants of WHD-like folds due to variations in sizes of the canonical WHD secondary structures and/or insertions of extra structures - fold Variant FwdE/GAPDH domain-like fold (2000150)

not a true fold: different evolutionary elaborations of canonical FwdE/GAPDH domain-like fold

Derived from SCOP 55346 - fold Variant Rossmann fold (2000151)

not a true fold: other evolutionary elaborations of a canonical Rossmann fold, which are not conserved in a superfamily

Derived from SCOP 56326 - fold MptD-like (2000163)

alpha(2)-beta(4); 2 layers: a/b; antiparallel beta-sheet, order: 1234, meander

Derived from SCOP 143559 - fold Canonical cyclophilin-type beta(8)-barrel (2000164)

barrel, closed; n=8, S=10; antiparallel beta-sheet, clockwise order: 12756438, complex topology with two overside connections that cross each other

Derived from SCOP 50890 - fold Cyclophilin38-type double beta-barrel (2000165)

Bifurcated beta-sheet of 9 strands folded into two conjoint barrels; barrel 1: closed; n=8, S=10; antiparallel beta-sheet, anticlockwise order: 12659348; barrel 2: closed n=6, S=10; mixed beta-sheet, clockwise order: 126578, strands 7 and 8 are parallel to each other

Derived from SCOP 50890 - fold FAD-binding/transporter-associated domain-like (2000573)

consists of two alpha+beta subdomains

Derived from SCOP 56175 - fold Anti-LPS factor/recA domain (2000610)

alpha-beta(3)-alpha(2), 2 layers, alpha/beta

Derived from SCOP 54751 - fold RbfA-like (2000652)

formerly: Alpha-lytic protease prodomain-like; alpha-beta(2)-(alpha)-beta, 2 layers: alpha/beta, mixed beta-sheet, order 123, strand 1 is antiparallel to the rest

Derived from SCOP 54805 - fold Obg protein C-terminal domain-like (2000732)

beta-(2)-alpha(3)-beta(2), 2 layers: beta/alpha, mixed beta-sheet: order 1234, strands 2 and 3 a parallel to each other

Derived from SCOP 102740 - fold CobW C-terminal domain-like (2000788)

beta-alpha-beta(4)-alpha, 2 layers: a/b, antiparallel sheet 15234, topological similarity to the HPr-like fold

Derived from SCOP 90001 - fold MutS N-terminal domain-like (2001031)

beta(2)-alpha-beta(2)-alpha-beta(2), 2 layers, alpha/beta

Derived from SCOP 55266 - fold MalF P2 linker domain-like (2001253)

alpha-beta(5); 2 layers; meander 5-stranded beta-sheet is folded into a half-barrel

Derived from SCOP 160963 - fold UvrA UvrB-binding domain-like (2001256)

alpha-beta-alpha-beta(2)-X-beta-alpha-beta(2); two layers: a/b; antiparallel beta sheet of six strands, order: 651423; internal pseudo twofold symmetry - fold P-loop kinase-like (2001257)

3 layers: a/b/a; parallel beta sheet of five strands, order: 23145