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Class

class Alpha and beta proteins (a+b) (1000003)
proteins with segregated alpha-helices and beta-strands
Derived from SCOP 53931

Children

  • fold SD/FR insert domain-like fold (2000007)
    beta(2)-alpha-beta-alpha(n)-beta-alpha(n)-beta; antiparallel beta-sheet, order: 21543, folded into half-barrel and capped at both ends with helices
    Derived from SCOP 56424
  • fold LDH C-terminal subdomain-like fold (2000008)
    alpha-beta(3)-alpha, meander beta-sheet twisted into a half-barrel, order 123, with helices packed at the opposite ends
    Derived from SCOP 56326
  • fold Ferredoxin-like (2000014)
    beta-alpha-beta(2)-alpha-beta; 2 layers, a/b; antiparallel beta-sheet, order: 4132
    Derived from SCOP 54861
  • fold Folate-binding halfdomain-like (2000017)
    beta(2)-alpha-beta(3)-alpha; 2 layers, alpha/beta, antiparallel beta-sheet, order: 12543
    Derived from SCOP 103024
  • fold GSR C-terminal domain-like (2000020)
    extended variant of SufE/NifU-like fold: beta(5)-alpha(3), 2 layers, a/b; antiparallel beta-sheet, order 12543
    Derived from SCOP 55423
  • fold Flavoreductase insert-domain like (2000026)
    beta(4)-alpha-beta; 2 layers, a/b; antiparallel beta-sheet, order: 51432
    Derived from SCOP 54372
  • fold TrkA C-terminal domain-like (2000029)
    beta-X-beta(2)-X-beta-alpha; antiparallel beta-sheet, order: 1423, folded into a half barrel and capped by helix at one end; topological similarity to the HPr-like fold
    Derived from SCOP 116725
  • fold Canonical FwdE/GAPDH domain-like fold (2000032)
    alpha-beta-alpha-beta(3), 2 layers, alpha/beta sandwich, mixed sheet: 2134, strand 2 is parallel to strand 1, psi-loop between strands 2 and 3
    Derived from SCOP 55346
  • fold Class II aaRS/BPL domain-like (2000038)
    core: beta-X-beta(2)-alpha-beta(4); mixed, mostly antiparallel beta-sheet, order 1237654, strands 1 and 2 are parallel to each other
    Derived from SCOP 55680
  • fold GyrI-type alpha(2),beta(6)-barrel (2000042)
    duplication of beta-alpha-beta(2) motif: antiparallel beta sheet forms barrel (n=6, S=12), strand order 132564 (anticlockwise)
    Derived from SCOP 55135
  • fold Protein kinase-like (PK-like) (2000046)
    consists of two alpha+beta subdomains that sandwich the ATP binding site
    Derived from SCOP 56111
  • fold Profilin-like (2000047)
    core: beta(2)-alpha(n)-beta(3); antiparallel beta-sheet, order: 21543, 2 layers: a/b; extra N-terminal and/or C-terminal helices form third layer
    Derived from SCOP 55769
  • fold Chorismate lyase-like (2000052)
    duplication of alpha(2)-beta(3) motif, antiparallel beta sheet, order 123654
    Derived from SCOP 64287
  • fold Cytochrome b5-like (2000053)
    beta-alpha-beta(2)-alpha(1,2)-(beta)-alpha(2)-beta, 3 layers: a/b/a, antiparallel beta-sheet, order: 1532(4)
    Derived from SCOP 55855
  • fold Urocanase catalytic domain-like (2000054)
    alpha(2)-beta(3)-X-beta-alpha(2)-beta-alpha-beta-alpha-beta(2)-alpha, X is the insertion of a Rossmann-like domain; 3 layers, a/b/a; mixed beta-sheet, order:21378645, strands 2, 4 and 8 are antiparallel to the rest
    Derived from SCOP 111325
  • fold NosL/MerB-like (2000057)
    unusual fold, comprises two structural repeats of beta(2)-alpha-beta motifs, forming separate beta-sheets, probable duplication
    Derived from SCOP 160386
  • fold GHKL domain-like (2000066)
    2 layers: alpha/beta; 8-stranded mixed beta-sheet, order: 87126345, strands 1 and 7 are parallel to each other
    Derived from SCOP 55873
  • fold DCoH-like (2000068)
    beta(2)-alpha-beta(2)-alpha, 2 layers, alpha/beta; antiparallel beta-sheet, order 1243
    Derived from SCOP 55247
  • fold ATP-grasp platform-like (2000069)
    beta(3)-alpha-beta(2); 2 layers, a/b; antiparallel beta-sheet, order: 32145
    Derived from SCOP 56058
  • fold "Reversed" ferredoxin-like fold (2000156)
    beta-alpha-beta(2)-alpha-beta; 2 layers, a/b; antiparallel beta-sheet, order: 1423
    Derived from SCOP 100878
  • fold Pili subunit-like (2000070)
    alpha-beta(4); 2 layers, a/b, helix is packed along the strands of antiparallel beta-sheet, order 1234, meander
    Derived from SCOP 54522
  • fold Nudix (2000071)
    beta(3)-alpha-beta(3)-alpha, 3 layers: alpha/beta/alpha, mixed beta-sheet, order: 6(2,3)154, strands 1 and 5 are parallel to each other; contains bifurcation: strands 2 and 3 both H-bond to strands 1; topological similarity to beta-grasp motif
    Derived from SCOP 55810
  • fold Ribosomal protein S5 domain 2-like (2000072)
    core: beta(3)-alpha-beta-alpha, 2 layers: alpha/beta, mixed beta sheet, order: 1243, strand 2 is antiparallel to the rest; psi-loop between strands 2 and 3; left-handed crossover between strands 3 and 4
    Derived from SCOP 54210
  • fold Type II GAT domain-like (2000081)
    beta-alpha-beta(2)-alpha-beta(7)-alpha-beta(3); 4 layers: alpha/beta/beta/alpha, 13 strands in two antiparallel beta-sheets; S1 order: 3241A9B; S2 order: 5678CD
    Derived from SCOP 56234
  • fold CBS-domain pair (2000093)
    duplication: tandem repeat of two beta-X-beta-alpha-beta(2)-alpha motifs of similar sequences, 4 layers: a/b/b/a
    Derived from SCOP 54630
  • fold HPr-like (2000096)
    beta-alpha-beta(2)-alpha-beta-alpha, 2 layers: a/b, antiparallel sheet 1423
    Derived from SCOP 55593
  • fold beta-Grasp (2000097)
    core: beta(2)-alpha-beta(2), 2 layers, a/b; mixed beta-sheet, order: 2143, strands 1 and 4 are parallel to each other
    Derived from SCOP 54235
  • fold Creatinase/aminopeptidase catalytic domain-like (2000099)
    duplication: composed of two very similar alpha(2)-beta(3) units related by a pseudo twofold axis; unusual pairing of the two beta-sheets at a "wrong" positive angle and few H-bonds between the edge strands
    Derived from SCOP 55919
  • fold Circularly permuted folate-binding halfdomain-like (2000106)
    beta-alpha-beta(3)-alpha-beta; 2 layers, alpha/beta, antiparallel beta-sheet, order: 51432
    Derived from SCOP 103024
  • fold Enolase N-terminal domain-like (2000109)
    beta(3)-alpha(3); 2 layers, a/b; meander antiparallel beta-sheet, order: 123, packed against a 3-helical bundle
    Derived from SCOP 54825
  • fold FUR dimerisation domain-like (2000111)
    dimer of beta(2)-alpha-beta units; mixed beta-sheet, order 213, strand 2 is antiparallel to the rest; forms a single beta-sheet in the dimer with antiparallel H-bonding of strands 3 and 3'
  • fold Nucleotidyltransferase-like (2000113)
    to be split into different fold variants; core: alpha-beta-turn-beta-X-beta-(alpha); mixed beta-sheet, order: 123, strand 1 is antiparallel to the rest
    Derived from SCOP 81302
  • fold Frataxin-like (2000119)
    alpha-beta(5)-alpha; 2 layers: alpha/beta; meander antiparallel sheet, order 12345
    Derived from SCOP 55382
  • fold E2 binding domain-like (2000122)
    beta-alpha-beta(2)-X-beta(2), 2 layers, a/b; antiparallel beta-sheet 15423
    Circularly permuted variant of the ubiqutin-like topology; the C-terminal strand occupies the position of the N-terminal strand of the ubiquitin-like proteins but runs in the opposite direction
  • fold RRF domain-like (2000125)
    alpha-beta(2)-alpha-beta(2); 2 layers, a/b; antiparallel beta-sheet, order: 1243
    Derived from SCOP 55185
  • fold SCP-like (2000129)
    alpha-beta(3)-X-beta-alpha(2)-beta-alpha; 2 layers: a/b, crossover loop X makes the third layer; antiparallel beta-sheet of 5 strands; order: 32145
    Derived from SCOP 55717
  • fold 'Hot dog' fold (2000130)
    core: beta-alpha-beta(4); 2 layers, a/b; antiparallel beta-sheet, order 13452
    Derived from SCOP 54636
  • fold Lambda cro protein-like (2000131)
    beta-alpha(3)-beta(2); 2 layers: a/b; antiparallel beta-sheet, order 123; the three helices retain similar arrangement to the first three helices of the p22 cro protein-like fold, including HTH motif
  • fold Mad2-like (2000132)
    core: alpha(2)-beta(2)-alpha-beta; mixed sheet, order: 213
    Derived from SCOP 56018
  • fold beta-hairpin-alpha-hairpin repeat (2000134)
    multiple repeats of beta(2)-alpha(2) motif
    Derived from SCOP 74651
  • fold Pseudo "winged helix" (2000135)
    beta-alpha(2)-beta(2)-alpha; architecture is similar to that of the "winged helix" fold but topology is different
    Derived from SCOP 46954
  • fold IL8-like (2000141)
    beta(3)-alpha; 2 layers, a/b; meander antiparallel beta-sheet, order: 123, helix is packed across the beta-strands
    Derived from SCOP 54116
  • fold Canonical WHD (winged helix domain) fold (2000144)
    alpha(3)-beta(2); 3-helical DRBD-type bundle, capped at one end with a beta-haipin; may contain extra beta-strand in the loop, connecting helices 1 and 2
  • fold Helix-extended WHD fold (2000145)
    alpha(3)-beta(2)-alpha; 3-helical DRBD-type bundle, capped at one end with a beta-haipin and helix 4
  • fold Sheet-extended WHD fold (2000146)
    alpha-beta(2)-alpha(2)-beta(2); 3-helical DRBD-type bundle, capped at one end with a 4-stranded beta-sheet
  • fold Variant WHD fold (2000147)
    not a true fold: comprises different variants of WHD-like folds due to variations in sizes of the canonical WHD secondary structures and/or insertions of extra structures
  • fold Variant FwdE/GAPDH domain-like fold (2000150)
    not a true fold: different evolutionary elaborations of canonical FwdE/GAPDH domain-like fold
    Derived from SCOP 55346
  • fold Variant Rossmann fold (2000151)
    not a true fold: other evolutionary elaborations of a canonical Rossmann fold, which are not conserved in a superfamily
    Derived from SCOP 56326
  • fold MptD-like (2000163)
    alpha(2)-beta(4); 2 layers: a/b; antiparallel beta-sheet, order: 1234, meander
    Derived from SCOP 143559
  • fold Canonical cyclophilin-type beta(8)-barrel (2000164)
    barrel, closed; n=8, S=10; antiparallel beta-sheet, clockwise order: 12756438, complex topology with two overside connections that cross each other
    Derived from SCOP 50890
  • fold Cyclophilin38-type double beta-barrel (2000165)
    Bifurcated beta-sheet of 9 strands folded into two conjoint barrels; barrel 1: closed; n=8, S=10; antiparallel beta-sheet, anticlockwise order: 12659348; barrel 2: closed n=6, S=10; mixed beta-sheet, clockwise order: 126578, strands 7 and 8 are parallel to each other
    Derived from SCOP 50890
  • fold FAD-binding/transporter-associated domain-like (2000573)
    consists of two alpha+beta subdomains
    Derived from SCOP 56175
  • fold Anti-LPS factor/recA domain (2000610)
    alpha-beta(3)-alpha(2), 2 layers, alpha/beta
    Derived from SCOP 54751
  • fold RbfA-like (2000652)
    formerly: Alpha-lytic protease prodomain-like; alpha-beta(2)-(alpha)-beta, 2 layers: alpha/beta, mixed beta-sheet, order 123, strand 1 is antiparallel to the rest
    Derived from SCOP 54805
  • fold Obg protein C-terminal domain-like (2000732)
    beta-(2)-alpha(3)-beta(2), 2 layers: beta/alpha, mixed beta-sheet: order 1234, strands 2 and 3 a parallel to each other
    Derived from SCOP 102740
  • fold CobW C-terminal domain-like (2000788)
    beta-alpha-beta(4)-alpha, 2 layers: a/b, antiparallel sheet 15234, topological similarity to the HPr-like fold
    Derived from SCOP 90001
  • fold MutS N-terminal domain-like (2001031)
    beta(2)-alpha-beta(2)-alpha-beta(2), 2 layers, alpha/beta
    Derived from SCOP 55266
  • fold MalF P2 linker domain-like (2001253)
    alpha-beta(5); 2 layers; meander 5-stranded beta-sheet is folded into a half-barrel
    Derived from SCOP 160963
  • fold UvrA UvrB-binding domain-like (2001256)
    alpha-beta-alpha-beta(2)-X-beta-alpha-beta(2); two layers: a/b; antiparallel beta sheet of six strands, order: 651423; internal pseudo twofold symmetry
  • fold P-loop kinase-like (2001257)
    3 layers: a/b/a; parallel beta sheet of five strands, order: 23145