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fold 6PGDH C-terminal helical region-like (2000006)
not a true fold: inherited from old scop, it varies greatly between the members; to be obsoleted in future
Derived from SCOP 48178

Protein Type

Globular proteinsFold into compact units. Soluble in aqueous solutions

Children

  • superfamily 6-phosphogluconate dehydrogenase-like (3000048)
    Superfamily region spans from the first common strands to the last common helix, 8-stranded beta-sheet, order:32145678, strands 7 and 8 are parallel to each other and antiparallel to the rest
    Derived from SCOP 51735
Domains PDB ID RegionMethodResolution
Representative CF domain (8001105)
3-hydroxyisobutyrate dehydrogenase
complexed with ndp

Thermus thermophilus HB8 (300852)

 Q5SLQ6 158-289

Derived from SCOP domain 130890
rasmol icon 2CVZ A:158-289 X-RAY DIFFRACTION 1.80
Clustered domains rasmol icon 1WP4 A:158-289 X-RAY DIFFRACTION 2.00
rasmol icon 1WP4 B:158-289 X-RAY DIFFRACTION 2.00
rasmol icon 1WP4 C:158-289 X-RAY DIFFRACTION 2.00
rasmol icon 1WP4 D:158-289 X-RAY DIFFRACTION 2.00
rasmol icon 2CVZ B:158-289 X-RAY DIFFRACTION 1.80
rasmol icon 2CVZ C:158-289 X-RAY DIFFRACTION 1.80
rasmol icon 2CVZ D:158-289 X-RAY DIFFRACTION 1.80
Representative CF domain (8001126)
Ketol-acid reductoisomerase (EC 11.1.86) (Acetohydroxy-acid isomeroreductase) (Alpha-keto-beta-hydroxylacil reductoisomerase)

Pseudomonas aeruginosa (287)

 Q9HVA2 183-327

Derived from SCOP domain 85946
rasmol icon 1NP3 A:183-327 X-RAY DIFFRACTION 2.00
Clustered domains rasmol icon 1NP3 B:183-327 X-RAY DIFFRACTION 2.00
rasmol icon 1NP3 C:183-327 X-RAY DIFFRACTION 2.00
rasmol icon 1NP3 D:183-327 X-RAY DIFFRACTION 2.00
Representative CF domain (8001138)
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial precursor (EC 11.1.35) (Short chain 3-hydroxyacyl-CoA dehydrogenase) (HCDH) (Medium and short chain L-3-hydroxyacyl-coenzyme A dehydrogenase)

Homo sapiens (9606)

 Q16836 216-314

Derived from SCOP domain 18793
rasmol icon 1F0Y A:204-302 X-RAY DIFFRACTION 1.80
Clustered domains rasmol icon 1F0Y B:204-302 X-RAY DIFFRACTION 1.80
rasmol icon 1F12 A:204-302 X-RAY DIFFRACTION 2.40
rasmol icon 1F12 B:204-302 X-RAY DIFFRACTION 2.40
rasmol icon 1F14 A:204-302 X-RAY DIFFRACTION 2.30
rasmol icon 1F14 B:204-302 X-RAY DIFFRACTION 2.30
rasmol icon 1F17 A:204-302 X-RAY DIFFRACTION 2.30
rasmol icon 1F17 B:204-302 X-RAY DIFFRACTION 2.30
rasmol icon 1IL0 A:204-302 X-RAY DIFFRACTION 2.20
rasmol icon 1IL0 B:204-302 X-RAY DIFFRACTION 2.20
rasmol icon 1LSJ A:204-302 X-RAY DIFFRACTION 2.50
rasmol icon 1LSJ B:204-302 X-RAY DIFFRACTION 2.50
rasmol icon 1LSO A:204-302 X-RAY DIFFRACTION 2.60
rasmol icon 1LSO B:204-302 X-RAY DIFFRACTION 2.60
rasmol icon 1M75 A:204-302 X-RAY DIFFRACTION 2.30
rasmol icon 1M75 B:204-302 X-RAY DIFFRACTION 2.30
rasmol icon 1M76 A:204-302 X-RAY DIFFRACTION 2.15
rasmol icon 1M76 B:204-302 X-RAY DIFFRACTION 2.15
rasmol icon 2HDH A:204-302 X-RAY DIFFRACTION 2.20
rasmol icon 2HDH B:204-302 X-RAY DIFFRACTION 2.20
rasmol icon 3HAD A:204-302 X-RAY DIFFRACTION 2.0
rasmol icon 3HAD B:204-302 X-RAY DIFFRACTION 2.0
rasmol icon 3RQS A:216-314 X-RAY DIFFRACTION 2.001
rasmol icon 3RQS B:216-314 X-RAY DIFFRACTION 2.001
Representative CF domain (8001151)
Conserved protein

Methanothermobacter thermautotrophicus (145262)

 O27779 153-264

Derived from SCOP domain 71108
rasmol icon 1I36 A:153-264 X-RAY DIFFRACTION 2.00
Clustered domains rasmol icon 1I36 B:153-264 Some residues were not observed X-RAY DIFFRACTION 2.00
Representative CF domain (8001157)
UDP-glucose 6-dehydrogenase (EC 11.1.22) (UDP-Glc dehydrogenase) (UDP-GlcDH) (UDPGDH)
complexed with gol, nad, so4, udx

Streptococcus pyogenes (1314)

 P0C0F4 197-294

Derived from SCOP domain 18809
rasmol icon 1DLI A:197-294 X-RAY DIFFRACTION 2.31
Clustered domains rasmol icon 1DLJ A:197-294 X-RAY DIFFRACTION 1.80
Representative CF domain (8001166)
Opine dehydrogenase (EC 15.1.28) (N-(1-D-carboxyethyl)-L-norvaline dehydrogenase)

Arthrobacter sp. 1C (79670)

 Q44297 188-359

Derived from SCOP domain 18810
rasmol icon 1BG6 A:188-359 X-RAY DIFFRACTION 1.8
Representative CF domain (8001172)
Glycerol-3-phosphate dehydrogenase [NAD(P)+] (EC 11.1.94) (NAD(P)H- dependent glycerol-3-phosphate dehydrogenase)

Archaeoglobus fulgidus (2234)

 O29390 181-335

Derived from SCOP domain 112775
rasmol icon 1TXG A:181-335 X-RAY DIFFRACTION 1.70
Clustered domains rasmol icon 1TXG B:181-335 X-RAY DIFFRACTION 1.70
Representative CF domain (8001179)
2-dehydropantoate 2-reductase (EC 11.1.169) (Ketopantoate reductase) (KPA reductase) (KPR)

Escherichia coli (562)

 P0A9J4 168-291

Derived from SCOP domain 68857
rasmol icon 1KS9 A:168-291 X-RAY DIFFRACTION 1.70
Clustered domains rasmol icon 1YJQ A:168-291 X-RAY DIFFRACTION 2.09
rasmol icon 1YON A:168-291 X-RAY DIFFRACTION 1.95

Escherichia coli K-12 (83333)

rasmol icon 2OFP A:168-291 X-RAY DIFFRACTION 2.30

Escherichia coli K-12 (83333)

rasmol icon 2OFP B:168-291 X-RAY DIFFRACTION 2.30
Representative CF domain (8001185)
Pyrroline-5-carboxylate reductase (EC 15.1.2).
complexed with so4

Neisseria meningitidis MC58 (122586)

 Q9K1N1 153-263

Derived from SCOP domain 145920
rasmol icon 1YQG A:153-263 X-RAY DIFFRACTION 1.90
Clustered domains rasmol icon 2AG8 A:153-263 X-RAY DIFFRACTION 2.10
Representative CF domain (8001192)
5,10-methenyltetrahydromethanopterin hydrogenase (EC 112.98.2) (H(2)- forming N(5),N(10)-methylenetetrahydromethanopterin dehydrogenase) (N(5),N(10)-methenyltetrahydromethanopterin hydrogenase) (H(2)- dependent methylene-H(4)MPT dehydrogenase)

Methanocaldococcus jannaschii (2190)

 Q58194 243-344

Derived from SCOP domain 127639
rasmol icon 2B0J A:243-344 X-RAY DIFFRACTION 1.75
Clustered domains rasmol icon 3DAF A:243-344 X-RAY DIFFRACTION 1.75
rasmol icon 3DAG A:243-344 X-RAY DIFFRACTION 1.75
rasmol icon 3F46 A:243-344 X-RAY DIFFRACTION 1.950
rasmol icon 3F47 A:243-344 X-RAY DIFFRACTION 1.750
rasmol icon 3H65 A:243-344 X-RAY DIFFRACTION 2.150
Representative CF domain (8001198)
Prephenate dehydrogenase
complexed with nad

Aquifex aeolicus VF5 (224324)

 O67636 201-310

Derived from SCOP domain 134648
rasmol icon 2G5C B:201-310 X-RAY DIFFRACTION 1.90
Clustered domains rasmol icon 2G5C A:201-310 Some residues were not observed X-RAY DIFFRACTION 1.90
rasmol icon 2G5C C:201-308 The ends of this domain were trimmed X-RAY DIFFRACTION 1.90
rasmol icon 2G5C D:201-308 The ends of this domain were trimmed X-RAY DIFFRACTION 1.90

Aquifex aeolicus (63363)

rasmol icon 3GGG A:201-310 X-RAY DIFFRACTION 2.21

Aquifex aeolicus (63363)

rasmol icon 3GGG B:201-307 The ends of this domain were trimmed X-RAY DIFFRACTION 2.21

Aquifex aeolicus (63363)

rasmol icon 3GGG C:201-305 The ends of this domain were trimmed X-RAY DIFFRACTION 2.21

Aquifex aeolicus (63363)

rasmol icon 3GGG D:201-310 X-RAY DIFFRACTION 2.21

Aquifex aeolicus (63363)

rasmol icon 3GGO A:201-310 X-RAY DIFFRACTION 2.15

Aquifex aeolicus (63363)

rasmol icon 3GGO B:201-309 The ends of this domain were trimmed X-RAY DIFFRACTION 2.15

Aquifex aeolicus (63363)

rasmol icon 3GGO C:201-305 The ends of this domain were trimmed X-RAY DIFFRACTION 2.15

Aquifex aeolicus (63363)

rasmol icon 3GGO D:201-308 The ends of this domain were trimmed X-RAY DIFFRACTION 2.15

Aquifex aeolicus (63363)

rasmol icon 3GGP A:201-310 X-RAY DIFFRACTION 2.25

Aquifex aeolicus (63363)

rasmol icon 3GGP B:201-309 The ends of this domain were trimmed X-RAY DIFFRACTION 2.25

Aquifex aeolicus (63363)

rasmol icon 3GGP C:201-310 X-RAY DIFFRACTION 2.25

Aquifex aeolicus (63363)

rasmol icon 3GGP D:201-310 X-RAY DIFFRACTION 2.25
Representative CF domain (8001206)
Putative uncharacterized protein
complexed with ndp

Thermotoga maritima (2336)

 Q9X250 155-257

Derived from SCOP domain 147535
rasmol icon 2I76 A:155-257 X-RAY DIFFRACTION 3.00
Clustered domains rasmol icon 2I76 B:155-254 The ends of this domain were trimmed X-RAY DIFFRACTION 3.00
Representative CF domain (8001232)
Mannitol dehydrogenase (EC 11.1.67).
complexed with mse, nad

Pseudomonas fluorescens (294)

 O08355 287-492

Derived from SCOP domain 90392
rasmol icon 1LJ8 A:287-492 X-RAY DIFFRACTION 1.70
Clustered domains rasmol icon 1M2W A:287-492 X-RAY DIFFRACTION 1.80
rasmol icon 1M2W B:287-492 X-RAY DIFFRACTION 1.80
Representative CF domain (8017510)
Fatty acid oxidation complex subunit alpha [Includes: Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase/3- hydroxybutyryl-CoA epimerase (EC 42.1.17) (EC 5.3.3.8) (EC 5.1.2.3); 3-hydroxyacyl-CoA dehydrogenase (EC 11.1.35)].

Pseudomonas fragi (296)

 P28793 497-715

Derived from SCOP domain 109250
rasmol icon 1WDK A:497-715 X-RAY DIFFRACTION 2.5
Clustered domains rasmol icon 1WDK B:497-715 X-RAY DIFFRACTION 2.5
rasmol icon 1WDL A:497-715 X-RAY DIFFRACTION 3.5
rasmol icon 1WDL B:497-715 X-RAY DIFFRACTION 3.5
rasmol icon 1WDM A:497-715 X-RAY DIFFRACTION 3.8
rasmol icon 1WDM B:497-715 X-RAY DIFFRACTION 3.8
rasmol icon 2D3T A:497-715 X-RAY DIFFRACTION 3.4
rasmol icon 2D3T B:497-715 X-RAY DIFFRACTION 3.4
Representative CF domain (8017576)
6-phosphogluconate dehydrogenase, decarboxylating (EC 11.1.44).
complexed with so4

Ovis aries (9940)

 P00349 178-474

Derived from SCOP domain 18778
rasmol icon 2PGD A:177-473 X-RAY DIFFRACTION 2.
Clustered domains rasmol icon 1PGN A:177-473 X-RAY DIFFRACTION 2.3
rasmol icon 1PGO A:177-473 X-RAY DIFFRACTION 2.5
rasmol icon 1PGP A:177-473 X-RAY DIFFRACTION 2.5
rasmol icon 1PGQ A:177-473 X-RAY DIFFRACTION 3.17
Representative CF domain (8017595)
Ketol-acid reductoisomerase, chloroplast precursor (EC 11.1.86) (Acetohydroxy-acid reductoisomerase) (Alpha-keto-beta-hydroxylacil reductoisomerase)

Spinacia oleracea (3562)

 Q01292 308-595

Derived from SCOP domain 18785
rasmol icon 1QMG A:308-595 X-RAY DIFFRACTION 1.6
Clustered domains rasmol icon 1QMG B:308-595 X-RAY DIFFRACTION 1.6
rasmol icon 1QMG C:308-595 X-RAY DIFFRACTION 1.6
rasmol icon 1QMG D:308-595 X-RAY DIFFRACTION 1.6
rasmol icon 1YVE I:308-595 X-RAY DIFFRACTION 1.65
rasmol icon 1YVE J:308-595 X-RAY DIFFRACTION 1.65
rasmol icon 1YVE K:308-595 X-RAY DIFFRACTION 1.65
rasmol icon 1YVE L:308-595 X-RAY DIFFRACTION 1.65