Parents

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Fold

fold Rossmann(2x2)oid (2000009)
3 layers: a/b/a, parallel beta-sheet of 4 strands, 2134
Derived from SCOP 53222

Protein Type

Globular proteinsFold into compact units. Soluble in aqueous solutions

Children

  • protein GTPase HflX (5009649)
  • family LpxK-like (4003999)
    Pfam: PF02606
  • family HydF C-terminal region (4004040)
    No Pfam; comprises two structurally similar Rossmann(2x2)oid domains related by a pseudo twofold symmetry
  • superfamily BRCT domain-like (3000159)
    Derived from SCOP 52113
  • superfamily Initiation factor IF2/eIF5b domain 3-like (3001128)
    Placeholder SF, inherited from SCOP
    Derived from SCOP 52156
  • superfamily MtdA-like (3000046)
    2 domains; the superfamily region is trimmed from the first to the last common structural elements; the coenzyme-binding domain resides in the C-terminal part, its beta-sheet topology varies slightly between the families; the N-terminal domain contains mostly parallel beta-sheet and also shows topological variations
    Derived from SCOP 51735
Domains PDB ID RegionMethodResolution
Representative CF domain (8001048)
Bifunctional protein mdtA [Includes: NADP-dependent methylenetetrahydromethanopterin dehydrogenase (EC 15.1.-); Methylenetetrahydrofolate dehydrogenase (EC 15.1.5)].

Methylobacterium extorquens AM1 (272630)

 P55818 2-97

Derived from SCOP domain 78217
rasmol icon 1LUA A:2-97 X-RAY DIFFRACTION 1.90
Clustered domains rasmol icon 1LU9 A:2-97 X-RAY DIFFRACTION 1.90
rasmol icon 1LU9 B:2-97 X-RAY DIFFRACTION 1.90
rasmol icon 1LU9 C:2-97 X-RAY DIFFRACTION 1.90
rasmol icon 1LUA B:2-97 X-RAY DIFFRACTION 1.90
rasmol icon 1LUA C:2-97 X-RAY DIFFRACTION 1.90
Representative CF domain (8001074)
Malate oxidoreductase

Thermotoga maritima MSB8 (243274)

 Q9WZ12 58-154

Derived from SCOP domain 108725
rasmol icon 1VL6 A:58-154 X-RAY DIFFRACTION 2.61
Clustered domains rasmol icon 1VL6 B:58-154 X-RAY DIFFRACTION 2.61
rasmol icon 1VL6 C:58-154 X-RAY DIFFRACTION 2.61
rasmol icon 1VL6 D:58-154 X-RAY DIFFRACTION 2.61

Thermotoga maritima (2336)

rasmol icon 2HAE A:58-154 X-RAY DIFFRACTION 3.13

Thermotoga maritima (2336)

rasmol icon 2HAE B:58-154 X-RAY DIFFRACTION 3.13

Thermotoga maritima (2336)

rasmol icon 2HAE C:58-154 X-RAY DIFFRACTION 3.13

Thermotoga maritima (2336)

rasmol icon 2HAE D:58-154 X-RAY DIFFRACTION 3.13
Representative CF domain (8004133)
BRCA1-associated RING domain protein 1

Homo sapiens (9606)

 Q99728 568-644

rasmol icon 2NTE A:568-644 X-RAY DIFFRACTION 1.90
Clustered domains rasmol icon 2NTE B:569-644 The ends of this domain were trimmed X-RAY DIFFRACTION 1.90
rasmol icon 2R1Z A:569-644 The ends of this domain were trimmed X-RAY DIFFRACTION 2.100
rasmol icon 2R1Z B:569-644 The ends of this domain were trimmed X-RAY DIFFRACTION 2.100
rasmol icon 3FA2 A:568-644 X-RAY DIFFRACTION 2.20
rasmol icon 3FA2 B:568-644 X-RAY DIFFRACTION 2.20
Representative CF domain (8018021)
Tetraacyldisaccharide 4-kinase

Aquifex aeolicus VF5 (224324)

 O67572 227-295

rasmol icon 4EHY A:227-295 X-RAY DIFFRACTION 2.1990
Clustered domains rasmol icon 4EHW A:227-295 X-RAY DIFFRACTION 2.3000
rasmol icon 4EHX A:227-295 X-RAY DIFFRACTION 1.9000
rasmol icon 4ITL A:227-295 X-RAY DIFFRACTION 2.0900
rasmol icon 4ITM A:227-295 X-RAY DIFFRACTION 2.1994
rasmol icon 4ITN A:227-295 X-RAY DIFFRACTION 2.1912
rasmol icon 4LKV A:227-295 X-RAY DIFFRACTION 3.5109
rasmol icon 4LKV B:227-295 X-RAY DIFFRACTION 3.5109
rasmol icon 4LKV C:227-295 X-RAY DIFFRACTION 3.5109
rasmol icon 4LKV D:227-295 X-RAY DIFFRACTION 3.5109
Representative CF domain (8019315)
Small GTP-binding protein

Thermotoga neapolitana DSM 4359 (309803)

 B9KBK7 221-301

rasmol icon 3QQ5 A:186-266 X-RAY DIFFRACTION 2.99
Representative CF domain (8019316)
Small GTP-binding protein

Thermotoga neapolitana DSM 4359 (309803)

 B9KBK7 328-414

rasmol icon 3QQ5 A:293-379 X-RAY DIFFRACTION 2.99
Representative CF domain (8019378)
GTPase HflX

Sulfolobus solfataricus (2287)

 Q980M3 1-86

rasmol icon 3KXI A:1-86 X-RAY DIFFRACTION 2.650
Clustered domains

Sulfolobus solfataricus P2 (273057)

rasmol icon 2QTF A:1-86 X-RAY DIFFRACTION 2.000

Sulfolobus solfataricus P2 (273057)

rasmol icon 2QTH A:1-86 X-RAY DIFFRACTION 2.00
rasmol icon 3KXK A:1-86 Some residues were not observed X-RAY DIFFRACTION 2.350
rasmol icon 3KXK B:2-86 The ends of this domain were trimmed X-RAY DIFFRACTION 2.350
rasmol icon 3KXL A:1-86 X-RAY DIFFRACTION 2.500
rasmol icon 3KXL B:2-86 The ends of this domain were trimmed X-RAY DIFFRACTION 2.500
Representative CF domain (8019797)
Probable translation initiation factor IF-2
complexed with gdp

Methanothermobacter thermautotrophicus (145262)

 O26359 351-461

Derived from SCOP domain 31032
rasmol icon 1G7S A:351-461 X-RAY DIFFRACTION 2
Clustered domains rasmol icon 1G7R A:351-461 X-RAY DIFFRACTION 2.2
rasmol icon 1G7T A:351-461 X-RAY DIFFRACTION 2

Saccharomyces cerevisiae,Methanothermobacter thermautotrophicus (4932,145262)

rasmol icon 4V8Z CV:351-461 ELECTRON MICROSCOPY 6.60