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Fold

fold FAD/NAD(P)-binding domain, circularly permuted variant 1 (2000034)
core: 3 layers, b/b/a, central parallel beta-sheet of 5 strands, order 15234, top antiparallel beta-sheet of 3 strands, meander
Derived from SCOP 51904

Protein Type

Globular proteinsFold into compact units. Soluble in aqueous solutions

Children

  • superfamily Thioredoxin reductase-like (3000050)
    duplication of the core domain; the resulting domains are segment-swapped after strands 4; the N-terminal domain binds FAD, whereas, in some members, the C-terminal domain binds NAD
    Derived from SCOP 51905
Domains PDB ID RegionMethodResolution
Representative CF domain (8001294)
Thioredoxin reductase (EC 18.1.9) (TRXR).

Escherichia coli (562)

 P0A9P4 120-245

Derived from SCOP domain 30532
rasmol icon 1TDE A:119-244 X-RAY DIFFRACTION 2.1
Clustered domains rasmol icon 1CL0 A:119-244 X-RAY DIFFRACTION 2.50
rasmol icon 1F6M A:119-244 X-RAY DIFFRACTION 2.95
rasmol icon 1F6M B:119-244 X-RAY DIFFRACTION 2.95
rasmol icon 1F6M E:119-244 X-RAY DIFFRACTION 2.95
rasmol icon 1F6M F:119-244 X-RAY DIFFRACTION 2.95
rasmol icon 1TDF A:119-244 X-RAY DIFFRACTION 2.3
rasmol icon 1TRB A:119-244 X-RAY DIFFRACTION 2.0
Representative CF domain (8001322)
Glutathione reductase, mitochondrial precursor (EC 18.1.7) (GR) (GRase)

Homo sapiens (9606)

 P00390 210-334

Derived from SCOP domain 30441
rasmol icon 3GRS A:166-290 X-RAY DIFFRACTION 1.54
Clustered domains rasmol icon 1BWC A:166-290 X-RAY DIFFRACTION 2.10
rasmol icon 1DNC A:166-290 X-RAY DIFFRACTION 1.7
rasmol icon 1GRA A:166-290 X-RAY DIFFRACTION 2.0
rasmol icon 1GRB A:166-290 X-RAY DIFFRACTION 1.85
rasmol icon 1GRE A:166-290 X-RAY DIFFRACTION 2.0
rasmol icon 1GRF A:166-290 X-RAY DIFFRACTION 2.0
rasmol icon 1GRG A:166-290 X-RAY DIFFRACTION 2.0
rasmol icon 1GRH A:166-290 X-RAY DIFFRACTION 3.00
rasmol icon 1GRT A:166-290 X-RAY DIFFRACTION 2.30
rasmol icon 1GSN A:166-290 X-RAY DIFFRACTION 1.7
rasmol icon 1K4Q A:166-290 X-RAY DIFFRACTION 1.9
rasmol icon 1XAN A:166-290 X-RAY DIFFRACTION 2.0
rasmol icon 2AAQ A:166-290 X-RAY DIFFRACTION 2.60
rasmol icon 2GH5 A:166-290 X-RAY DIFFRACTION 1.70
rasmol icon 2GH5 B:166-290 X-RAY DIFFRACTION 1.70
rasmol icon 2GRT A:166-290 X-RAY DIFFRACTION 2.70
rasmol icon 3DJG X:166-290 X-RAY DIFFRACTION 1.80
rasmol icon 3DJJ A:166-290 X-RAY DIFFRACTION 1.10
rasmol icon 3DK4 A:166-290 X-RAY DIFFRACTION 1.20
rasmol icon 3DK8 A:166-290 X-RAY DIFFRACTION 1.10
rasmol icon 3DK9 A:166-290 X-RAY DIFFRACTION 0.95
rasmol icon 3GRT A:166-290 X-RAY DIFFRACTION 2.50
rasmol icon 3SQP A:166-290 X-RAY DIFFRACTION 2.21
rasmol icon 3SQP B:166-290 X-RAY DIFFRACTION 2.21
rasmol icon 4GR1 A:166-290 X-RAY DIFFRACTION 2.4
rasmol icon 4GRT A:166-290 X-RAY DIFFRACTION 2.80
rasmol icon 5GRT A:166-290 X-RAY DIFFRACTION 2.40
Representative CF domain (8001455)
NADPH:adrenodoxin oxidoreductase, mitochondrial precursor (EC 118.1.2) (Adrenodoxin reductase) (AR) (Ferredoxin reductase) (Ferredoxin--NADP(+) reductase)
complexed with fad

Bos taurus (9913)

 P08165 139-363

Derived from SCOP domain 30319
rasmol icon 1CJC A:107-331 X-RAY DIFFRACTION 1.7
Clustered domains rasmol icon 1E1K A:107-331 X-RAY DIFFRACTION 1.95
rasmol icon 1E1L A:107-331 X-RAY DIFFRACTION 2.3
rasmol icon 1E1M A:107-331 X-RAY DIFFRACTION 1.85
rasmol icon 1E1N A:107-331 X-RAY DIFFRACTION 2.4
rasmol icon 1E6E A:107-331 X-RAY DIFFRACTION 2.3
rasmol icon 1E6E C:107-331 X-RAY DIFFRACTION 2.3
Representative CF domain (8001485)
Sulfide dehydrogenase [flavocytochrome c] flavoprotein chain precursor (EC 18.2.-) (FC) (FCSD) (Flavocytochrome c flavoprotein subunit).

Allochromatium vinosum (1049)

 Q06530 145-285

Derived from SCOP domain 30594
rasmol icon 1FCD A:115-255 X-RAY DIFFRACTION 2.53
Clustered domains rasmol icon 1FCD B:115-255 X-RAY DIFFRACTION 2.53
Representative CF domain (8017505)
Dihydropyrimidine dehydrogenase [NADP+] precursor (EC 13.1.2) (DPD) (DHPDHase) (Dihydrouracil dehydrogenase) (Dihydrothymine dehydrogenase)

Sus scrofa (9823)

 Q28943 288-440

Derived from SCOP domain 30324
rasmol icon 1H7W A:288-440 X-RAY DIFFRACTION 1.90
Clustered domains rasmol icon 1GT8 A:288-440 X-RAY DIFFRACTION 3.3
rasmol icon 1GT8 B:288-440 X-RAY DIFFRACTION 3.3
rasmol icon 1GT8 C:288-440 X-RAY DIFFRACTION 3.3
rasmol icon 1GT8 D:288-440 X-RAY DIFFRACTION 3.3
rasmol icon 1GTE A:288-440 X-RAY DIFFRACTION 1.65
rasmol icon 1GTE B:288-440 X-RAY DIFFRACTION 1.65
rasmol icon 1GTE C:288-440 X-RAY DIFFRACTION 1.65
rasmol icon 1GTE D:288-440 X-RAY DIFFRACTION 1.65
rasmol icon 1GTH A:288-440 X-RAY DIFFRACTION 2.25
rasmol icon 1GTH B:288-440 X-RAY DIFFRACTION 2.25
rasmol icon 1GTH C:288-440 X-RAY DIFFRACTION 2.25
rasmol icon 1GTH D:288-440 X-RAY DIFFRACTION 2.25
rasmol icon 1H7W B:288-440 X-RAY DIFFRACTION 1.90
rasmol icon 1H7W C:288-440 X-RAY DIFFRACTION 1.90
rasmol icon 1H7W D:288-440 X-RAY DIFFRACTION 1.90
rasmol icon 1H7X A:288-440 X-RAY DIFFRACTION 2.01
rasmol icon 1H7X B:288-440 X-RAY DIFFRACTION 2.01
rasmol icon 1H7X C:288-440 X-RAY DIFFRACTION 2.01
rasmol icon 1H7X D:288-440 X-RAY DIFFRACTION 2.01
Representative CF domain (8017531)
Alkyl hydroperoxide reductase subunit F (EC 16.4.-) (Alkyl hydroperoxide reductase F52A protein)
complexed with cl, fad, so4

Salmonella enterica subsp. enterica serovar Typhimurium (90371)

 P19480 326-451

Derived from SCOP domain 30548
rasmol icon 1HYU A:326-451 X-RAY DIFFRACTION 2.00
Representative CF domain (8017581)
Trimethylamine dehydrogenase (EC 15.8.2) (TMADh).

Methylophilus methylotrophus W3A1 (2327)

 P16099 491-646

Derived from SCOP domain 30313
rasmol icon 1DJN A:490-645 X-RAY DIFFRACTION 2.2
Clustered domains rasmol icon 1DJN B:490-645 X-RAY DIFFRACTION 2.2
rasmol icon 1DJQ A:490-645 X-RAY DIFFRACTION 2.2
rasmol icon 1DJQ B:490-645 X-RAY DIFFRACTION 2.2

Methylophilus methylotrophus (17)

rasmol icon 1O94 A:490-645 X-RAY DIFFRACTION 2.00

Methylophilus methylotrophus (17)

rasmol icon 1O94 B:490-645 X-RAY DIFFRACTION 2.00

Methylophilus methylotrophus (17)

rasmol icon 1O95 A:490-645 X-RAY DIFFRACTION 3.70

Methylophilus methylotrophus (17)

rasmol icon 1O95 B:490-645 X-RAY DIFFRACTION 3.70
rasmol icon 2TMD A:490-645 X-RAY DIFFRACTION 2.4
rasmol icon 2TMD B:490-645 X-RAY DIFFRACTION 2.4
Representative CF domain (8017591)
2,4-dienoyl-CoA reductase [NADPH] (EC 13.1.34) (2,4-dienoyl coenzyme A reductase)
complexed with cl, fad, fmn, fs4, mde, nap

Escherichia coli (562)

 P42593 466-628

Derived from SCOP domain 95077
rasmol icon 1PS9 A:466-627 X-RAY DIFFRACTION 2.2