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fold Variant FwdE/GAPDH domain-like fold (2000150)
not a true fold: different evolutionary elaborations of canonical FwdE/GAPDH domain-like fold
Derived from SCOP 55346

Protein Type

Globular proteinsFold into compact units. Soluble in aqueous solutions

Children

  • family Glucose 6-phosphate dehydrogenase-like (4000091)
    Rossmann-like domain: canonical parallel beta-sheet, 6 strands, order:321456; alpha+beta domain: mixed sheet, 8 strands, order: 23415678, psi-loop connects strands 4 and 5
    Derived from SCOP 51800
  • family Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)-like (4000077)
    Rossmann-like domain: parallel beta-sheet, 6 main strands, order:321456, may contain additional strands at the 3-edge (in the sequence before strand 3); alpha+beta domain: mixed sheet, 5 main strands, order: 21354, psi-loop connects strands 2 and 3; may have short extra strands on either or both edges
    Derived from SCOP 51800
  • family Biliverdin reductase-like (4000092)
    Rossmann-like domain: parallel beta-sheet, 6 main strands, order:321456, antiparallel short extra strand at the 3-edge; alpha+beta domain: mixed sheet, 6 strands, order: 234156, psi-loop connects strands 4 and 5
    Derived from SCOP 51800
  • family Homoserine dehydrogenase-like (4000093)
    Rossmann-like domain: mixed beta-sheet, 6 strands, order:321456, strand 3 is antiparallel to the rest; alpha+beta domain: mixed sheet, 5 strands, order: 32145, psi-loop connects strands 3 and 4
    Derived from SCOP 51800
  • family Saccharopine reductase-like (4000094)
    Rossmann-like domain: canonical parallel beta-sheet, 6 strands, order:321456; alpha+beta domain: bifurcated mixed sheet, 6 main strands, order: 321456, extra all-alpha subdomain is inserted into the psi-loop between strands 3 and 4
    Derived from SCOP 51800
Domains PDB ID RegionMethodResolution
Representative CF domain (8000886)
Glyceraldehyde-3-phosphate dehydrogenase A (EC 12.1.12) (GAPDH-A).

Escherichia coli (562)

 P0A9B2 150-313

Derived from SCOP domain 39865
rasmol icon 1GAD O:149-312 X-RAY DIFFRACTION 1.8
Clustered domains rasmol icon 1DC3 A:149-312 X-RAY DIFFRACTION 2.5
rasmol icon 1DC3 B:149-312 X-RAY DIFFRACTION 2.5
rasmol icon 1DC4 A:149-312 X-RAY DIFFRACTION 2.5
rasmol icon 1DC4 B:149-312 X-RAY DIFFRACTION 2.5
rasmol icon 1DC5 A:149-312 X-RAY DIFFRACTION 2.0
rasmol icon 1DC5 B:149-312 X-RAY DIFFRACTION 2.0
rasmol icon 1DC6 A:149-312 X-RAY DIFFRACTION 2.0
rasmol icon 1DC6 B:149-312 X-RAY DIFFRACTION 2.0
rasmol icon 1GAD P:149-312 X-RAY DIFFRACTION 1.8
rasmol icon 1GAE O:149-312 X-RAY DIFFRACTION 2.17
rasmol icon 1GAE P:149-312 X-RAY DIFFRACTION 2.17
rasmol icon 1S7C A:150-313 X-RAY DIFFRACTION 2.04
rasmol icon 2VYN A:148-311 X-RAY DIFFRACTION 2.20
rasmol icon 2VYN B:148-311 X-RAY DIFFRACTION 2.20
rasmol icon 2VYN C:148-311 X-RAY DIFFRACTION 2.20
rasmol icon 2VYV A:148-311 X-RAY DIFFRACTION 2.38
rasmol icon 2VYV B:148-311 X-RAY DIFFRACTION 2.38
rasmol icon 2VYV C:148-311 X-RAY DIFFRACTION 2.38
Representative CF domain (8000925)
Glucose-6-phosphate 1-dehydrogenase (EC 11.1.49) (G6PD).
complexed with nap, so4, mutant

Leuconostoc mesenteroides (1245)

 P11411 183-376

Derived from SCOP domain 60817
rasmol icon 1H9A A:182-375 X-RAY DIFFRACTION 2.16
Clustered domains rasmol icon 1DPG A:182-375 X-RAY DIFFRACTION 2.0
rasmol icon 1DPG B:182-375 X-RAY DIFFRACTION 2.0
rasmol icon 1E77 A:182-375 X-RAY DIFFRACTION 2.69
rasmol icon 1E7M A:182-375 X-RAY DIFFRACTION 2.54
rasmol icon 1E7Y A:182-375 X-RAY DIFFRACTION 2.48
rasmol icon 1H93 A:182-375 X-RAY DIFFRACTION 2.2
rasmol icon 1H94 A:182-375 X-RAY DIFFRACTION 2.50
rasmol icon 1H9B A:182-375 X-RAY DIFFRACTION 2.4
rasmol icon 2DPG A:182-375 X-RAY DIFFRACTION 2.5
Representative CF domain (8000944)
Biliverdin reductase A precursor (EC 13.1.24) (Biliverdin-IX alpha- reductase) (BVR A)
complexed with po4

Rattus norvegicus (10116)

 P46844 129-246

Derived from SCOP domain 73824
rasmol icon 1LC0 A:129-246 X-RAY DIFFRACTION 1.20
Clustered domains rasmol icon 1GCU A:129-246 X-RAY DIFFRACTION 1.4
rasmol icon 1LC3 A:129-246 X-RAY DIFFRACTION 1.50
Representative CF domain (8000956)
Saccharopine dehydrogenase [NADP+, L-glutamate-forming] (EC 15.1.10) (Saccharopine reductase)
there is an insertion of alpha-helical subdomain, composed of two structural repeats

Magnaporthe grisea (148305)

 Q9P4R4 124-388

Derived from SCOP domain 39955
rasmol icon 1E5Q A:124-388 X-RAY DIFFRACTION 2.10
Clustered domains rasmol icon 1E5L A:124-388 X-RAY DIFFRACTION 2.40
rasmol icon 1E5L B:124-388 X-RAY DIFFRACTION 2.40
rasmol icon 1E5Q B:124-388 X-RAY DIFFRACTION 2.10
rasmol icon 1E5Q C:124-388 X-RAY DIFFRACTION 2.10
rasmol icon 1E5Q D:124-388 X-RAY DIFFRACTION 2.10
rasmol icon 1E5Q E:124-388 X-RAY DIFFRACTION 2.10
rasmol icon 1E5Q F:124-388 X-RAY DIFFRACTION 2.10
rasmol icon 1E5Q G:124-388 X-RAY DIFFRACTION 2.10
rasmol icon 1E5Q H:124-388 X-RAY DIFFRACTION 2.10
rasmol icon 1FF9 A:124-388 X-RAY DIFFRACTION 2.00
Representative CF domain (8004329)
Homoserine dehydrogenase (EC 11.1.3) (HDH).
there are two helical insertions in the common fold of the C-terminal domain

Saccharomyces cerevisiae (4932)

 P31116 151-340

Derived from SCOP domain 39948
rasmol icon 1EBF A:151-340 X-RAY DIFFRACTION 2.30
Clustered domains rasmol icon 1EBF B:151-340 X-RAY DIFFRACTION 2.30
rasmol icon 1EBU A:151-340 X-RAY DIFFRACTION 2.60
rasmol icon 1EBU B:151-340 X-RAY DIFFRACTION 2.60
rasmol icon 1EBU C:151-340 X-RAY DIFFRACTION 2.60
rasmol icon 1EBU D:151-340 X-RAY DIFFRACTION 2.60
rasmol icon 1Q7G A:151-340 X-RAY DIFFRACTION 2.60
rasmol icon 1Q7G B:151-340 X-RAY DIFFRACTION 2.60
rasmol icon 1TVE A:151-340 X-RAY DIFFRACTION 3.00
rasmol icon 1TVE B:151-340 X-RAY DIFFRACTION 3.00