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Fold

fold Variant Rossmann fold (2000151)
not a true fold: other evolutionary elaborations of a canonical Rossmann fold, which are not conserved in a superfamily
Derived from SCOP 56326

Protein Type

Globular proteinsFold into compact units. Soluble in aqueous solutions

Children

  • family Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)-like (4000077)
    Rossmann-like domain: parallel beta-sheet, 6 main strands, order:321456, may contain additional strands at the 3-edge (in the sequence before strand 3); alpha+beta domain: mixed sheet, 5 main strands, order: 21354, psi-loop connects strands 2 and 3; may have short extra strands on either or both edges
    Derived from SCOP 51800
  • family Homoserine dehydrogenase-like (4000093)
    Rossmann-like domain: mixed beta-sheet, 6 strands, order:321456, strand 3 is antiparallel to the rest; alpha+beta domain: mixed sheet, 5 strands, order: 32145, psi-loop connects strands 3 and 4
    Derived from SCOP 51800
  • family DXP reductoisomerase-like (4000096)
    Rossmann-like domain: parallel beta-sheet, 7 strands, order:4321567; alpha+beta domain: mixed sheet, 4 strands, order: 2134, psi-loop connects strands 2 and 3; extra C-terminal domain: 4-helical bundle, right-handed superhelix
    Derived from SCOP 51800
  • family Methylene-tetrahydromethanopterin dehydrogenase (MtdA)-like (4000100)
    domain 1: 4-stranded parallel beta-sheet, order: 2134; domain 2: 7-stranded beta-sheet, order: 3214576, strand 6 is antiparallel to the rest
    Derived from SCOP 51883
  • family FolD-like (4000102)
    domain 1: 3-stranded parallel beta-sheet, order: 213; domain 2: 5-stranded parallel beta-sheet, order: 21345
    Derived from SCOP 51883
  • family Malate oxidoreductase-like (4000103)
    domain 1: 4-stranded parallel beta-sheet, order: 2134; domain 2: 6-stranded beta-sheet, order: 3214576, strand 3 is antiparallel to the rest
    Derived from SCOP 51883
Domains PDB ID RegionMethodResolution
Representative CF domain (8004327)
Glyceraldehyde-3-phosphate dehydrogenase A (EC 12.1.12) (GAPDH-A).

Escherichia coli (562)

 P0A9B2 2-149

Derived from SCOP domain 29950
rasmol icon 1GAD O:0-148 X-RAY DIFFRACTION 1.8
Clustered domains rasmol icon 1DC3 A:0-148 X-RAY DIFFRACTION 2.5
rasmol icon 1DC3 B:0-148 X-RAY DIFFRACTION 2.5
rasmol icon 1DC4 A:0-148 X-RAY DIFFRACTION 2.5
rasmol icon 1DC4 B:0-148 X-RAY DIFFRACTION 2.5
rasmol icon 1DC5 A:0-148 X-RAY DIFFRACTION 2.0
rasmol icon 1DC5 B:0-148 X-RAY DIFFRACTION 2.0
rasmol icon 1DC6 A:0-148 X-RAY DIFFRACTION 2.0
rasmol icon 1DC6 B:0-148 X-RAY DIFFRACTION 2.0
rasmol icon 1GAD P:0-148 X-RAY DIFFRACTION 1.8
rasmol icon 1GAE O:0-148 X-RAY DIFFRACTION 2.17
rasmol icon 1GAE P:0-148 X-RAY DIFFRACTION 2.17
rasmol icon 1S7C A:2-149 X-RAY DIFFRACTION 2.04
rasmol icon 2VYN A:0-147 X-RAY DIFFRACTION 2.20
rasmol icon 2VYN B:0-147 X-RAY DIFFRACTION 2.20
rasmol icon 2VYN C:0-147 X-RAY DIFFRACTION 2.20
rasmol icon 2VYV A:0-147 X-RAY DIFFRACTION 2.38
rasmol icon 2VYV B:0-147 X-RAY DIFFRACTION 2.38
rasmol icon 2VYV C:0-147 X-RAY DIFFRACTION 2.38
Representative CF domain (8004330)
Homoserine dehydrogenase (EC 11.1.3) (HDH).

Saccharomyces cerevisiae (4932)

 P31116 2-146

Derived from SCOP domain 30033
rasmol icon 1EBF A:2-146 X-RAY DIFFRACTION 2.30
Clustered domains rasmol icon 1EBF B:2-146 X-RAY DIFFRACTION 2.30
rasmol icon 1EBU A:2-146 X-RAY DIFFRACTION 2.60
rasmol icon 1EBU B:2-146 X-RAY DIFFRACTION 2.60
rasmol icon 1EBU C:2-146 X-RAY DIFFRACTION 2.60
rasmol icon 1EBU D:2-146 X-RAY DIFFRACTION 2.60
rasmol icon 1Q7G A:2-146 X-RAY DIFFRACTION 2.60
rasmol icon 1Q7G B:2-146 X-RAY DIFFRACTION 2.60
rasmol icon 1TVE A:2-146 X-RAY DIFFRACTION 3.00
rasmol icon 1TVE B:2-146 X-RAY DIFFRACTION 3.00
Representative CF domain (8004332)
1-deoxy-D-xylulose 5-phosphate reductoisomerase (EC 11.1.267) (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomerase) (2-C- methyl-D-erythritol 4-phosphate synthase)

Escherichia coli (562)

 P45568 1-125

Derived from SCOP domain 104465
rasmol icon 1Q0Q A:1-125 X-RAY DIFFRACTION 1.9
Clustered domains rasmol icon 1JVS A:1-124 The ends of this domain were trimmed X-RAY DIFFRACTION 2.2
rasmol icon 1JVS B:1-124 The ends of this domain were trimmed X-RAY DIFFRACTION 2.2

Escherichia coli K-12 (83333)

rasmol icon 1K5H A:1-125 X-RAY DIFFRACTION 2.50

Escherichia coli K-12 (83333)

rasmol icon 1K5H B:1-125 X-RAY DIFFRACTION 2.50

Escherichia coli K-12 (83333)

rasmol icon 1K5H C:1-125 X-RAY DIFFRACTION 2.50
rasmol icon 1ONN A:1-125 X-RAY DIFFRACTION 2.6
rasmol icon 1ONN B:1-125 X-RAY DIFFRACTION 2.6
rasmol icon 1ONO A:1-125 X-RAY DIFFRACTION 2.50
rasmol icon 1ONO B:1-125 X-RAY DIFFRACTION 2.50
rasmol icon 1ONP A:1-125 X-RAY DIFFRACTION 2.5
rasmol icon 1ONP B:1-125 X-RAY DIFFRACTION 2.5
rasmol icon 1Q0H A:1-125 X-RAY DIFFRACTION 2.20
rasmol icon 1Q0L A:1-125 X-RAY DIFFRACTION 2.65
rasmol icon 1Q0Q B:1-125 X-RAY DIFFRACTION 1.9
rasmol icon 1T1R A:1-124 The ends of this domain were trimmed X-RAY DIFFRACTION 2.3
rasmol icon 1T1R B:1-124 The ends of this domain were trimmed X-RAY DIFFRACTION 2.3
rasmol icon 1T1S A:1-124 The ends of this domain were trimmed X-RAY DIFFRACTION 2.4
rasmol icon 1T1S B:1-124 The ends of this domain were trimmed X-RAY DIFFRACTION 2.4

Escherichia coli str. K-12 substr. W3110 (316407)

rasmol icon 2EGH A:1-124 The ends of this domain were trimmed X-RAY DIFFRACTION 2.20

Escherichia coli str. K-12 substr. W3110 (316407)

rasmol icon 2EGH B:1-124 The ends of this domain were trimmed X-RAY DIFFRACTION 2.20

Escherichia coli K-12 (83333)

rasmol icon 3ANL A:1-124 The ends of this domain were trimmed X-RAY DIFFRACTION 2.10

Escherichia coli K-12 (83333)

rasmol icon 3ANL B:1-124 The ends of this domain were trimmed X-RAY DIFFRACTION 2.10

Escherichia coli K-12 (83333)

rasmol icon 3ANM A:1-124 The ends of this domain were trimmed X-RAY DIFFRACTION 2.00

Escherichia coli K-12 (83333)

rasmol icon 3ANM B:1-124 The ends of this domain were trimmed X-RAY DIFFRACTION 2.00

Escherichia coli K-12 (83333)

rasmol icon 3ANN A:1-124 The ends of this domain were trimmed X-RAY DIFFRACTION 2.00

Escherichia coli K-12 (83333)

rasmol icon 3ANN B:1-124 The ends of this domain were trimmed X-RAY DIFFRACTION 2.00

Escherichia coli K-12 (83333)

rasmol icon 3R0I A:1-125 X-RAY DIFFRACTION 2.10

Escherichia coli K-12 (83333)

rasmol icon 3R0I B:1-125 X-RAY DIFFRACTION 2.10
Representative CF domain (8004340)
Bifunctional protein mdtA [Includes: NADP-dependent methylenetetrahydromethanopterin dehydrogenase (EC 15.1.-); Methylenetetrahydrofolate dehydrogenase (EC 15.1.5)].

Methylobacterium extorquens AM1 (272630)

 P55818 2-249

Derived from SCOP domain 78216
rasmol icon 1LUA A:2-249 X-RAY DIFFRACTION 1.90
Clustered domains rasmol icon 1LU9 A:2-249 X-RAY DIFFRACTION 1.90
rasmol icon 1LU9 B:2-249 X-RAY DIFFRACTION 1.90
rasmol icon 1LU9 C:2-249 X-RAY DIFFRACTION 1.90
rasmol icon 1LUA B:2-249 X-RAY DIFFRACTION 1.90
rasmol icon 1LUA C:2-249 X-RAY DIFFRACTION 1.90
Representative CF domain (8004342)
Bifunctional protein folD [Includes: Methylenetetrahydrofolate dehydrogenase (EC 15.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 35.4.9)].

Escherichia coli K-12 (83333)

 P24186 157-258

Derived from SCOP domain 30286
rasmol icon 1B0A A:157-258 X-RAY DIFFRACTION 2.56
Representative CF domain (8004344)
Malate oxidoreductase

Thermotoga maritima MSB8 (243274)

 Q9WZ12 180-304

Derived from SCOP domain 108724
rasmol icon 1VL6 A:180-304 X-RAY DIFFRACTION 2.61
Clustered domains rasmol icon 1VL6 B:180-304 X-RAY DIFFRACTION 2.61
rasmol icon 1VL6 C:180-304 X-RAY DIFFRACTION 2.61
rasmol icon 1VL6 D:180-304 X-RAY DIFFRACTION 2.61

Thermotoga maritima (2336)

rasmol icon 2HAE A:180-304 X-RAY DIFFRACTION 3.13

Thermotoga maritima (2336)

rasmol icon 2HAE B:180-304 X-RAY DIFFRACTION 3.13

Thermotoga maritima (2336)

rasmol icon 2HAE C:180-304 X-RAY DIFFRACTION 3.13

Thermotoga maritima (2336)

rasmol icon 2HAE D:180-304 Some residues were not observed X-RAY DIFFRACTION 3.13