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Fold

fold 6PGDH-type extended Rossmann fold (2000154)
3 layer alpha/beta/alpha, mixed beta-sheet of 8 strands, order 32145678, strands 7 and 8 are parallel to each other and antiparallel to the rest

Protein Type

Globular proteinsFold into compact units. Soluble in aqueous solutions

Children

  • superfamily 6-phosphogluconate dehydrogenase-like (3000048)
    Superfamily region spans from the first common strands to the last common helix, 8-stranded beta-sheet, order:32145678, strands 7 and 8 are parallel to each other and antiparallel to the rest
    Derived from SCOP 51735
Domains PDB ID RegionMethodResolution
Representative CF domain (8004345)
Putative uncharacterized protein

Archaeoglobus fulgidus (2234)

 O29370 1-181

Derived from SCOP domain 66478
rasmol icon 1JAY A:1-181 X-RAY DIFFRACTION 1.65
Clustered domains rasmol icon 1JAX A:1-181 X-RAY DIFFRACTION 1.80
rasmol icon 1JAX B:1-181 X-RAY DIFFRACTION 1.80
rasmol icon 1JAY B:1-181 X-RAY DIFFRACTION 1.65
Representative CF domain (8004346)
3-hydroxyisobutyrate dehydrogenase
complexed with ndp

Thermus thermophilus HB8 (300852)

 Q5SLQ6 2-157

Derived from SCOP domain 130891
rasmol icon 2CVZ A:2-157 X-RAY DIFFRACTION 1.80
Clustered domains rasmol icon 1WP4 A:2-157 X-RAY DIFFRACTION 2.00
rasmol icon 1WP4 B:2-157 X-RAY DIFFRACTION 2.00
rasmol icon 1WP4 C:2-157 X-RAY DIFFRACTION 2.00
rasmol icon 1WP4 D:2-157 X-RAY DIFFRACTION 2.00
rasmol icon 2CVZ B:2-157 X-RAY DIFFRACTION 1.80
rasmol icon 2CVZ C:2-157 X-RAY DIFFRACTION 1.80
rasmol icon 2CVZ D:2-157 X-RAY DIFFRACTION 1.80
Representative CF domain (8004347)
Mannitol dehydrogenase (EC 11.1.67).
complexed with mse, nad

Pseudomonas fluorescens (294)

 O08355 25-286

Derived from SCOP domain 90393
rasmol icon 1LJ8 A:25-286 X-RAY DIFFRACTION 1.70
Clustered domains rasmol icon 1M2W A:25-286 X-RAY DIFFRACTION 1.80
rasmol icon 1M2W B:25-286 X-RAY DIFFRACTION 1.80
Representative CF domain (8004348)
Ketol-acid reductoisomerase (EC 11.1.86) (Acetohydroxy-acid isomeroreductase) (Alpha-keto-beta-hydroxylacil reductoisomerase)

Pseudomonas aeruginosa (287)

 Q9HVA2 17-182

Derived from SCOP domain 85947
rasmol icon 1NP3 A:17-182 X-RAY DIFFRACTION 2.00
Clustered domains rasmol icon 1NP3 B:17-182 X-RAY DIFFRACTION 2.00
rasmol icon 1NP3 C:17-182 X-RAY DIFFRACTION 2.00
rasmol icon 1NP3 D:17-182 X-RAY DIFFRACTION 2.00
Representative CF domain (8004349)
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial precursor (EC 11.1.35) (Short chain 3-hydroxyacyl-CoA dehydrogenase) (HCDH) (Medium and short chain L-3-hydroxyacyl-coenzyme A dehydrogenase)

Homo sapiens (9606)

 Q16836 24-213

Derived from SCOP domain 30197
rasmol icon 1F0Y A:12-201 X-RAY DIFFRACTION 1.80
Clustered domains rasmol icon 1F0Y B:12-201 X-RAY DIFFRACTION 1.80
rasmol icon 1F12 A:12-201 X-RAY DIFFRACTION 2.40
rasmol icon 1F12 B:12-201 X-RAY DIFFRACTION 2.40
rasmol icon 1F14 A:12-201 X-RAY DIFFRACTION 2.30
rasmol icon 1F14 B:12-201 X-RAY DIFFRACTION 2.30
rasmol icon 1F17 A:12-201 X-RAY DIFFRACTION 2.30
rasmol icon 1F17 B:12-201 X-RAY DIFFRACTION 2.30
rasmol icon 1IL0 A:12-201 X-RAY DIFFRACTION 2.20
rasmol icon 1IL0 B:12-201 X-RAY DIFFRACTION 2.20
rasmol icon 1LSJ A:12-201 X-RAY DIFFRACTION 2.50
rasmol icon 1LSJ B:12-201 X-RAY DIFFRACTION 2.50
rasmol icon 1LSO A:12-201 X-RAY DIFFRACTION 2.60
rasmol icon 1LSO B:12-201 X-RAY DIFFRACTION 2.60
rasmol icon 1M75 A:12-201 X-RAY DIFFRACTION 2.30
rasmol icon 1M75 B:12-201 X-RAY DIFFRACTION 2.30
rasmol icon 1M76 A:12-201 X-RAY DIFFRACTION 2.15
rasmol icon 1M76 B:12-201 X-RAY DIFFRACTION 2.15
rasmol icon 2HDH A:12-201 X-RAY DIFFRACTION 2.20
rasmol icon 2HDH B:12-201 X-RAY DIFFRACTION 2.20
rasmol icon 3HAD A:12-201 X-RAY DIFFRACTION 2.0
rasmol icon 3HAD B:12-201 X-RAY DIFFRACTION 2.0
rasmol icon 3RQS A:24-213 X-RAY DIFFRACTION 2.001
rasmol icon 3RQS B:24-213 X-RAY DIFFRACTION 2.001
Representative CF domain (8004350)
Conserved protein

Methanothermobacter thermautotrophicus (145262)

 O27779 2-151

Derived from SCOP domain 71109
rasmol icon 1I36 A:2-151 X-RAY DIFFRACTION 2.00
Clustered domains rasmol icon 1I36 B:2-151 X-RAY DIFFRACTION 2.00
Representative CF domain (8004351)
UDP-glucose 6-dehydrogenase (EC 11.1.22) (UDP-Glc dehydrogenase) (UDP-GlcDH) (UDPGDH)
complexed with gol, nad, so4, udx

Streptococcus pyogenes (1314)

 P0C0F4 1-195

Derived from SCOP domain 30213
rasmol icon 1DLI A:1-195 X-RAY DIFFRACTION 2.31
Clustered domains rasmol icon 1DLJ A:1-195 X-RAY DIFFRACTION 1.80
Representative CF domain (8004352)
Opine dehydrogenase (EC 15.1.28) (N-(1-D-carboxyethyl)-L-norvaline dehydrogenase)

Arthrobacter sp. 1C (79670)

 Q44297 4-187

Derived from SCOP domain 30214
rasmol icon 1BG6 A:4-187 X-RAY DIFFRACTION 1.8
Representative CF domain (8004353)
Glycerol-3-phosphate dehydrogenase [NAD(P)+] (EC 11.1.94) (NAD(P)H- dependent glycerol-3-phosphate dehydrogenase)

Archaeoglobus fulgidus (2234)

 O29390 1-180

Derived from SCOP domain 112776
rasmol icon 1TXG A:1-180 X-RAY DIFFRACTION 1.70
Clustered domains rasmol icon 1TXG B:1-180 X-RAY DIFFRACTION 1.70
Representative CF domain (8004354)
2-dehydropantoate 2-reductase (EC 11.1.169) (Ketopantoate reductase) (KPA reductase) (KPR)

Escherichia coli (562)

 P0A9J4 1-167

Derived from SCOP domain 68858
rasmol icon 1KS9 A:1-167 X-RAY DIFFRACTION 1.70
Clustered domains rasmol icon 1YJQ A:1-167 X-RAY DIFFRACTION 2.09
rasmol icon 1YON A:1-167 X-RAY DIFFRACTION 1.95

Escherichia coli K-12 (83333)

rasmol icon 2OFP A:1-167 X-RAY DIFFRACTION 2.30

Escherichia coli K-12 (83333)

rasmol icon 2OFP B:1-167 X-RAY DIFFRACTION 2.30
Representative CF domain (8004355)
Pyrroline-5-carboxylate reductase (EC 15.1.2).
complexed with so4

Neisseria meningitidis MC58 (122586)

 Q9K1N1 1-152

Derived from SCOP domain 145921
rasmol icon 1YQG A:1-152 X-RAY DIFFRACTION 1.90
Clustered domains rasmol icon 2AG8 A:1-152 X-RAY DIFFRACTION 2.10
Representative CF domain (8004356)
5,10-methenyltetrahydromethanopterin hydrogenase (EC 112.98.2) (H(2)- forming N(5),N(10)-methylenetetrahydromethanopterin dehydrogenase) (N(5),N(10)-methenyltetrahydromethanopterin hydrogenase) (H(2)- dependent methylene-H(4)MPT dehydrogenase)

Methanocaldococcus jannaschii (2190)

 Q58194 1-242

Derived from SCOP domain 127640
rasmol icon 2B0J A:1-242 X-RAY DIFFRACTION 1.75
Clustered domains rasmol icon 3DAF A:1-242 X-RAY DIFFRACTION 1.75
rasmol icon 3DAG A:1-242 X-RAY DIFFRACTION 1.75
rasmol icon 3F46 A:1-242 X-RAY DIFFRACTION 1.950
rasmol icon 3F47 A:1-242 X-RAY DIFFRACTION 1.750
rasmol icon 3H65 A:1-242 X-RAY DIFFRACTION 2.150
Representative CF domain (8004357)
Prephenate dehydrogenase
complexed with nad

Aquifex aeolicus VF5 (224324)

 O67636 31-200

Derived from SCOP domain 134649
rasmol icon 2G5C B:31-200 X-RAY DIFFRACTION 1.90
Clustered domains rasmol icon 2G5C A:31-200 X-RAY DIFFRACTION 1.90
rasmol icon 2G5C C:31-200 X-RAY DIFFRACTION 1.90
rasmol icon 2G5C D:31-200 X-RAY DIFFRACTION 1.90

Aquifex aeolicus (63363)

rasmol icon 3GGG A:31-200 X-RAY DIFFRACTION 2.21

Aquifex aeolicus (63363)

rasmol icon 3GGG B:31-200 X-RAY DIFFRACTION 2.21

Aquifex aeolicus (63363)

rasmol icon 3GGG C:31-200 X-RAY DIFFRACTION 2.21

Aquifex aeolicus (63363)

rasmol icon 3GGG D:31-200 X-RAY DIFFRACTION 2.21

Aquifex aeolicus (63363)

rasmol icon 3GGO A:31-200 X-RAY DIFFRACTION 2.15

Aquifex aeolicus (63363)

rasmol icon 3GGO B:31-200 X-RAY DIFFRACTION 2.15

Aquifex aeolicus (63363)

rasmol icon 3GGO C:31-200 X-RAY DIFFRACTION 2.15

Aquifex aeolicus (63363)

rasmol icon 3GGO D:31-200 X-RAY DIFFRACTION 2.15

Aquifex aeolicus (63363)

rasmol icon 3GGP A:31-200 X-RAY DIFFRACTION 2.25

Aquifex aeolicus (63363)

rasmol icon 3GGP B:31-200 X-RAY DIFFRACTION 2.25

Aquifex aeolicus (63363)

rasmol icon 3GGP C:31-200 X-RAY DIFFRACTION 2.25

Aquifex aeolicus (63363)

rasmol icon 3GGP D:31-200 X-RAY DIFFRACTION 2.25
Representative CF domain (8004358)
Putative uncharacterized protein
complexed with ndp

Thermotoga maritima (2336)

 Q9X250 2-151

Derived from SCOP domain 147536
rasmol icon 2I76 A:2-151 X-RAY DIFFRACTION 3.00
Clustered domains rasmol icon 2I76 B:2-151 X-RAY DIFFRACTION 3.00
Representative CF domain (8017511)
Fatty acid oxidation complex subunit alpha [Includes: Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase/3- hydroxybutyryl-CoA epimerase (EC 42.1.17) (EC 5.3.3.8) (EC 5.1.2.3); 3-hydroxyacyl-CoA dehydrogenase (EC 11.1.35)].

Pseudomonas fragi (296)

 P28793 315-494

Derived from SCOP domain 109252
rasmol icon 1WDK A:315-494 X-RAY DIFFRACTION 2.5
Clustered domains rasmol icon 1WDK B:315-494 X-RAY DIFFRACTION 2.5
rasmol icon 1WDL A:315-494 X-RAY DIFFRACTION 3.5
rasmol icon 1WDL B:315-494 X-RAY DIFFRACTION 3.5
rasmol icon 1WDM A:315-494 X-RAY DIFFRACTION 3.8
rasmol icon 1WDM B:315-494 X-RAY DIFFRACTION 3.8
rasmol icon 2D3T A:315-494 X-RAY DIFFRACTION 3.4
rasmol icon 2D3T B:315-494 X-RAY DIFFRACTION 3.4
Representative CF domain (8017574)
6-phosphogluconate dehydrogenase, decarboxylating (EC 11.1.44).
complexed with so4

Ovis aries (9940)

 P00349 2-174

Derived from SCOP domain 30190
rasmol icon 2PGD A:1-173 X-RAY DIFFRACTION 2.
Clustered domains rasmol icon 1PGN A:1-173 X-RAY DIFFRACTION 2.3
rasmol icon 1PGO A:1-173 X-RAY DIFFRACTION 2.5
rasmol icon 1PGP A:1-173 X-RAY DIFFRACTION 2.5
rasmol icon 1PGQ A:1-173 X-RAY DIFFRACTION 3.17
Representative CF domain (8017593)
Ketol-acid reductoisomerase, chloroplast precursor (EC 11.1.86) (Acetohydroxy-acid reductoisomerase) (Alpha-keto-beta-hydroxylacil reductoisomerase)

Spinacia oleracea (3562)

 Q01292 106-306

Derived from SCOP domain 30182
rasmol icon 1QMG A:106-306 X-RAY DIFFRACTION 1.6
Clustered domains rasmol icon 1QMG B:106-306 X-RAY DIFFRACTION 1.6
rasmol icon 1QMG C:106-306 X-RAY DIFFRACTION 1.6
rasmol icon 1QMG D:106-306 X-RAY DIFFRACTION 1.6
rasmol icon 1YVE I:106-306 X-RAY DIFFRACTION 1.65
rasmol icon 1YVE J:106-306 X-RAY DIFFRACTION 1.65
rasmol icon 1YVE K:106-306 X-RAY DIFFRACTION 1.65
rasmol icon 1YVE L:106-306 X-RAY DIFFRACTION 1.65