Parents

  • hyperfamily Rossmann-like nucleotide-binding lobe (1100002)
    3 layer core: alpha/beta/alpha, parallel beta-sheet of 6 strands, order 321456; common region begins with strand 1 and ends with strand 6; the core is packed against the helix that, depending on a particular superfamily member, either precedes strands 1 (rare), or follows strand 6 (common)
    Derived from SCOP 51734
  • fold LDH C-terminal subdomain-like fold (2000008)
    alpha-beta(3)-alpha, meander beta-sheet twisted into a half-barrel, order 123, with helices packed at the opposite ends
    Derived from SCOP 56326
  • fold Canonical Rossmann fold (2000005)
    3 layers, alpha/beta/alpha, parallel beta-sheet of 6 strands, order 321456
    Derived from SCOP 51734
Go to Graph

Superfamily

superfamily LDH/MDH/AglA-like (3000039)
formerly two-domain, now the superfamily region is the entire protein; mixed beta-sheet, 9 strands, order:321456789; the first six strands comprise canonical parallel sheet, and the last three - antiparallel sheet, twisted into a half-barrel; member families differ by the numbers and sizes of additional structural elements
Derived from SCOP 51735

Children

  • family LDH/MDH-like (4000045)
    composed of proteins of significantly smaller sizes than the AlgA-like family members
    Derived from SCOP 51848
  • family AglA-like (4000089)
    composed of proteins of significantly greater sizes than the LDH/MDH-like family members
    Derived from SCOP 51848
Domains PDB ID RegionMethodResolution
Representative SF domain (8000769)
Malate dehydrogenase (EC 11.1.37).
merged with 139767

Escherichia coli K-12 (83333)

 P61889 1-312

Derived from SCOP domain 139766
rasmol icon 2PWZ A:1-312 X-RAY DIFFRACTION 2.200
Clustered domains

Escherichia coli (562)

rasmol icon 1EMD A:1-312 X-RAY DIFFRACTION 1.9

Escherichia coli (562)

rasmol icon 1IB6 A:1-312 X-RAY DIFFRACTION 2.10

Escherichia coli (562)

rasmol icon 1IB6 B:1-312 X-RAY DIFFRACTION 2.10

Escherichia coli (562)

rasmol icon 1IB6 C:1-312 X-RAY DIFFRACTION 2.10

Escherichia coli (562)

rasmol icon 1IB6 D:1-312 X-RAY DIFFRACTION 2.10

Escherichia coli (562)

rasmol icon 1IE3 A:1-312 X-RAY DIFFRACTION 2.50

Escherichia coli (562)

rasmol icon 1IE3 B:1-312 X-RAY DIFFRACTION 2.50

Escherichia coli (562)

rasmol icon 1IE3 C:1-312 X-RAY DIFFRACTION 2.50

Escherichia coli (562)

rasmol icon 1IE3 D:1-312 X-RAY DIFFRACTION 2.50

Escherichia coli (562)

rasmol icon 2CMD A:1-312 X-RAY DIFFRACTION 1.87
rasmol icon 2PWZ C:1-312 Some residues were not observed X-RAY DIFFRACTION 2.200
rasmol icon 2PWZ E:1-312 X-RAY DIFFRACTION 2.200
rasmol icon 2PWZ G:1-312 X-RAY DIFFRACTION 2.200
rasmol icon 3HHP A:1-312 X-RAY DIFFRACTION 1.450
rasmol icon 3HHP B:1-311 Some residues were not observed X-RAY DIFFRACTION 1.450
rasmol icon 3HHP C:1-312 X-RAY DIFFRACTION 1.450
rasmol icon 3HHP D:1-311 The ends of this domain were trimmed X-RAY DIFFRACTION 1.450
rasmol icon 5KKA A:1-311 Some residues were not observed X-RAY DIFFRACTION 1.75
rasmol icon 5KKA B:1-311 Some residues were not observed X-RAY DIFFRACTION 1.75
Representative SF domain (8001235)
Alpha-glucosidase (EC 32.1.20) (Maltase).
merged with 86761

Thermotoga maritima MSB8 (243274)

 O33830 2-480

Derived from SCOP domain 86760
rasmol icon 1OBB A:2-480 X-RAY DIFFRACTION 1.90
Clustered domains rasmol icon 1OBB B:4-480 The ends of this domain were trimmed X-RAY DIFFRACTION 1.90