Parents

  • hyperfamily Rossmann-like nucleotide-binding lobe (1100002)
    3 layer core: alpha/beta/alpha, parallel beta-sheet of 6 strands, order 321456; common region begins with strand 1 and ends with strand 6; the core is packed against the helix that, depending on a particular superfamily member, either precedes strands 1 (rare), or follows strand 6 (common)
    Derived from SCOP 51734
  • fold Canonical FwdE/GAPDH domain-like fold (2000032)
    alpha-beta-alpha-beta(3), 2 layers, alpha/beta sandwich, mixed sheet: 2134, strand 2 is parallel to strand 1, psi-loop between strands 2 and 3
    Derived from SCOP 55346
  • fold Canonical Rossmann fold (2000005)
    3 layers, alpha/beta/alpha, parallel beta-sheet of 6 strands, order 321456
    Derived from SCOP 51734
Go to Graph

Superfamily

superfamily GAPDH-like (3000043)
2-domain protein with an alpha+beta domain inserted after strand 6 of the Rossmann-like domain; in different families this additional domain varies in size and number of structural elements; its common core comprises a helix and 4-stranded mixed sheet with a characteristic psi-loop; the dihydrodipicolinate reductase-like family presents a minimal form of this domain
Derived from SCOP 51735

Children

  • family Glucose 6-phosphate dehydrogenase-like (4000091)
    Rossmann-like domain: canonical parallel beta-sheet, 6 strands, order:321456; alpha+beta domain: mixed sheet, 8 strands, order: 23415678, psi-loop connects strands 4 and 5
    Derived from SCOP 51800
  • family Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)-like (4000077)
    Rossmann-like domain: parallel beta-sheet, 6 main strands, order:321456, may contain additional strands at the 3-edge (in the sequence before strand 3); alpha+beta domain: mixed sheet, 5 main strands, order: 21354, psi-loop connects strands 2 and 3; may have short extra strands on either or both edges
    Derived from SCOP 51800
  • family Biliverdin reductase-like (4000092)
    Rossmann-like domain: parallel beta-sheet, 6 main strands, order:321456, antiparallel short extra strand at the 3-edge; alpha+beta domain: mixed sheet, 6 strands, order: 234156, psi-loop connects strands 4 and 5
    Derived from SCOP 51800
  • family Homoserine dehydrogenase-like (4000093)
    Rossmann-like domain: mixed beta-sheet, 6 strands, order:321456, strand 3 is antiparallel to the rest; alpha+beta domain: mixed sheet, 5 strands, order: 32145, psi-loop connects strands 3 and 4
    Derived from SCOP 51800
  • family Saccharopine reductase-like (4000094)
    Rossmann-like domain: canonical parallel beta-sheet, 6 strands, order:321456; alpha+beta domain: bifurcated mixed sheet, 6 main strands, order: 321456, extra all-alpha subdomain is inserted into the psi-loop between strands 3 and 4
    Derived from SCOP 51800
  • family Dihydrodipicolinate reductase-like (4000095)
    Rossmann-like domain: parallel beta-sheet, 7 strands, order:3214567, may swap strand 7 in dimers; alpha+beta domain: mixed sheet, 4 main strands, order: 2134, psi-loop connects strands 2 and 3, may contain extra strand at the 2-edge
    Derived from SCOP 51800
  • family DXP reductoisomerase-like (4000096)
    Rossmann-like domain: parallel beta-sheet, 7 strands, order:4321567; alpha+beta domain: mixed sheet, 4 strands, order: 2134, psi-loop connects strands 2 and 3; extra C-terminal domain: 4-helical bundle, right-handed superhelix
    Derived from SCOP 51800
Domains PDB ID RegionMethodResolution
Representative SF domain (8000884)
Glyceraldehyde-3-phosphate dehydrogenase A (EC 12.1.12) (GAPDH-A).

Escherichia coli (562)

 P0A9B2 2-331

Derived from SCOP domain 29950
rasmol icon 1GAD O:0-330 X-RAY DIFFRACTION 1.8
Clustered domains rasmol icon 1DC3 A:0-330 X-RAY DIFFRACTION 2.5
rasmol icon 1DC3 B:0-330 X-RAY DIFFRACTION 2.5
rasmol icon 1DC4 A:0-330 X-RAY DIFFRACTION 2.5
rasmol icon 1DC4 B:0-330 X-RAY DIFFRACTION 2.5
rasmol icon 1DC5 A:0-330 X-RAY DIFFRACTION 2.0
rasmol icon 1DC5 B:0-330 X-RAY DIFFRACTION 2.0
rasmol icon 1DC6 A:0-330 X-RAY DIFFRACTION 2.0
rasmol icon 1DC6 B:0-330 X-RAY DIFFRACTION 2.0
rasmol icon 1GAD P:0-330 X-RAY DIFFRACTION 1.8
rasmol icon 1GAE O:0-330 X-RAY DIFFRACTION 2.17
rasmol icon 1GAE P:0-330 X-RAY DIFFRACTION 2.17
rasmol icon 1S7C A:2-331 X-RAY DIFFRACTION 2.04
rasmol icon 2VYN A:0-329 X-RAY DIFFRACTION 2.20
rasmol icon 2VYN B:0-329 X-RAY DIFFRACTION 2.20
rasmol icon 2VYN C:0-329 X-RAY DIFFRACTION 2.20
rasmol icon 2VYV A:0-329 X-RAY DIFFRACTION 2.38
rasmol icon 2VYV B:0-329 X-RAY DIFFRACTION 2.38
rasmol icon 2VYV C:0-329 X-RAY DIFFRACTION 2.38
Representative SF domain (8000923)
Glucose-6-phosphate 1-dehydrogenase (EC 11.1.49) (G6PD).
complexed with nap, so4, mutant

Leuconostoc mesenteroides (1245)

 P11411 2-485

Derived from SCOP domain 60816
rasmol icon 1H9A A:1-484 X-RAY DIFFRACTION 2.16
Clustered domains rasmol icon 1DPG A:1-484 X-RAY DIFFRACTION 2.0
rasmol icon 1DPG B:1-484 X-RAY DIFFRACTION 2.0
rasmol icon 1E77 A:1-484 X-RAY DIFFRACTION 2.69
rasmol icon 1E7M A:1-484 X-RAY DIFFRACTION 2.54
rasmol icon 1E7Y A:1-484 X-RAY DIFFRACTION 2.48
rasmol icon 1H93 A:1-484 X-RAY DIFFRACTION 2.2
rasmol icon 1H94 A:1-484 X-RAY DIFFRACTION 2.50
rasmol icon 1H9B A:1-484 X-RAY DIFFRACTION 2.4
rasmol icon 2DPG A:1-484 X-RAY DIFFRACTION 2.5
Representative SF domain (8000942)
Biliverdin reductase A precursor (EC 13.1.24) (Biliverdin-IX alpha- reductase) (BVR A)
complexed with po4

Rattus norvegicus (10116)

 P46844 8-291

Derived from SCOP domain 73823
rasmol icon 1LC0 A:8-291 X-RAY DIFFRACTION 1.20
Clustered domains rasmol icon 1GCU A:8-291 X-RAY DIFFRACTION 1.4
rasmol icon 1LC3 A:8-291 X-RAY DIFFRACTION 1.50
Representative SF domain (8000948)
Homoserine dehydrogenase (EC 11.1.3) (HDH).

Saccharomyces cerevisiae (4932)

 P31116 2-359

Derived from SCOP domain 30033
rasmol icon 1EBF A:2-359 X-RAY DIFFRACTION 2.30
Clustered domains rasmol icon 1EBF B:2-359 X-RAY DIFFRACTION 2.30
rasmol icon 1EBU A:2-359 X-RAY DIFFRACTION 2.60
rasmol icon 1EBU B:2-359 X-RAY DIFFRACTION 2.60
rasmol icon 1EBU C:2-359 X-RAY DIFFRACTION 2.60
rasmol icon 1EBU D:2-359 X-RAY DIFFRACTION 2.60
rasmol icon 1Q7G A:2-359 X-RAY DIFFRACTION 2.60
rasmol icon 1Q7G B:2-359 X-RAY DIFFRACTION 2.60
rasmol icon 1TVE A:2-359 X-RAY DIFFRACTION 3.00
rasmol icon 1TVE B:2-359 X-RAY DIFFRACTION 3.00
Representative SF domain (8000954)
Saccharopine dehydrogenase [NADP+, L-glutamate-forming] (EC 15.1.10) (Saccharopine reductase)

Magnaporthe grisea (148305)

 Q9P4R4 2-450

Derived from SCOP domain 30040
rasmol icon 1E5Q A:2-450 X-RAY DIFFRACTION 2.10
Clustered domains rasmol icon 1E5L A:2-450 X-RAY DIFFRACTION 2.40
rasmol icon 1E5L B:2-450 X-RAY DIFFRACTION 2.40
rasmol icon 1E5Q B:2-450 X-RAY DIFFRACTION 2.10
rasmol icon 1E5Q C:2-450 X-RAY DIFFRACTION 2.10
rasmol icon 1E5Q D:2-450 X-RAY DIFFRACTION 2.10
rasmol icon 1E5Q E:2-450 X-RAY DIFFRACTION 2.10
rasmol icon 1E5Q F:2-450 X-RAY DIFFRACTION 2.10
rasmol icon 1E5Q G:2-450 X-RAY DIFFRACTION 2.10
rasmol icon 1E5Q H:2-450 X-RAY DIFFRACTION 2.10
rasmol icon 1FF9 A:2-450 Some residues were not observed X-RAY DIFFRACTION 2.00
Representative SF domain (8000961)
Dihydrodipicolinate reductase (EC 13.1.26) (DHPR).
complexed with ndp

Escherichia coli (562)

 P04036 2-273

Derived from SCOP domain 30056
rasmol icon 1DIH A:2-273 X-RAY DIFFRACTION 2.2
Clustered domains

Escherichia coli K-12 (83333)

rasmol icon 1ARZ A:4-273 The ends of this domain were trimmed X-RAY DIFFRACTION 2.6

Escherichia coli K-12 (83333)

rasmol icon 1ARZ B:5-273 The ends of this domain were trimmed X-RAY DIFFRACTION 2.6

Escherichia coli K-12 (83333)

rasmol icon 1ARZ C:3-273 The ends of this domain were trimmed X-RAY DIFFRACTION 2.6

Escherichia coli K-12 (83333)

rasmol icon 1ARZ D:3-273 The ends of this domain were trimmed X-RAY DIFFRACTION 2.6
rasmol icon 1DRU A:4-273 The ends of this domain were trimmed X-RAY DIFFRACTION 2.2
rasmol icon 1DRV A:4-273 The ends of this domain were trimmed X-RAY DIFFRACTION 2.2
rasmol icon 1DRW A:2-273 X-RAY DIFFRACTION 2.2
Representative SF domain (8000978)
1-deoxy-D-xylulose 5-phosphate reductoisomerase (EC 11.1.267) (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomerase) (2-C- methyl-D-erythritol 4-phosphate synthase)

Escherichia coli (562)

 P45568 1-310

Derived from SCOP domain 104465
rasmol icon 1Q0Q A:1-310 X-RAY DIFFRACTION 1.9
Clustered domains rasmol icon 1JVS A:1-309 The ends of this domain were trimmed X-RAY DIFFRACTION 2.2
rasmol icon 1JVS B:1-309 The ends of this domain were trimmed X-RAY DIFFRACTION 2.2

Escherichia coli K-12 (83333)

rasmol icon 1K5H A:1-310 X-RAY DIFFRACTION 2.50

Escherichia coli K-12 (83333)

rasmol icon 1K5H B:1-310 X-RAY DIFFRACTION 2.50

Escherichia coli K-12 (83333)

rasmol icon 1K5H C:1-310 X-RAY DIFFRACTION 2.50
rasmol icon 1ONN A:1-310 Some residues were not observed X-RAY DIFFRACTION 2.6
rasmol icon 1ONN B:1-310 Some residues were not observed X-RAY DIFFRACTION 2.6
rasmol icon 1ONO A:1-310 Some residues were not observed X-RAY DIFFRACTION 2.50
rasmol icon 1ONO B:1-310 Some residues were not observed X-RAY DIFFRACTION 2.50
rasmol icon 1ONP A:1-310 X-RAY DIFFRACTION 2.5
rasmol icon 1ONP B:1-310 X-RAY DIFFRACTION 2.5
rasmol icon 1Q0H A:1-310 X-RAY DIFFRACTION 2.20
rasmol icon 1Q0L A:1-310 X-RAY DIFFRACTION 2.65
rasmol icon 1Q0Q B:1-310 X-RAY DIFFRACTION 1.9
rasmol icon 1T1R A:1-309 The ends of this domain were trimmed X-RAY DIFFRACTION 2.3
rasmol icon 1T1R B:1-309 The ends of this domain were trimmed X-RAY DIFFRACTION 2.3
rasmol icon 1T1S A:1-309 The ends of this domain were trimmed X-RAY DIFFRACTION 2.4
rasmol icon 1T1S B:1-309 The ends of this domain were trimmed X-RAY DIFFRACTION 2.4

Escherichia coli str. K-12 substr. W3110 (316407)

rasmol icon 2EGH A:1-309 The ends of this domain were trimmed X-RAY DIFFRACTION 2.20

Escherichia coli str. K-12 substr. W3110 (316407)

rasmol icon 2EGH B:1-309 The ends of this domain were trimmed X-RAY DIFFRACTION 2.20

Escherichia coli K-12 (83333)

rasmol icon 3ANL A:1-309 The ends of this domain were trimmed X-RAY DIFFRACTION 2.10

Escherichia coli K-12 (83333)

rasmol icon 3ANL B:1-309 The ends of this domain were trimmed X-RAY DIFFRACTION 2.10

Escherichia coli K-12 (83333)

rasmol icon 3ANM A:1-309 The ends of this domain were trimmed X-RAY DIFFRACTION 2.00

Escherichia coli K-12 (83333)

rasmol icon 3ANM B:1-309 The ends of this domain were trimmed X-RAY DIFFRACTION 2.00

Escherichia coli K-12 (83333)

rasmol icon 3ANN A:1-309 The ends of this domain were trimmed X-RAY DIFFRACTION 2.00

Escherichia coli K-12 (83333)

rasmol icon 3ANN B:1-309 The ends of this domain were trimmed X-RAY DIFFRACTION 2.00

Escherichia coli K-12 (83333)

rasmol icon 3R0I A:1-310 Some residues were not observed X-RAY DIFFRACTION 2.10

Escherichia coli K-12 (83333)

rasmol icon 3R0I B:1-310 X-RAY DIFFRACTION 2.10