Parents

  • hyperfamily Rossmann-like nucleotide-binding lobe (1100002)
    3 layer core: alpha/beta/alpha, parallel beta-sheet of 6 strands, order 321456; common region begins with strand 1 and ends with strand 6; the core is packed against the helix that, depending on a particular superfamily member, either precedes strands 1 (rare), or follows strand 6 (common)
    Derived from SCOP 51734
  • fold Canonical Rossmann fold (2000005)
    3 layers, alpha/beta/alpha, parallel beta-sheet of 6 strands, order 321456
    Derived from SCOP 51734
Go to Graph

Superfamily

superfamily D-2-hydroxyacid dehydrogenase-like (3000044)
2 Rossmann-like domains, swapped with the C-terminal helices; the numbers of strands in each domain vary between the families; the NAD-binding site is in the C-terminal domain
Derived from SCOP 51735

Children

  • family L-alanine dehydrogenase-like (4000097)
    2 similar domains: domain 1 contains parallel 6-stranded beta-sheet, order 321456; domain 2 contains 7-stranded beta-sheet, order 3214576, strand 6 is antiparallel to the rest
    Derived from SCOP 51830
  • family S-adenosylhomocystein hydrolase-like (4000098)
    2 similar domains: domain 1 contains parallel 7-stranded beta-sheet, order 3214567; domain 2 contains 8-stranded beta-sheet, order 32145876, strand 7 is antiparallel to the rest
    Derived from SCOP 51830
  • family D-lactate/D-glycerate dehydrogenase-like (4000099)
    2 similar domains: domain 1 contains 7-stranded beta-sheet, order 2134567, strand 6 is antiparallel to the rest; domain 2 contains parallel 7-stranded beta-sheet, order 3214567
    Derived from SCOP 51830
Domains PDB ID RegionMethodResolution
Representative SF domain (8000986)
Alanine dehydrogenase (EC 14.1.1).
complexed with pyr

Phormidium lapideum (32060)

 O52942 1-361

Derived from SCOP domain 30102
rasmol icon 1SAY A:1-361 X-RAY DIFFRACTION 2.1
Clustered domains rasmol icon 1PJB A:1-361 X-RAY DIFFRACTION 2.1
rasmol icon 1PJC A:1-361 X-RAY DIFFRACTION 2.00
Representative SF domain (8000995)
Adenosylhomocysteinase (EC 33.1.1) (S-adenosyl-L-homocysteine hydrolase) (AdoHcyase)
complexed with ipa, nah, noc

Homo sapiens (9606)

 P23526 3-386

Derived from SCOP domain 84616
rasmol icon 1LI4 A:3-386 X-RAY DIFFRACTION 2.01
Clustered domains rasmol icon 1A7A A:3-386 X-RAY DIFFRACTION 2.8
rasmol icon 1A7A B:3-386 X-RAY DIFFRACTION 2.8
rasmol icon 3NJ4 A:3-386 X-RAY DIFFRACTION 2.50
rasmol icon 3NJ4 B:3-386 X-RAY DIFFRACTION 2.50
rasmol icon 3NJ4 C:3-386 X-RAY DIFFRACTION 2.50
rasmol icon 3NJ4 D:3-386 X-RAY DIFFRACTION 2.50
rasmol icon 4PFJ A:3-386 X-RAY DIFFRACTION 2.301
rasmol icon 4PFJ B:6-386 The ends of this domain were trimmed X-RAY DIFFRACTION 2.301
rasmol icon 4PGF A:3-386 X-RAY DIFFRACTION 2.592
rasmol icon 4PGF B:5-386 The ends of this domain were trimmed X-RAY DIFFRACTION 2.592
rasmol icon 4YVF A:4-386 The ends of this domain were trimmed X-RAY DIFFRACTION 2.70
rasmol icon 4YVF B:4-386 The ends of this domain were trimmed X-RAY DIFFRACTION 2.70
Representative SF domain (8001002)
Formate dehydrogenase (EC 12.1.2) (NAD-dependent formate dehydrogenase) (FDH)

Pseudomonas sp. 101 (33067)

 P33160 2-375

Derived from SCOP domain 30088
rasmol icon 2NAC A:1-374 X-RAY DIFFRACTION 1.80
Clustered domains rasmol icon 2GO1 A:1-374 X-RAY DIFFRACTION 2.10
rasmol icon 2GUG A:1-374 X-RAY DIFFRACTION 2.28
rasmol icon 2GUG B:1-369 The ends of this domain were trimmed X-RAY DIFFRACTION 2.28
rasmol icon 2GUG C:1-369 The ends of this domain were trimmed X-RAY DIFFRACTION 2.28
rasmol icon 2GUG D:1-369 The ends of this domain were trimmed X-RAY DIFFRACTION 2.28
rasmol icon 2NAC B:1-374 X-RAY DIFFRACTION 1.80
rasmol icon 2NAD A:1-374 X-RAY DIFFRACTION 2.05
rasmol icon 2NAD B:1-374 X-RAY DIFFRACTION 2.05
Representative SF domain (8017543)
D-3-phosphoglycerate dehydrogenase (EC 11.1.95) (PGDH).
complexed with tar

Mycobacterium tuberculosis (1773)

 P0A544 2-315

Derived from SCOP domain 123150
rasmol icon 1YGY A:3-316 X-RAY DIFFRACTION 2.30
Representative SF domain (8017558)
D-3-phosphoglycerate dehydrogenase (EC 11.1.95) (PGDH).
complexed with nad, mutant

Escherichia coli (562)

 P0A9T0 7-326

Derived from SCOP domain 118932
rasmol icon 1SC6 A:7-326 X-RAY DIFFRACTION 2.09
Clustered domains

Escherichia coli K-12 (83333)

rasmol icon 1PSD A:7-326 X-RAY DIFFRACTION 2.75

Escherichia coli K-12 (83333)

rasmol icon 1PSD B:7-326 X-RAY DIFFRACTION 2.75
rasmol icon 1SC6 B:7-326 X-RAY DIFFRACTION 2.09
rasmol icon 1SC6 C:9-326 The ends of this domain were trimmed X-RAY DIFFRACTION 2.09
rasmol icon 1SC6 D:7-326 X-RAY DIFFRACTION 2.09
rasmol icon 1YBA A:7-326 X-RAY DIFFRACTION 2.24
rasmol icon 1YBA B:7-326 X-RAY DIFFRACTION 2.24
rasmol icon 1YBA C:7-326 X-RAY DIFFRACTION 2.24
rasmol icon 1YBA D:7-326 X-RAY DIFFRACTION 2.24
rasmol icon 2P9C A:7-326 X-RAY DIFFRACTION 2.46
rasmol icon 2P9C B:7-326 X-RAY DIFFRACTION 2.46
rasmol icon 2P9E A:7-326 X-RAY DIFFRACTION 2.60
rasmol icon 2P9E B:7-326 X-RAY DIFFRACTION 2.60
rasmol icon 2P9E C:7-326 X-RAY DIFFRACTION 2.60
rasmol icon 2P9E D:8-326 The ends of this domain were trimmed X-RAY DIFFRACTION 2.60
rasmol icon 2P9G A:7-326 X-RAY DIFFRACTION 2.80
rasmol icon 2P9G B:7-326 X-RAY DIFFRACTION 2.80
rasmol icon 2PA3 A:7-326 X-RAY DIFFRACTION 2.74