Parents

  • hyperfamily Rossmann-like nucleotide-binding lobe (1100002)
    3 layer core: alpha/beta/alpha, parallel beta-sheet of 6 strands, order 321456; common region begins with strand 1 and ends with strand 6; the core is packed against the helix that, depending on a particular superfamily member, either precedes strands 1 (rare), or follows strand 6 (common)
    Derived from SCOP 51734
  • fold Rossmann(2x2)oid (2000009)
    3 layers: a/b/a, parallel beta-sheet of 4 strands, 2134
    Derived from SCOP 53222
  • fold Canonical Rossmann fold (2000005)
    3 layers, alpha/beta/alpha, parallel beta-sheet of 6 strands, order 321456
    Derived from SCOP 51734
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Superfamily

superfamily MtdA-like (3000046)
2 domains; the superfamily region is trimmed from the first to the last common structural elements; the coenzyme-binding domain resides in the C-terminal part, its beta-sheet topology varies slightly between the families; the N-terminal domain contains mostly parallel beta-sheet and also shows topological variations
Derived from SCOP 51735

Children

  • family Aminoacid dehydrogenase-like (4000004)
    domain 1: 6-stranded beta-sheet, order: 124356, strand 2 is antiparallel to the rest; domain 2: 6-stranded canonical parallel beta-sheet, order: 321456
    Derived from SCOP 51883
  • family Methylene-tetrahydromethanopterin dehydrogenase (MtdA)-like (4000100)
    domain 1: 4-stranded parallel beta-sheet, order: 2134; domain 2: 7-stranded beta-sheet, order: 3214576, strand 6 is antiparallel to the rest
    Derived from SCOP 51883
  • family Shikimate 5-dehydrogenase (AroE)-like (4000101)
    domain 1: 6-stranded beta-sheet, order: 213564, strand 5 is antiparallel to the rest; domain 2: canonical 6-stranded parallel beta-sheet, order: 321456
    Derived from SCOP 51883
  • family FolD-like (4000102)
    domain 1: 3-stranded parallel beta-sheet, order: 213; domain 2: 5-stranded parallel beta-sheet, order: 21345
    Derived from SCOP 51883
  • family Malate oxidoreductase-like (4000103)
    domain 1: 4-stranded parallel beta-sheet, order: 2134; domain 2: 6-stranded beta-sheet, order: 3214576, strand 3 is antiparallel to the rest
    Derived from SCOP 51883
Domains PDB ID RegionMethodResolution
Representative SF domain (8001046)
Bifunctional protein mdtA [Includes: NADP-dependent methylenetetrahydromethanopterin dehydrogenase (EC 15.1.-); Methylenetetrahydrofolate dehydrogenase (EC 15.1.5)].

Methylobacterium extorquens AM1 (272630)

 P55818 2-271

Derived from SCOP domain 78216
rasmol icon 1LUA A:2-271 X-RAY DIFFRACTION 1.90
Clustered domains rasmol icon 1LU9 A:2-271 X-RAY DIFFRACTION 1.90
rasmol icon 1LU9 B:2-271 X-RAY DIFFRACTION 1.90
rasmol icon 1LU9 C:2-271 X-RAY DIFFRACTION 1.90
rasmol icon 1LUA B:2-271 X-RAY DIFFRACTION 1.90
rasmol icon 1LUA C:2-271 X-RAY DIFFRACTION 1.90
Representative SF domain (8001052)
Shikimate dehydrogenase (EC 11.1.25).

Escherichia coli (562)

 P15770 1-254

Derived from SCOP domain 86417
rasmol icon 1NYT A:1-254 X-RAY DIFFRACTION 1.50
Clustered domains rasmol icon 1NYT B:1-254 X-RAY DIFFRACTION 1.50
rasmol icon 1NYT C:1-254 X-RAY DIFFRACTION 1.50
rasmol icon 1NYT D:1-254 X-RAY DIFFRACTION 1.50
Representative SF domain (8001064)
Bifunctional protein folD [Includes: Methylenetetrahydrofolate dehydrogenase (EC 15.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 35.4.9)].

Escherichia coli K-12 (83333)

 P24186 32-288

Derived from SCOP domain 30286
rasmol icon 1B0A A:32-288 X-RAY DIFFRACTION 2.56
Representative SF domain (8001072)
Malate oxidoreductase

Thermotoga maritima MSB8 (243274)

 Q9WZ12 58-329

Derived from SCOP domain 108724
rasmol icon 1VL6 A:58-329 X-RAY DIFFRACTION 2.61
Clustered domains rasmol icon 1VL6 B:58-329 X-RAY DIFFRACTION 2.61
rasmol icon 1VL6 C:58-329 X-RAY DIFFRACTION 2.61
rasmol icon 1VL6 D:58-329 X-RAY DIFFRACTION 2.61

Thermotoga maritima (2336)

rasmol icon 2HAE A:58-329 X-RAY DIFFRACTION 3.13

Thermotoga maritima (2336)

rasmol icon 2HAE B:58-329 X-RAY DIFFRACTION 3.13

Thermotoga maritima (2336)

rasmol icon 2HAE C:58-329 X-RAY DIFFRACTION 3.13

Thermotoga maritima (2336)

rasmol icon 2HAE D:58-329 Some residues were not observed X-RAY DIFFRACTION 3.13
Representative SF domain (8001082)
L-phenylalanine dehydrogenase (EC 14.1.20).

Rhodococcus sp. (1831)

 Q59771 35-303

Derived from SCOP domain 30270
rasmol icon 1C1D A:34-302 X-RAY DIFFRACTION 1.25
Clustered domains rasmol icon 1BW9 A:34-302 X-RAY DIFFRACTION 1.5
rasmol icon 1BW9 B:434-702 X-RAY DIFFRACTION 1.5
rasmol icon 1BXG A:34-302 X-RAY DIFFRACTION 2.3
rasmol icon 1BXG B:434-702 X-RAY DIFFRACTION 2.3
rasmol icon 1C1D B:34-302 X-RAY DIFFRACTION 1.25
rasmol icon 1C1X A:34-302 X-RAY DIFFRACTION 1.40
rasmol icon 1C1X B:34-302 X-RAY DIFFRACTION 1.40