Parents

  • hyperfamily Rossmann-like nucleotide-binding lobe (1100002)
    3 layer core: alpha/beta/alpha, parallel beta-sheet of 6 strands, order 321456; common region begins with strand 1 and ends with strand 6; the core is packed against the helix that, depending on a particular superfamily member, either precedes strands 1 (rare), or follows strand 6 (common)
    Derived from SCOP 51734
  • fold 6PGDH C-terminal helical region-like (2000006)
    not a true fold: inherited from old scop, it varies greatly between the members; to be obsoleted in future
    Derived from SCOP 48178
  • fold 6PGDH-type extended Rossmann fold (2000154)
    3 layer alpha/beta/alpha, mixed beta-sheet of 8 strands, order 32145678, strands 7 and 8 are parallel to each other and antiparallel to the rest
Go to Graph

Superfamily

superfamily 6-phosphogluconate dehydrogenase-like (3000048)
Superfamily region spans from the first common strands to the last common helix, 8-stranded beta-sheet, order:32145678, strands 7 and 8 are parallel to each other and antiparallel to the rest
Derived from SCOP 51735

Children

  • family Hydroxyisobutyrate dehydrogenase/6-phosphogluconate dehydrogenase-like (4000072)
    extra C-terminal helices form dimerisation subdomain; in some proteins this region is duplicated and the repeated regions are similarly packed as in the dimer
    Derived from SCOP 51868
  • family FNO-like (4000104)
    contains additional short C-terminal strand contributing to the dimerisation interface
    Derived from SCOP 51868
  • family Mannitol 2-dehydrogenase-like (4000105)
    structure comprises two domains and is similar to the Glycerol-3-phosphate dehydrogenase-like subunit structure, but is decorated with additional structural elements
    Derived from SCOP 51868
  • family Ketol-acid reductoisomerase (KARI)-like (4000106)
    extra C-terminal helices form dimerisation subdomain, where the different subunits interlock; in some proteins this region is duplicated and the repeated regions are similarly packed as in the dimer, forming a figure-8 knot
    Derived from SCOP 51868
  • family L-3-hydroxyacyl CoA dehydrogenase (HCDH)-like (4000107)
    extra C-terminal helices form dimerisation subdomain; in some proteins this region is duplicated and the repeated regions are similarly packed as in the dimer
    Derived from SCOP 51868
  • family MTH1747-like (4000108)
    dimerises via the common long helix, like many other families, but differs in the arrangement of extra C-terminal helices
    Derived from SCOP 51868
  • family UDP-glucose/GDP-mannose dehydrogenase-like (4000109)
    3 domains domain 1: coenzyme-binding domain; domain 2: dimerisation domain, in whichsegment-swapping observed in some proteins; domain 3: substrate-binding domain of the adenine nucleotide alpha-hydrolase-like fold, parallel beta-sheet, order:32145
    Derived from SCOP 51868
  • family Opine dehydrogenase (ODH)-like (4000110)
    structure comprises two domains and is similar to the Glycerol-3-phosphate dehydrogenase-like subunit structure
    Derived from SCOP 51868
  • family Glycerol-3-phosphate dehydrogenase-like (4000111)
    subunit structure comprises two domains, the C-terminal domain is multihelical and provides dimerisation interface distinct from other families
    Derived from SCOP 51868
  • family Ketopantoate reductase (PanE)-like (4000112)
    structure comprises two domains and is similar to the Glycerol-3-phosphate dehydrogenase-like subunit structure
    Derived from SCOP 51868
  • family Pyrroline-5-carboxylate reductase (ProC)-like (4000113)
    2 domains, the C-terminal dimerisation domain is multihelical with interlocking subunit interface, like in type I KARI proteins
    Derived from SCOP 51868
  • family HMD-like (4000114)
    2 domains, the N-terminal Rossmann-like domain binds a different cofactor and lacks the ADP-binding motif; domain 2 is multihelical dimerisation domain; the connecting helix is broken in two pieces, providing a hinge between the domains
    Derived from SCOP 51868
  • family Prephenate dehydrogenase (TyrA)-like (4000115)
    2 domains, the C-terminal dimerisation domain is multihelical with interlocking subunit interface, distinct from ProC and type I KARI
    Derived from SCOP 51868
  • family TM1727-like (4000116)
    dimerises via the common long helix, like many other families, but differs in the arrangement of extra C-terminal helices
    Derived from SCOP 51868
Domains PDB ID RegionMethodResolution
Representative SF domain (8001098)
Putative uncharacterized protein

Archaeoglobus fulgidus (2234)

 O29370 1-203

Derived from SCOP domain 66478
rasmol icon 1JAY A:1-203 X-RAY DIFFRACTION 1.65
Clustered domains rasmol icon 1JAX A:1-203 X-RAY DIFFRACTION 1.80
rasmol icon 1JAX B:1-203 X-RAY DIFFRACTION 1.80
rasmol icon 1JAY B:1-203 X-RAY DIFFRACTION 1.65
Representative SF domain (8001103)
3-hydroxyisobutyrate dehydrogenase
complexed with ndp

Thermus thermophilus HB8 (300852)

 Q5SLQ6 2-190

Derived from SCOP domain 130891
rasmol icon 2CVZ A:2-190 X-RAY DIFFRACTION 1.80
Clustered domains rasmol icon 1WP4 A:2-190 X-RAY DIFFRACTION 2.00
rasmol icon 1WP4 B:2-190 X-RAY DIFFRACTION 2.00
rasmol icon 1WP4 C:2-190 X-RAY DIFFRACTION 2.00
rasmol icon 1WP4 D:2-190 X-RAY DIFFRACTION 2.00
rasmol icon 2CVZ B:2-190 X-RAY DIFFRACTION 1.80
rasmol icon 2CVZ C:2-190 X-RAY DIFFRACTION 1.80
rasmol icon 2CVZ D:2-190 X-RAY DIFFRACTION 1.80
Representative SF domain (8001119)
Mannitol dehydrogenase (EC 11.1.67).
complexed with mse, nad

Pseudomonas fluorescens (294)

 O08355 21-314

Derived from SCOP domain 90393
rasmol icon 1LJ8 A:21-314 X-RAY DIFFRACTION 1.70
Clustered domains rasmol icon 1M2W A:21-314 X-RAY DIFFRACTION 1.80
rasmol icon 1M2W B:21-314 X-RAY DIFFRACTION 1.80
Representative SF domain (8001124)
Ketol-acid reductoisomerase (EC 11.1.86) (Acetohydroxy-acid isomeroreductase) (Alpha-keto-beta-hydroxylacil reductoisomerase)

Pseudomonas aeruginosa (287)

 Q9HVA2 17-217

Derived from SCOP domain 85947
rasmol icon 1NP3 A:17-217 X-RAY DIFFRACTION 2.00
Clustered domains rasmol icon 1NP3 B:17-217 X-RAY DIFFRACTION 2.00
rasmol icon 1NP3 C:17-217 X-RAY DIFFRACTION 2.00
rasmol icon 1NP3 D:17-217 X-RAY DIFFRACTION 2.00
Representative SF domain (8001136)
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial precursor (EC 11.1.35) (Short chain 3-hydroxyacyl-CoA dehydrogenase) (HCDH) (Medium and short chain L-3-hydroxyacyl-coenzyme A dehydrogenase)

Homo sapiens (9606)

 Q16836 24-238

Derived from SCOP domain 30197
rasmol icon 1F0Y A:12-226 X-RAY DIFFRACTION 1.80
Clustered domains rasmol icon 1F0Y B:12-226 X-RAY DIFFRACTION 1.80
rasmol icon 1F12 A:12-226 X-RAY DIFFRACTION 2.40
rasmol icon 1F12 B:12-226 X-RAY DIFFRACTION 2.40
rasmol icon 1F14 A:12-226 X-RAY DIFFRACTION 2.30
rasmol icon 1F14 B:12-226 X-RAY DIFFRACTION 2.30
rasmol icon 1F17 A:12-226 X-RAY DIFFRACTION 2.30
rasmol icon 1F17 B:12-226 X-RAY DIFFRACTION 2.30
rasmol icon 1IL0 A:12-226 X-RAY DIFFRACTION 2.20
rasmol icon 1IL0 B:12-226 X-RAY DIFFRACTION 2.20
rasmol icon 1LSJ A:12-226 X-RAY DIFFRACTION 2.50
rasmol icon 1LSJ B:12-226 X-RAY DIFFRACTION 2.50
rasmol icon 1LSO A:12-226 X-RAY DIFFRACTION 2.60
rasmol icon 1LSO B:12-226 X-RAY DIFFRACTION 2.60
rasmol icon 1M75 A:12-226 X-RAY DIFFRACTION 2.30
rasmol icon 1M75 B:12-226 X-RAY DIFFRACTION 2.30
rasmol icon 1M76 A:12-226 X-RAY DIFFRACTION 2.15
rasmol icon 1M76 B:12-226 X-RAY DIFFRACTION 2.15
rasmol icon 2HDH A:12-226 X-RAY DIFFRACTION 2.20
rasmol icon 2HDH B:12-226 X-RAY DIFFRACTION 2.20
rasmol icon 3HAD A:12-226 X-RAY DIFFRACTION 2.0
rasmol icon 3HAD B:12-226 X-RAY DIFFRACTION 2.0
rasmol icon 3RQS A:24-238 X-RAY DIFFRACTION 2.001
rasmol icon 3RQS B:24-238 X-RAY DIFFRACTION 2.001
Representative SF domain (8001149)
Conserved protein

Methanothermobacter thermautotrophicus (145262)

 O27779 2-184

Derived from SCOP domain 71109
rasmol icon 1I36 A:2-184 X-RAY DIFFRACTION 2.00
Clustered domains rasmol icon 1I36 B:2-184 X-RAY DIFFRACTION 2.00
Representative SF domain (8001155)
UDP-glucose 6-dehydrogenase (EC 11.1.22) (UDP-Glc dehydrogenase) (UDP-GlcDH) (UDPGDH)
complexed with gol, nad, so4, udx

Streptococcus pyogenes (1314)

 P0C0F4 1-229

Derived from SCOP domain 30213
rasmol icon 1DLI A:1-229 X-RAY DIFFRACTION 2.31
Clustered domains rasmol icon 1DLJ A:1-229 X-RAY DIFFRACTION 1.80
Representative SF domain (8001164)
Opine dehydrogenase (EC 15.1.28) (N-(1-D-carboxyethyl)-L-norvaline dehydrogenase)

Arthrobacter sp. 1C (79670)

 Q44297 4-216

Derived from SCOP domain 30214
rasmol icon 1BG6 A:4-216 X-RAY DIFFRACTION 1.8
Representative SF domain (8001170)
Glycerol-3-phosphate dehydrogenase [NAD(P)+] (EC 11.1.94) (NAD(P)H- dependent glycerol-3-phosphate dehydrogenase)

Archaeoglobus fulgidus (2234)

 O29390 1-210

Derived from SCOP domain 112776
rasmol icon 1TXG A:1-210 X-RAY DIFFRACTION 1.70
Clustered domains rasmol icon 1TXG B:1-210 X-RAY DIFFRACTION 1.70
Representative SF domain (8001177)
2-dehydropantoate 2-reductase (EC 11.1.169) (Ketopantoate reductase) (KPA reductase) (KPR)

Escherichia coli (562)

 P0A9J4 1-191

Derived from SCOP domain 68858
rasmol icon 1KS9 A:1-191 X-RAY DIFFRACTION 1.70
Clustered domains rasmol icon 1YJQ A:1-191 X-RAY DIFFRACTION 2.09
rasmol icon 1YON A:1-191 X-RAY DIFFRACTION 1.95

Escherichia coli K-12 (83333)

rasmol icon 2OFP A:1-191 X-RAY DIFFRACTION 2.30

Escherichia coli K-12 (83333)

rasmol icon 2OFP B:1-191 X-RAY DIFFRACTION 2.30
Representative SF domain (8001183)
Pyrroline-5-carboxylate reductase (EC 15.1.2).
complexed with so4

Neisseria meningitidis MC58 (122586)

 Q9K1N1 1-186

Derived from SCOP domain 145921
rasmol icon 1YQG A:1-186 X-RAY DIFFRACTION 1.90
Clustered domains rasmol icon 2AG8 A:1-186 X-RAY DIFFRACTION 2.10
Representative SF domain (8001190)
5,10-methenyltetrahydromethanopterin hydrogenase (EC 112.98.2) (H(2)- forming N(5),N(10)-methylenetetrahydromethanopterin dehydrogenase) (N(5),N(10)-methenyltetrahydromethanopterin hydrogenase) (H(2)- dependent methylene-H(4)MPT dehydrogenase)

Methanocaldococcus jannaschii (2190)

 Q58194 1-276

Derived from SCOP domain 127640
rasmol icon 2B0J A:1-276 X-RAY DIFFRACTION 1.75
Clustered domains rasmol icon 3DAF A:1-276 X-RAY DIFFRACTION 1.75
rasmol icon 3DAG A:1-276 X-RAY DIFFRACTION 1.75
rasmol icon 3F46 A:1-276 X-RAY DIFFRACTION 1.950
rasmol icon 3F47 A:1-276 X-RAY DIFFRACTION 1.750
rasmol icon 3H65 A:1-276 X-RAY DIFFRACTION 2.150
Representative SF domain (8001196)
Prephenate dehydrogenase
complexed with nad

Aquifex aeolicus VF5 (224324)

 O67636 31-231

Derived from SCOP domain 134649
rasmol icon 2G5C B:31-231 X-RAY DIFFRACTION 1.90
Clustered domains rasmol icon 2G5C A:31-231 X-RAY DIFFRACTION 1.90
rasmol icon 2G5C C:31-231 X-RAY DIFFRACTION 1.90
rasmol icon 2G5C D:31-231 X-RAY DIFFRACTION 1.90

Aquifex aeolicus (63363)

rasmol icon 3GGG A:31-231 X-RAY DIFFRACTION 2.21

Aquifex aeolicus (63363)

rasmol icon 3GGG B:31-231 X-RAY DIFFRACTION 2.21

Aquifex aeolicus (63363)

rasmol icon 3GGG C:31-231 X-RAY DIFFRACTION 2.21

Aquifex aeolicus (63363)

rasmol icon 3GGG D:31-231 X-RAY DIFFRACTION 2.21

Aquifex aeolicus (63363)

rasmol icon 3GGO A:31-231 X-RAY DIFFRACTION 2.15

Aquifex aeolicus (63363)

rasmol icon 3GGO B:31-231 X-RAY DIFFRACTION 2.15

Aquifex aeolicus (63363)

rasmol icon 3GGO C:31-231 X-RAY DIFFRACTION 2.15

Aquifex aeolicus (63363)

rasmol icon 3GGO D:31-231 X-RAY DIFFRACTION 2.15

Aquifex aeolicus (63363)

rasmol icon 3GGP A:31-231 X-RAY DIFFRACTION 2.25

Aquifex aeolicus (63363)

rasmol icon 3GGP B:31-231 X-RAY DIFFRACTION 2.25

Aquifex aeolicus (63363)

rasmol icon 3GGP C:31-231 X-RAY DIFFRACTION 2.25

Aquifex aeolicus (63363)

rasmol icon 3GGP D:31-231 X-RAY DIFFRACTION 2.25
Representative SF domain (8001204)
Putative uncharacterized protein
complexed with ndp

Thermotoga maritima (2336)

 Q9X250 2-184

Derived from SCOP domain 147536
rasmol icon 2I76 A:2-184 X-RAY DIFFRACTION 3.00
Clustered domains rasmol icon 2I76 B:2-184 X-RAY DIFFRACTION 3.00
Representative SF domain (8017508)
Fatty acid oxidation complex subunit alpha [Includes: Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase/3- hydroxybutyryl-CoA epimerase (EC 42.1.17) (EC 5.3.3.8) (EC 5.1.2.3); 3-hydroxyacyl-CoA dehydrogenase (EC 11.1.35)].

Pseudomonas fragi (296)

 P28793 315-519

Derived from SCOP domain 109252
rasmol icon 1WDK A:315-519 X-RAY DIFFRACTION 2.5
Clustered domains rasmol icon 1WDK B:315-519 X-RAY DIFFRACTION 2.5
rasmol icon 1WDL A:315-519 X-RAY DIFFRACTION 3.5
rasmol icon 1WDL B:315-519 X-RAY DIFFRACTION 3.5
rasmol icon 1WDM A:315-519 X-RAY DIFFRACTION 3.8
rasmol icon 1WDM B:315-519 X-RAY DIFFRACTION 3.8
rasmol icon 2D3T A:315-519 X-RAY DIFFRACTION 3.4
rasmol icon 2D3T B:315-519 X-RAY DIFFRACTION 3.4
Representative SF domain (8017573)
6-phosphogluconate dehydrogenase, decarboxylating (EC 11.1.44).
complexed with so4

Ovis aries (9940)

 P00349 2-211

Derived from SCOP domain 30190
rasmol icon 2PGD A:1-210 X-RAY DIFFRACTION 2.
Clustered domains rasmol icon 1PGN A:1-210 X-RAY DIFFRACTION 2.3
rasmol icon 1PGO A:1-210 X-RAY DIFFRACTION 2.5
rasmol icon 1PGP A:1-210 X-RAY DIFFRACTION 2.5
rasmol icon 1PGQ A:1-210 X-RAY DIFFRACTION 3.17
Representative SF domain (8017592)
Ketol-acid reductoisomerase, chloroplast precursor (EC 11.1.86) (Acetohydroxy-acid reductoisomerase) (Alpha-keto-beta-hydroxylacil reductoisomerase)

Spinacia oleracea (3562)

 Q01292 106-343

Derived from SCOP domain 30182
rasmol icon 1QMG A:106-343 X-RAY DIFFRACTION 1.6
Clustered domains rasmol icon 1QMG B:106-343 X-RAY DIFFRACTION 1.6
rasmol icon 1QMG C:106-343 X-RAY DIFFRACTION 1.6
rasmol icon 1QMG D:106-343 X-RAY DIFFRACTION 1.6
rasmol icon 1YVE I:106-343 X-RAY DIFFRACTION 1.65
rasmol icon 1YVE J:106-343 X-RAY DIFFRACTION 1.65
rasmol icon 1YVE K:106-343 X-RAY DIFFRACTION 1.65
rasmol icon 1YVE L:106-343 X-RAY DIFFRACTION 1.65