Hypothetical Evolutionary Event

Segment-swapping event within the dimeric biological unit of the UDP-glucose/GDP-mannose dehydrogenase-like family (1)

helix-swapping occurs in the dimerisation (middle) domain so that both the overall biological unit and the active site architecture are preserved


  • family UDP-glucose/GDP-mannose dehydrogenase-like (4000109)
    3 domains domain 1: coenzyme-binding domain; domain 2: dimerisation domain, in whichsegment-swapping observed in some proteins; domain 3: substrate-binding domain of the adenine nucleotide alpha-hydrolase-like fold, parallel beta-sheet, order:32145
    Derived from SCOP 51868