Hypothetical Evolutionary Event

Fold change in the lambda C1 repressor DNA-binding domain-like superfamily (11)

Change from the canonical all-alpha fold to an alpha+beta fold in the Cro-like regulatory proteins


  • fold POU domain-like (2000087)
    core: 4 helices, folded leaf, closed
    Derived from SCOP 47412
  • fold Lambda cro protein-like (2000131)
    beta-alpha(3)-beta(2); 2 layers: a/b; antiparallel beta-sheet, order 123; the three helices retain similar arrangement to the first three helices of the p22 cro protein-like fold, including HTH motif