Hypothetical Evolutionary Event

Duplication-fusion-deletion in the Ketol-acid reductoisomerase (KARI)-like family (3)

Event converts a KARI type I dimer into a single-chain KARI type II monomer with the redundant NAD-binding domain deleted

Nodes

  • family Ketol-acid reductoisomerase (KARI)-like (4000106)
    extra C-terminal helices form dimerisation subdomain, where the different subunits interlock; in some proteins this region is duplicated and the repeated regions are similarly packed as in the dimer, forming a figure-8 knot
    Derived from SCOP 51868