Hypothetical Evolutionary Event

Possible segment-swapping event within the dimeric biological unit relating MTH1747-like and TM1727-like families (5)

helix-swapping occurs in the dimerisation domain so that both the overall biological unit and the active site architecture are preserved

Nodes

  • family MTH1747-like (4000108)
    dimerises via the common long helix, like many other families, but differs in the arrangement of extra C-terminal helices
    Derived from SCOP 51868
  • family TM1727-like (4000116)
    dimerises via the common long helix, like many other families, but differs in the arrangement of extra C-terminal helices
    Derived from SCOP 51868