## Folds

- fold DRBD-type 3-helical bundle (2000000)

3-helices, bundle, up-and down anticlockwise topology, closed or partly opened, right-handed twist

Derived from SCOP 46688 - fold GroES-like (2000001)

contains barrel, partly opened, n*=4, S*=8, meander

Derived from SCOP 50128 - fold Globin-like (2000002)

core: 6 helices, folded leaf, partly opened

Derived from SCOP 46457 - fold Supersandwich (2000003)

sandwich, 18 strands in 2 sheets

Derived from SCOP 49993 - fold EF/AMT-type beta(6)-barrel (2000004)

barrel, closed, n=6, S=10, greek-key; antiparallel sheet, clockwise order: 143256

Derived from SCOP 50464 - fold Canonical Rossmann fold (2000005)

3 layers, alpha/beta/alpha, parallel beta-sheet of 6 strands, order 321456

Derived from SCOP 51734 - fold 6PGDH C-terminal helical region-like (2000006)

not a true fold: inherited from old scop, it varies greatly between the members; to be obsoleted in future

Derived from SCOP 48178 - fold SD/FR insert domain-like fold (2000007)

beta(2)-alpha-beta-alpha(n)-beta-alpha(n)-beta; antiparallel beta-sheet, order: 21543, folded into half-barrel and capped at both ends with helices

Derived from SCOP 56424 - fold LDH C-terminal subdomain-like fold (2000008)

alpha-beta(3)-alpha, meander beta-sheet twisted into a half-barrel, order 123, with helices packed at the opposite ends

Derived from SCOP 56326 - fold Rossmann(2x2)oid (2000009)

3 layers: a/b/a, parallel beta-sheet of 4 strands, 2134

Derived from SCOP 53222 - fold FMT/AAG-type beta(6)-barrel (2000011)

barrel, open, n*=6, S*=10, greek-key; antiparallel beta-sheet, clockwise order: 125436

Derived from SCOP 50485 - fold Di-heme elbow (2000013)

mini-fold of two helical CxxCH motifs, covalently attached to a stack of two heme groups

Derived from SCOP 48694 - fold Ferredoxin-like (2000014)

beta-alpha-beta(2)-alpha-beta; 2 layers, a/b; antiparallel beta-sheet, order: 4132

Derived from SCOP 54861 - fold TPM/PMT domain-like (2000015)

3 layers, a/b/a; parallel sheet of 5 strands, order 51423

Derived from SCOP 159501 - fold Rossmann(2x3)oid (Flavodoxin-like) (2000016)

3 layers, a/b/a, parallel beta-sheet of 5 strand, order 21345

Derived from SCOP 52171 - fold Folate-binding halfdomain-like (2000017)

beta(2)-alpha-beta(3)-alpha; 2 layers, alpha/beta, antiparallel beta-sheet, order: 12543

Derived from SCOP 103024 - fold Glutamyl tRNA-reductase dimerization domain (2000018)

6 helices, homodimer of 3-helical domains

Derived from SCOP 69074 - fold Voltage-gated potassium channels (2000019)

oligomeric transmembrane alpha-helical proteins

Derived from SCOP 81325 - fold GSR C-terminal domain-like (2000020)

extended variant of SufE/NifU-like fold: beta(5)-alpha(3), 2 layers, a/b; antiparallel beta-sheet, order 12543

Derived from SCOP 55423 - fold FAD/NAD(P)-binding domain (2000021)

core: 3 layers, b/b/a, central parallel beta-sheet of 5 strands, order 32145, top antiparallel beta-sheet of 3 strands, meander

Derived from SCOP 51904 - fold Formyltransferase-type (2000023)

3 layers: a/b/a, mixed beta-sheet of 7 strands, order 3214567, strand 6 is antiparallel to the rest

Derived from SCOP 53327 - fold Thioredoxin fold (2000024)

core: 3 layers, a/b/a, mixed beta-sheet of 4 strands, order: 2134, strand 3 is antiparallel to the rest

Derived from SCOP 52832 - fold Rossmann(3x2)oid (2000025)

core: 3 layers, a/b/a , parallel beta-sheet of 5 strands, order 32145

Derived from SCOP 52373 - fold Flavoreductase insert-domain like (2000026)

beta(4)-alpha-beta; 2 layers, a/b; antiparallel beta-sheet, order: 51432

Derived from SCOP 54372 - fold ClpP-type beta-alpha superhelix (2000027)

core: 4 turns of (beta-beta-alpha)n right-handed superhelix, capped at C-end by an antiparallel beta-strand

Derived from SCOP 52095 - fold HI0933-type beta(6)-barrel (2000028)

barrel, closed, n=6, S=12, greek-key; clockwise order: 143256

Derived from SCOP 160995 - fold TrkA C-terminal domain-like (2000029)

beta-X-beta(2)-X-beta-alpha; antiparallel beta-sheet, order: 1423, folded into a half barrel and capped by helix at one end; topological similarity to the HPr-like fold

Derived from SCOP 116725 - fold Spectrin repeat-like (2000030)

3 helices, bundle, up-and down anticlockwise topology, closed, left-handed twist

Derived from SCOP 46965 - fold TIM beta/alpha-barrel (2000031)

(beta-alpha)8; parallel beta-sheet barrel, closed, n=8, S=8, strand order 12345678 (anticlockwise); the first seven superfamilies have similar phosphate-binding sites

Derived from SCOP 51350 - fold Canonical FwdE/GAPDH domain-like fold (2000032)

alpha-beta-alpha-beta(3), 2 layers, alpha/beta sandwich, mixed sheet: 2134, strand 2 is parallel to strand 1, psi-loop between strands 2 and 3

Derived from SCOP 55346 - fold S13-like H2TH domain (2000033)

array of 3-5 helices with two 'kissing' loops

Derived from SCOP 81297 - fold FAD/NAD(P)-binding domain, circularly permuted variant 1 (2000034)

core: 3 layers, b/b/a, central parallel beta-sheet of 5 strands, order 15234, top antiparallel beta-sheet of 3 strands, meander

Derived from SCOP 51904 - fold GDI isoprenoid-binding domain-like (2000035)

5 helices, array, two kissing loops

Derived from SCOP 51904 - fold Long alpha-hairpin (2000036)

2 helices, antiparallel left-handed coiled-coil

Derived from SCOP 46556 - fold Class II aaRS/BPL domain-like (2000038)

core: beta-X-beta(2)-alpha-beta(4); mixed, mostly antiparallel beta-sheet, order 1237654, strands 1 and 2 are parallel to each other

Derived from SCOP 55680 - fold P-loop containing nucleoside triphosphate hydrolases (2000039)

3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes

Derived from SCOP 52539 - fold PRTase-like (2000040)

3 layers, a/b/a, mixed beta-sheet of 6 strands, order 321456, strand 3 is antiparallel to the rest

Derived from SCOP 53270 - fold TNF-like (2000041)

sandwich, 10 strands in 2 sheets, jelly-roll

Derived from SCOP 49841 - fold GyrI-type alpha(2),beta(6)-barrel (2000042)

duplication of beta-alpha-beta(2) motif: antiparallel beta sheet forms barrel (n=6, S=12), strand order 132564 (anticlockwise)

Derived from SCOP 55135 - fold FadR effector domain-like (2000043)

core: 6 helices: closed bundle, greek-key, internal pseudo twofold symmetry, mirror topology to the DEATH domain-like fold

Derived from SCOP 48007 - fold DtxR dimerization domain-like (2000044)

3 helices, arranged into a bowl-like structure; forms a compact homodimer around a single hydrophobic core

Derived from SCOP 47978 - fold Resolvase-like (2000045)

Core: 3 layers: a/b/a, mixed beta-sheet of 5 strands, order 21345, strand 5 is antiparallel to the rest

Derived from SCOP 53040 - fold Protein kinase-like (PK-like) (2000046)

consists of two alpha+beta subdomains that sandwich the ATP binding site

Derived from SCOP 56111 - fold Profilin-like (2000047)

core: beta(2)-alpha(n)-beta(3); antiparallel beta-sheet, order: 21543, 2 layers: a/b; extra N-terminal and/or C-terminal helices form third layer

Derived from SCOP 55769 - fold Double-stranded beta-helix (2000048)

one turn of helix is made by two pairs of antiparallel strands linked with short turns has appearance of a sandwich of distinct architecture and jelly-roll topology

Derived from SCOP 51181 - fold GATA zinc finger-like (2000049)

contains a beta-hairpin between the two pairs of zinc ion ligands and one or more turns of helix at the C-terminus

Derived from SCOP 57715 - fold DEATH domain-like (2000050)

6 helices: closed bundle, greek-key, internal pseudo twofold symmetry; mirror topology to the FadR effector domain-like fold

Derived from SCOP 47985 - fold Immunoglobulin-like beta-sandwich (2000051)

sandwich, 7 strands in 2 sheets, greek-key some members of the fold have additional strands

Derived from SCOP 48725 - fold Chorismate lyase-like (2000052)

duplication of alpha(2)-beta(3) motif, antiparallel beta sheet, order 123654

Derived from SCOP 64287 - fold Cytochrome b5-like (2000053)

beta-alpha-beta(2)-alpha(1,2)-(beta)-alpha(2)-beta, 3 layers: a/b/a, antiparallel beta-sheet, order: 1532(4)

Derived from SCOP 55855 - fold Urocanase catalytic domain-like (2000054)

alpha(2)-beta(3)-X-beta-alpha(2)-beta-alpha-beta-alpha-beta(2)-alpha, X is the insertion of a Rossmann-like domain; 3 layers, a/b/a; mixed beta-sheet, order:21378645, strands 2, 4 and 8 are antiparallel to the rest

Derived from SCOP 111325 - fold Fpg N-terminal domain-like (2000055)

pseudobarrel, capped on both ends by alpha-helices

Derived from SCOP 81625 - fold NDP Glycotransferase-like (2000056)

3 layers: a/b/a, mixed beta-sheet of 7 strands, order 3214657, strand 6 is antiparallel to the rest

Derived from SCOP 53447 - fold NosL/MerB-like (2000057)

unusual fold, comprises two structural repeats of beta(2)-alpha-beta motifs, forming separate beta-sheets, probable duplication

Derived from SCOP 160386 - fold FPGS-type ribokinase-like fold (2000058)

core: 3 layers: a/b/a, mixed beta-sheet of 8 strands, order 21345678, strand 7 is antiparallel to the rest

Derived from SCOP 53612 - fold SBP2HA-like (2000060)

hypothetical single-domain ancestral fold of type 2 solute binding proteins;

3 layers, a/b/a; mixed beta-sheet of 5 strands, order 21354, strand 5 is antiparallel to the rest

Derived from SCOP 53849 - fold Single-stranded right-handed beta-helix (2000062)

superhelix turns are made of parallel beta-strands and (short) turns

Derived from SCOP 51125 - fold Tetracyclin repressor C-terminal domain-like (2000063)

multihelical ligand-binding and dimerisation domain

Derived from SCOP 48497 - fold Galactose-binding domain-like (2000064)

sandwich, 9 strands in 2 sheets, jelly-roll

Derived from SCOP 49784 - fold HAND domain of the nucleosome remodeling ATPase ISWI (2000065)

4 helices, irregular array

Derived from SCOP 101223 - fold GHKL domain-like (2000066)

2 layers: alpha/beta; 8-stranded mixed beta-sheet, order: 87126345, strands 1 and 7 are parallel to each other

Derived from SCOP 55873 - fold Ribonuclease H-like motif (2000067)

2 layers: a/b, mixed beta-sheet of 5 strands, order 32145, strand 2 is antiparallel to the rest; usually followed by one or more helices forming a third layer on the other side of the beta-sheet or swapping between different domains

Derived from SCOP 53066 - fold DCoH-like (2000068)

beta(2)-alpha-beta(2)-alpha, 2 layers, alpha/beta; antiparallel beta-sheet, order 1243

Derived from SCOP 55247 - fold ATP-grasp platform-like (2000069)

beta(3)-alpha-beta(2); 2 layers, a/b; antiparallel beta-sheet, order: 32145

Derived from SCOP 56058 - fold Pili subunit-like (2000070)

alpha-beta(4); 2 layers, a/b, helix is packed along the strands of antiparallel beta-sheet, order 1234, meander

Derived from SCOP 54522 - fold Nudix (2000071)

beta(3)-alpha-beta(3)-alpha, 3 layers: alpha/beta/alpha, mixed beta-sheet, order: 6(2,3)154, strands 1 and 5 are parallel to each other; contains bifurcation: strands 2 and 3 both H-bond to strands 1; topological similarity to beta-grasp motif

Derived from SCOP 55810 - fold Ribosomal protein S5 domain 2-like (2000072)

core: beta(3)-alpha-beta-alpha, 2 layers: alpha/beta, mixed beta sheet, order: 1243, strand 2 is antiparallel to the rest; psi-loop between strands 2 and 3; left-handed crossover between strands 3 and 4

Derived from SCOP 54210 - fold RIFT-type beta(6)-barrel (2000073)

barrel, closed, n=6, S=10, greek-key; antiparallel beta-sheet, order 125436 (anticlockwise)

Derived from SCOP 50412 - fold alpha/beta-Hydrolases (2000076)

core: 3 layers, a/b/a, mixed beta-sheet of 8 strands, order 12435678, strand 2 is antiparallel to the rest

Derived from SCOP 53473 - fold Restriction endonuclease-like (2000077)

alpha-beta(3)-alpha-beta; 3 layers, a/b/a, mixed beta-sheet, order: 1234, strands 2 is antiparallel to the rest

Derived from SCOP 52979 - fold FPGS C-terminal domain-like (2000079)

3 layers: a/b/a, mixed beta-sheet of 6 strands, order 126345, strand 1 is antiparallel to the rest

Derived from SCOP 53243 - fold Hemerythrin-type up-and-down 4-helical bundle (2000080)

4 helices, bundle, up-and down anticlockwise topology, closed or partly opened, left-handed twist

Derived from SCOP 47161 - fold Type II GAT domain-like (2000081)

beta-alpha-beta(2)-alpha-beta(7)-alpha-beta(3); 4 layers: alpha/beta/beta/alpha, 13 strands in two antiparallel beta-sheets; S1 order: 3241A9B; S2 order: 5678CD

Derived from SCOP 56234 - fold MoeB-like (2000082)

3 layers: a/b/a, mixed beta-sheet of 8 strands, order 32145678, strands 6 and 8 are antiparallel to the rest

Derived from SCOP 69571 - fold Trypsin-type beta(6)-barrel (2000083)

barrel, closed, n=6, S=8, greek-key; antiparallel beta-sheet, order: 123654 (clockwise)

Derived from SCOP 50493 - fold Sec63 N-terminal domain-like (2000084)

6-7 helices, irregular array of short and longer helices, one central helix

Derived from SCOP 158701 - fold alpha-alpha superhelix (2000085)

multihelical, 2 (curved) layers: alpha/alpha, right-handed superhelix

Derived from SCOP 48370 - fold POU domain-like (2000087)

core: 4 helices, folded leaf, closed

Derived from SCOP 47412 - fold Methyltransferase-like (2000088)

core: 3 layers, a/b/a, mixed beta-sheet of 7 strands, order 3214576, strand 7 is antiparallel to the rest

Derived from SCOP 53334 - fold Concanavalin-like (2000089)

sandwich, 12-14 strands in 2 sheets, complex topology

Derived from SCOP 49898 - fold SH3-like barrel (2000090)

barrel, partly opened, n*=4, S*=8, meander the last strand is interrupted by a turn of 3-10 helix

Derived from SCOP 50036 - fold Thiolase-like (2000091)

consists of two similar subdomains related by pseudo dyad; 5 layers: a/b/a/b/a, two similar mixed beta-sheet of 5 strands each, order: 32451, strand 5 is antiparallel to the rest

Derived from SCOP 53900 - fold CBS-domain pair (2000093)

duplication: tandem repeat of two beta-X-beta-alpha-beta(2)-alpha motifs of similar sequences, 4 layers: a/b/b/a

Derived from SCOP 54630 - fold STAT-type 4-helical bundle (2000094)

4 helices, bundle, left-handed twist, right-handed superhelix

Derived from SCOP 47654 - fold MgtE membrane domain-like (2000095)

5 transmembrane helices, bundle, right-handed twist

Derived from SCOP 161092 - fold HPr-like (2000096)

beta-alpha-beta(2)-alpha-beta-alpha, 2 layers: a/b, antiparallel sheet 1423

Derived from SCOP 55593 - fold beta-Grasp (2000097)

core: beta(2)-alpha-beta(2), 2 layers, a/b; mixed beta-sheet, order: 2143, strands 1 and 4 are parallel to each other

Derived from SCOP 54235 - fold Creatinase/aminopeptidase catalytic domain-like (2000099)

duplication: composed of two very similar alpha(2)-beta(3) units related by a pseudo twofold axis; unusual pairing of the two beta-sheets at a "wrong" positive angle and few H-bonds between the edge strands

Derived from SCOP 55919 - fold OB-fold (2000100)

beta(5)-barrel, closed or partly opened n=5, S=10 or S=8, greek-key; mixed beta-sheet, order 12354 (anticlockwise), strands 3 and 5 are parallel to each other

Derived from SCOP 50198 - fold Mor dimerisation domain-like (2000101)

monomer: alpha(2)-beta; dimer: 4-helical bundle, right-hand twist, capped at one end by beta-ribbon - fold Dimerisation interlock (2000104)

dimer of alpha-alpha V-shaped units interlocked together with the formation of a 4-helical bundle; !! there are two different possible orientations of one V unit relative the other V unit that currently are not distinguished here !!

Derived from SCOP 47405 - fold PROX1 subdomain-type 4-helical bundle (2000105)

4 helices, bundle: up-and-down anticlockwise topology, right-hand twist, diamond cross-section, diagonal contact between helices 1 and 3; pseudo twofold symmetry - fold Circularly permuted folate-binding halfdomain-like (2000106)

beta-alpha-beta(3)-alpha-beta; 2 layers, alpha/beta, antiparallel beta-sheet, order: 51432

Derived from SCOP 103024 - fold Tetrapyrrole methylase C-terminal lobe-like (2000107)

3 layers, a/b/a; mixed sheet of 5 strands, order 12534, strands 4 & 5 are antiparallel to the rest

Derived from SCOP 53789 - fold Enolase N-terminal domain-like (2000109)

beta(3)-alpha(3); 2 layers, a/b; meander antiparallel beta-sheet, order: 123, packed against a 3-helical bundle

Derived from SCOP 54825 - fold YejL-like interlock (2000110)

6 helices, intertwined dimer of three-helical units, bundle

Derived from SCOP 158650 - fold FUR dimerisation domain-like (2000111)

dimer of beta(2)-alpha-beta units; mixed beta-sheet, order 213, strand 2 is antiparallel to the rest; forms a single beta-sheet in the dimer with antiparallel H-bonding of strands 3 and 3' - fold Rubredoxin-like (2000112)

metal ion-binding fold comprising two beta-hairpins; each hairpin contains at its tip two metal ion-coordinating residues, usually, cysteines.

Derived from SCOP 57769 - fold Nucleotidyltransferase-like (2000113)

to be split into different fold variants; core: alpha-beta-turn-beta-X-beta-(alpha); mixed beta-sheet, order: 123, strand 1 is antiparallel to the rest

Derived from SCOP 81302 - fold Histone-fold (2000114)

core: 3 helices; long middle helix is flanked at each end with shorter helices

Derived from SCOP 47112 - fold GltS central domain-like (2000115)

3 layers, a/b/a; parallel beta-sheet, order 15432; probable rudiment form of a beta/alpha(8) barrel, resulted from the deletion of the most of the N-terminal half - fold SAM domain-like (2000117)

4-5 helices; bundle of two orthogonally packed alpha-hairpins; DNA- and protein-interacting domain

Derived from SCOP 47768 - fold PH domain-like beta(6)-barrel (2000118)

barrel, partly opened; n*=6, S*=12; meander; capped by the C-terminal alpha-helix

Derived from SCOP 50728 - fold Frataxin-like (2000119)

alpha-beta(5)-alpha; 2 layers: alpha/beta; meander antiparallel sheet, order 12345

Derived from SCOP 55382 - fold Pair of EF Hands-like (2000120)

core: 4 helices; open array of 2 alpha-hairpins

Derived from SCOP 47472 - fold SMAD/FHA domain-like (2000121)

sandwich; 11 strands in 2 sheets; greek-key

Derived from SCOP 49878 - fold E2 binding domain-like (2000122)

beta-alpha-beta(2)-X-beta(2), 2 layers, a/b; antiparallel beta-sheet 15423

Circularly permuted variant of the ubiqutin-like topology; the C-terminal strand occupies the position of the N-terminal strand of the ubiquitin-like proteins but runs in the opposite direction - fold RAP-type triple barrel (2000124)

heterodimer of two related subunits; forms two similar barrels, n=8, S=10 each, which are fused together with the formation of a third barrel, n=6, S=8

Derived from SCOP 50915 - fold RRF domain-like (2000125)

alpha-beta(2)-alpha-beta(2); 2 layers, a/b; antiparallel beta-sheet, order: 1243

Derived from SCOP 55185 - fold Mu transposase-type beta(6)-barrel (2000126)

barrel; n=6, S=8, greek-key; antiparallel beta-sheet, clockwise order: 145632

Derived from SCOP 50609 - fold CycX/PrpD domain-like (2000127)

6 helices, up-and-down bundle, right-handed twist; the even-numbered helices are packed around a pseudo three-fold symmetry axis, surrounded by the odd-numbered helices - fold MurF/HprK domain-like (2000128)

3 layers, a/b/a; mixed beta-sheet of 5 strands, order 15432, strand 1 is antiparallel to the rest; partial similarity to the swivelling domain fold

Derived from SCOP 63417 - fold SCP-like (2000129)

alpha-beta(3)-X-beta-alpha(2)-beta-alpha; 2 layers: a/b, crossover loop X makes the third layer; antiparallel beta-sheet of 5 strands; order: 32145

Derived from SCOP 55717 - fold 'Hot dog' fold (2000130)

core: beta-alpha-beta(4); 2 layers, a/b; antiparallel beta-sheet, order 13452

Derived from SCOP 54636 - fold Lambda cro protein-like (2000131)

beta-alpha(3)-beta(2); 2 layers: a/b; antiparallel beta-sheet, order 123; the three helices retain similar arrangement to the first three helices of the p22 cro protein-like fold, including HTH motif - fold Mad2-like (2000132)

core: alpha(2)-beta(2)-alpha-beta; mixed sheet, order: 213

Derived from SCOP 56018 - fold beta-hairpin-alpha-hairpin repeat (2000134)

multiple repeats of beta(2)-alpha(2) motif

Derived from SCOP 74651 - fold Pseudo "winged helix" (2000135)

beta-alpha(2)-beta(2)-alpha; architecture is similar to that of the "winged helix" fold but topology is different

Derived from SCOP 46954 - fold beta-clip (2000138)

double-stranded ribbon sharply bent in two places; the ribbon ends form incomplete barrel; jelly-roll

Derived from SCOP 51268 - fold ZU5 domain-like (2000140)

core: beta-sandwich, 8 strands in 2 sheets; folded meander - fold IL8-like (2000141)

beta(3)-alpha; 2 layers, a/b; meander antiparallel beta-sheet, order: 123, helix is packed across the beta-strands

Derived from SCOP 54116 - fold SWIRM/ISPC-type 4-helical bundle (2000142)

4 helices, bundle: up-and-down clockwise topology, right-hand twist, diamond cross-section, diagonal contact between helices 2 and 4; pseudo twofold symmetry

Derived from SCOP 47740 - fold RpiR/Int-type 5-helical array (2000143)

5 helices, array; helices 1 and 5 cap the same open end of a DRBD-type 3-helical bundle - fold Canonical WHD (winged helix domain) fold (2000144)

alpha(3)-beta(2); 3-helical DRBD-type bundle, capped at one end with a beta-haipin; may contain extra beta-strand in the loop, connecting helices 1 and 2 - fold Helix-extended WHD fold (2000145)

alpha(3)-beta(2)-alpha; 3-helical DRBD-type bundle, capped at one end with a beta-haipin and helix 4 - fold Sheet-extended WHD fold (2000146)

alpha-beta(2)-alpha(2)-beta(2); 3-helical DRBD-type bundle, capped at one end with a 4-stranded beta-sheet - fold Variant WHD fold (2000147)

not a true fold: comprises different variants of WHD-like folds due to variations in sizes of the canonical WHD secondary structures and/or insertions of extra structures - fold SDR-type extended Rossmann fold (2000148)

3 layer alpha/beta/alpha, parallel beta-sheet of 7 strands, order 3214567, left-handed crossover connection between strands 6 and 7 - fold OCD-type extended Rossmann fold (2000149)

3 layer alpha/beta/alpha, parallel beta-sheet of 8 strands, order 32145867 - fold Variant FwdE/GAPDH domain-like fold (2000150)

not a true fold: different evolutionary elaborations of canonical FwdE/GAPDH domain-like fold

Derived from SCOP 55346 - fold Variant Rossmann fold (2000151)

not a true fold: other evolutionary elaborations of a canonical Rossmann fold, which are not conserved in a superfamily

Derived from SCOP 56326 - fold CoA-binding domain-type Rossmann fold (2000152)

3 layer alpha/beta/alpha, mixed, mostly parallel beta-sheet of 7 strands, order 3421567, strand 3 is antiparallel to the rest - fold Variant Rossmann(2x2)oid (2000153)

not a true fold: different evolutionary elaborations of Rossmann(2x2)oid

Derived from SCOP 53222 - fold 6PGDH-type extended Rossmann fold (2000154)

3 layer alpha/beta/alpha, mixed beta-sheet of 8 strands, order 32145678, strands 7 and 8 are parallel to each other and antiparallel to the rest - fold DAO-type FAD/NAD(P)-binding domain (2000155)

variant of FAD/NAD(P)-binding domain, in which an alpha-helix replaces the top meander beta-sheet: 3 layers, a/b/a, parallel beta-sheet of 5 strands, order 32145

Derived from SCOP 51904 - fold "Reversed" ferredoxin-like fold (2000156)

beta-alpha-beta(2)-alpha-beta; 2 layers, a/b; antiparallel beta-sheet, order: 1423

Derived from SCOP 100878 - fold UBA-type 3-helical bundle (2000157)

3-helices, bundle, up-and down clockwise topology, closed or partly opened, right-handed twist

Derived from SCOP 46928 - fold YrdC/RibB-like (2000159)

core: alpha-beta(2)-alpha-beta-alpha(2)-beta(2)-alpha-beta-alpha-beta; 3 layers, a/b/a; mixed twisted sheet of 7 strands, order: 7126354; strands 7 and 1 are parallel to each other

Derived from SCOP 55820 - fold HypF zinc finger-like (2000160)

coordinates zinc ion with two CxxC motifs, each motif is located at the N-end of a helical turn

Derived from SCOP 55820 - fold SBP2HA-like circular permuted variant 1 (2000161)

3 layers, a/b/a; mixed beta-sheet of 5 strands, order 51423, strand 1 is antiparallel to the rest

Derived from SCOP 53849 - fold Sua5 domain-like (2000162)

3 layers, a/b/a; parallel beta-sheet of 5 strands, order 51423 - fold MptD-like (2000163)

alpha(2)-beta(4); 2 layers: a/b; antiparallel beta-sheet, order: 1234, meander

Derived from SCOP 143559 - fold Canonical cyclophilin-type beta(8)-barrel (2000164)

barrel, closed; n=8, S=10; antiparallel beta-sheet, clockwise order: 12756438, complex topology with two overside connections that cross each other

Derived from SCOP 50890 - fold Cyclophilin38-type double beta-barrel (2000165)

Bifurcated beta-sheet of 9 strands folded into two conjoint barrels; barrel 1: closed; n=8, S=10; antiparallel beta-sheet, anticlockwise order: 12659348; barrel 2: closed n=6, S=10; mixed beta-sheet, clockwise order: 126578, strands 7 and 8 are parallel to each other

Derived from SCOP 50890 - fold CsrA-like (2000231)

sandwich, 10 strands in 2 sheets, intertwined dimer (segment-swapped, 5-stranded greek-key sandwich?)

Derived from SCOP 117129 - fold PDZ domain-like (2000296)

contains barrel, partly opened, n*=4, S*=8, meander, capped by alpha-helix

Derived from SCOP 50155 - fold Anticodon-binding domain-like (2000335)

3 layers: a/b/a, mixed beta-sheet of five strands, order 21345, strand 4 is antiparallel to the rest

Derived from SCOP 52953 - fold BtuC-like (2000362)

multihelical, 10 transmembrane helices; complex architecture: helices 2-5 and 7-10 are arranged into two similar interlocking structural motifs, related by pseudo two fold symmetry

Derived from SCOP 81346 - fold Galpha insert domain-like (2000428)

5 helices, folded leaf

Derived from SCOP 47894 - fold Left-handed superhelix (2000442)

core: 4-5 helices, bundle, left-handed superhelix

Derived from SCOP 47916 - fold Phosphoglycerate mutase-like (2000503)

core: 3 layers, a/b/a, mixed beta-sheet of 6 strands, order 324156, strand 5 is antiparallel to the rest

Derived from SCOP 53253 - fold FAD-binding/transporter-associated domain-like (2000573)

consists of two alpha+beta subdomains

Derived from SCOP 56175 - fold Anti-LPS factor/recA domain (2000610)

alpha-beta(3)-alpha(2), 2 layers, alpha/beta

Derived from SCOP 54751 - fold PUA domain-like (2000644)

pseudobarrel, mixed folded sheet of 5 strands, order 13452, strand 1 and 3 are parallel to each other

Derived from SCOP 88696 - fold RbfA-like (2000652)

formerly: Alpha-lytic protease prodomain-like; alpha-beta(2)-(alpha)-beta, 2 layers: alpha/beta, mixed beta-sheet, order 123, strand 1 is antiparallel to the rest

Derived from SCOP 54805 - fold ATP synthase beta-barrel domain-like (2000654)

barrel, closed, n=6, S=8, greek-key

Derived from SCOP 50614 - fold MutS domain III-like (2000721)

multihelical, consists of 2 all-alpha subdomains

Derived from SCOP 48333 - fold Obg protein C-terminal domain-like (2000732)

beta-(2)-alpha(3)-beta(2), 2 layers: beta/alpha, mixed beta-sheet: order 1234, strands 2 and 3 a parallel to each other

Derived from SCOP 102740 - fold hsp20-like chaperones (2000764)

sandwich, 8 strands in 2 sheets, greek-key

Derived from SCOP 49763 - fold CobW C-terminal domain-like (2000788)

beta-alpha-beta(4)-alpha, 2 layers: a/b, antiparallel sheet 15234, topological similarity to the HPr-like fold

Derived from SCOP 90001 - fold immunoglobulin/albumin-binding domain-like (2000831)

3 helices, bundle, up-and down clockwise topology, closed, left-handed twist; mirror topology to the spectrin-like fold

Derived from SCOP 46996 - fold Obg-fold (2000882)

this fold is formed by three glycine-rich regions inserted into a small 8-stranded beta-sandwich these regions form six left-handed collagen-like helices packed and H-bonded together

Derived from SCOP 82050 - fold ABC transporter transmembrane region-like (2000951)

multihelical: six transmembrane helices are arranged into two three-helical interlocking motifs, related by a pseudo two fold symmetry

Derived from SCOP 90122 - fold DnaJ/Hsp40 cysteine-rich domain (2000953)

metal(zinc)-bound extended beta-hairpin fold

Derived from SCOP 57937 - fold MalF P2 barrel-like (2001003)

beta-barrel (n=7, S=8); mixed, mostly antiparallel beta-sheet, order 1234567; overside loop between the parallel strands 4 and 5

Derived from SCOP 160963 - fold Antiparallel coiled-coil (2001019)

this is not a true fold, contains at least two very long antiparallel helices

Derived from SCOP 58086 - fold PEPCK/HprK-like alpha/beta barrel (2001024)

3 layers, a/b/b; mixed beta-sheet of 7 strands, order: 4312576, strands 1, 4 and 6 are antiparallel to the rest; the first five strands form a barrel-like structure with 2 helices packed on one side

Derived from SCOP 53794 - fold MutS N-terminal domain-like (2001031)

beta(2)-alpha-beta(2)-alpha-beta(2), 2 layers, alpha/beta

Derived from SCOP 55266 - fold Apolipoprotein A-I open twisted ring (2001038)

Pseudo-continuous, amphipathic alpha-helix that is punctuated by kinks at regularly spaced proline residues. The shape is similar to a twisted horseshoe.It forms tetrameric antiparallel coiled coil, closed in a circuit

Derived from SCOP 58112 - fold MetI-like (2001053)

core: 5 transmembrane helices, flattened bundle

Derived from SCOP 161097 - fold PEPCK N-terminal domain-like (2001096)

mixed beta-sheet of 8 strands, order: 14568723; topology is partly similar to that of the PEPCK C-terminal domain

Derived from SCOP 68922 - fold DNA primase core (2001110)

2 domains: (1) alpha+beta, (2) toprim alpha/beta

Derived from SCOP 56730 - fold Bromodomain-like (2001119)

4 helices, bundle, minor mirror variant of up-and-down topology

Derived from SCOP 47363 - fold Barrel-sandwich hybrid (2001151)

sandwich of half-barrel shaped beta-sheets

Derived from SCOP 51229 - fold HAD-like (2001153)

3 layers: a/b/a, parallel beta-sheet of 6 strands, order 321456

Derived from SCOP 56783 - fold LEM/SAP HeH motif (2001161)

helix-extended loop-helix, parallel helices

Derived from SCOP 63450 - fold SRP_SPBD-like (2001186)

4 helices, orthogonal array

Derived from SCOP 47445 - fold Rossmann(3x4)oid (2001244)

C-terminally extended Rossmann-fold: 3 layers, a/b/a , parallel beta-sheet of 7 strands, order 3214567

Derived from SCOP 52373 - fold Simibi-like (2001245)

3 layers: a/b/a, parallel beta-sheet of seven strands; order 3241567

Derived from SCOP 52539 - fold TsaE-like (2001246)

3 layers: a/b/a; mixed beta-sheet of 7 strands, order 3452671), strands 3 and 7 are antiparallel to the rest

Derived from SCOP 52539 - fold THEP1-like (2001247)

3 layers: a/b/a, mixed beta-sheet of 7 strands, order: 7165234, strand 3 is antiparallel to the rest; variant of RecA-like fold

Derived from SCOP 52539 - fold RecA-like basic (2001248)

3 layers: a/b/a, parallel beta-sheet of 6 strands, order:615423

Derived from SCOP 52539 - fold RecA-like classic (2001249)

3 layers: a/b/a, mixed, mostly parallel beta-sheet of 8 strands, order: 87615423, strand 7 is antiparallel to the rest

Derived from SCOP 52539 - fold Pair of reverse EF Hands-like (2001250)

core: 4 helices; open array of 2 alpha-hairpins; similar to EF-hand pair architecture with a reverse chain direction topology - fold ABC domain-like (2001251)

4 layers: a/b/a/b, the inner mixed beta-sheet of six strands, order 651432, strand 6 is antiparallel to the rest

Derived from SCOP 52539 - fold Apolipoprotein A-I half-circle (2001252)

Amphipathic alpha-helix that is punctuated by kinks at regularly spaced proline residues. It forms dimeric antiparallel coiled coil with a shape similar to a half-cirle. The N-terminus of one monomer folds into two small helices of different size that form a helical bundle with another monomer.

Derived from SCOP 58112 - fold MalF P2 linker domain-like (2001253)

alpha-beta(5); 2 layers; meander 5-stranded beta-sheet is folded into a half-barrel

Derived from SCOP 160963 - fold 3-helical meander layer (2001254)

3 transmembrane helices arranged in a single layer, meander - fold UvrA insert domain-like (2001255)

Irregular array of short alpha-helices and kissing loops; two helices are joint coaxially forming an "interrupted helix" by a beta-ribbon insertion - fold UvrA UvrB-binding domain-like (2001256)

alpha-beta-alpha-beta(2)-X-beta-alpha-beta(2); two layers: a/b; antiparallel beta sheet of six strands, order: 651423; internal pseudo twofold symmetry - fold P-loop kinase-like (2001257)

3 layers: a/b/a; parallel beta sheet of five strands, order: 23145 - fold C-teminally truncated RecA-like (2001259)

3 layers: a/b/a, parallel beta-sheet of 5 strands, order:15423

Derived from SCOP 52539 - fold G domain-like (2001260)

3 layers: a/b/a, mixed, predominantly parallel beta-sheet, order: 231456, strand 2 is antiparallel to the rest

Derived from SCOP 52539 - fold Circularly permuted G domain-like (2001261)

3 layers: a/b/a, mixed, predominantly parallel beta-sheet, order: 321465, strand 6 is antiparallel to the rest; P-loop is after strand 4

Derived from SCOP 52539 - fold RbgA C-terminal domain-like (2001262)

4-5 helices, orthogonal array - fold RsgA C-terminal domain-like (2001263)

4-5 helices, open up-and down bundle, Cys-rich Zinc-binding loop between helices 2 and 3 - fold Dynamin stalk-like bundle (2001264)

4 helices, up-and-down, right-handed twist