Protein Type

Globular proteins (1)

Fold into compact units. Soluble in aqueous solutions

Folds

  • fold DRBD-type 3-helical bundle (2000000)
    3-helices, bundle, up-and down anticlockwise topology, closed or partly opened, right-handed twist
    Derived from SCOP
  • fold GroES-like (2000001)
    contains barrel, partly opened, n*=4, S*=8, meander
    Derived from SCOP
  • fold Globin-like (2000002)
    core: 6 helices, folded leaf, partly opened
    Derived from SCOP
  • fold Supersandwich (2000003)
    sandwich, 18 strands in 2 sheets
    Derived from SCOP
  • fold EF/AMT-type beta(6)-barrel (2000004)
    barrel, closed, n=6, S=10, greek-key; antiparallel sheet, clockwise order: 143256
    Derived from SCOP
  • fold Canonical Rossmann fold (2000005)
    3 layers, alpha/beta/alpha, parallel beta-sheet of 6 strands, order 321456
    Derived from SCOP
  • fold OCD-type extended Rossmann fold (2000149)
    3 layer alpha/beta/alpha, parallel beta-sheet of 8 strands, order 32145867
    Derived from SCOP
  • fold 6PGDH C-terminal helical region-like (2000006)
    not a true fold: inherited from old scop, it varies greatly between the members; to be obsoleted in future
    Derived from SCOP
  • fold SD/FR insert domain-like fold (2000007)
    beta(2)-alpha-beta-alpha(n)-beta-alpha(n)-beta; antiparallel beta-sheet, order: 21543, folded into half-barrel and capped at both ends with helices
    Derived from SCOP
  • fold LDH C-terminal subdomain-like fold (2000008)
    alpha-beta(3)-alpha, meander beta-sheet twisted into a half-barrel, order 123, with helices packed at the opposite ends
    Derived from SCOP
  • fold Rossmann(2x2)oid (2000009)
    3 layers: a/b/a, parallel beta-sheet of 4 strands, 2134
    Derived from SCOP
  • fold FMT/AAG-type beta(6)-barrel (2000011)
    barrel, open, n*=6, S*=10, greek-key; antiparallel beta-sheet, clockwise order: 125436
    Derived from SCOP
  • fold Di-heme elbow (2000013)
    mini-fold of two helical CxxCH motifs, covalently attached to a stack of two heme groups
    Derived from SCOP
  • fold Ferredoxin-like (2000014)
    beta-alpha-beta(2)-alpha-beta; 2 layers, a/b; antiparallel beta-sheet, order: 4132
    Derived from SCOP
  • fold TPM/PMT domain-like (2000015)
    3 layers, a/b/a; parallel sheet of 5 strands, order 51423
    Derived from SCOP
  • fold YejL-like interlock (2000110)
    6 helices, intertwined dimer of three-helical units, bundle
    Derived from SCOP
  • fold Rossmann(2x3)oid (Flavodoxin-like) (2000016)
    3 layers, a/b/a, parallel beta-sheet of 5 strand, order 21345
    Derived from SCOP
  • fold Folate-binding halfdomain-like (2000017)
    beta(2)-alpha-beta(3)-alpha; 2 layers, alpha/beta, antiparallel beta-sheet, order: 12543
    Derived from SCOP
  • fold Glutamyl tRNA-reductase dimerization domain (2000018)
    6 helices, homodimer of 3-helical domains
    Derived from SCOP
  • fold GSR C-terminal domain-like (2000020)
    extended variant of SufE/NifU-like fold: beta(5)-alpha(3), 2 layers, a/b; antiparallel beta-sheet, order 12543
    Derived from SCOP
  • fold FAD/NAD(P)-binding domain (2000021)
    core: 3 layers, b/b/a, central parallel beta-sheet of 5 strands, order 32145, top antiparallel beta-sheet of 3 strands, meander
    Derived from SCOP
  • fold Formyltransferase-type (2000023)
    3 layers: a/b/a, mixed beta-sheet of 7 strands, order 3214567, strand 6 is antiparallel to the rest
    Derived from SCOP
  • fold Thioredoxin fold (2000024)
    core: 3 layers, a/b/a, mixed beta-sheet of 4 strands, order: 2134, strand 3 is antiparallel to the rest
    Derived from SCOP
  • fold Rossmann(3x2)oid (2000025)
    core: 3 layers, a/b/a , parallel beta-sheet of 5 strands, order 32145
    Derived from SCOP
  • fold Flavoreductase insert-domain like (2000026)
    beta(4)-alpha-beta; 2 layers, a/b; antiparallel beta-sheet, order: 51432
    Derived from SCOP
  • fold ClpP-type beta-alpha superhelix (2000027)
    core: 4 turns of (beta-beta-alpha)n right-handed superhelix, capped at C-end by an antiparallel beta-strand
    Derived from SCOP
  • fold HI0933-type beta(6)-barrel (2000028)
    barrel, closed, n=6, S=12, greek-key; clockwise order: 143256
    Derived from SCOP
  • fold TrkA C-terminal domain-like (2000029)
    beta-X-beta(2)-X-beta-alpha; antiparallel beta-sheet, order: 1423, folded into a half barrel and capped by helix at one end; topological similarity to the HPr-like fold
    Derived from SCOP
  • fold Spectrin repeat-like (2000030)
    3 helices, bundle, up-and down anticlockwise topology, closed, left-handed twist
    Derived from SCOP
  • fold TIM beta/alpha-barrel (2000031)
    (beta-alpha)8; parallel beta-sheet barrel, closed, n=8, S=8, strand order 12345678 (anticlockwise); the first seven superfamilies have similar phosphate-binding sites
    Derived from SCOP
  • fold Canonical FwdE/GAPDH domain-like fold (2000032)
    alpha-beta-alpha-beta(3), 2 layers, alpha/beta sandwich, mixed sheet: 2134, strand 2 is parallel to strand 1, psi-loop between strands 2 and 3
    Derived from SCOP
  • fold S13-like H2TH domain (2000033)
    array of 3-5 helices with two 'kissing' loops
    Derived from SCOP
  • fold FAD/NAD(P)-binding domain, circularly permuted variant 1 (2000034)
    core: 3 layers, b/b/a, central parallel beta-sheet of 5 strands, order 15234, top antiparallel beta-sheet of 3 strands, meander
    Derived from SCOP
  • fold GDI isoprenoid-binding domain-like (2000035)
    5 helices, array, two kissing loops
    Derived from SCOP
  • fold Long alpha-hairpin (2000036)
    2 helices, antiparallel left-handed coiled-coil
    Derived from SCOP
  • fold Class II aaRS/BPL domain-like (2000038)
    core: beta-X-beta(2)-alpha-beta(4); mixed, mostly antiparallel beta-sheet, order 1237654, strands 1 and 2 are parallel to each other
    Derived from SCOP
  • fold P-loop containing nucleoside triphosphate hydrolases (2000039)
    3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes
    Derived from SCOP
  • fold PRTase-like (2000040)
    3 layers, a/b/a, mixed beta-sheet of 6 strands, order 321456, strand 3 is antiparallel to the rest
    Derived from SCOP
  • fold TNF-like (2000041)
    sandwich, 10 strands in 2 sheets, jelly-roll
    Derived from SCOP
  • fold GyrI-type alpha(2),beta(6)-barrel (2000042)
    duplication of beta-alpha-beta(2) motif: antiparallel beta sheet forms barrel (n=6, S=12), strand order 132564 (anticlockwise)
    Derived from SCOP
  • fold FadR effector domain-like (2000043)
    core: 6 helices: closed bundle, greek-key, internal pseudo twofold symmetry, mirror topology to the DEATH domain-like fold
    Derived from SCOP
  • fold DtxR dimerization domain-like (2000044)
    3 helices, arranged into a bowl-like structure; forms a compact homodimer around a single hydrophobic core
    Derived from SCOP
  • fold Resolvase-like (2000045)
    Core: 3 layers: a/b/a, mixed beta-sheet of 5 strands, order 21345, strand 5 is antiparallel to the rest
    Derived from SCOP
  • fold Protein kinase-like (PK-like) (2000046)
    consists of two alpha+beta subdomains that sandwich the ATP binding site
    Derived from SCOP
  • fold Profilin-like (2000047)
    core: beta(2)-alpha(n)-beta(3); antiparallel beta-sheet, order: 21543, 2 layers: a/b; extra N-terminal and/or C-terminal helices form third layer
    Derived from SCOP
  • fold Double-stranded beta-helix (2000048)
    one turn of helix is made by two pairs of antiparallel strands linked with short turns has appearance of a sandwich of distinct architecture and jelly-roll topology
    Derived from SCOP
  • fold GATA zinc finger-like (2000049)
    contains a beta-hairpin between the two pairs of zinc ion ligands and one or more turns of helix at the C-terminus
    Derived from SCOP
  • fold DEATH domain-like (2000050)
    6 helices: closed bundle, greek-key, internal pseudo twofold symmetry; mirror topology to the FadR effector domain-like fold
    Derived from SCOP
  • fold Immunoglobulin-like beta-sandwich (2000051)
    sandwich, 7 strands in 2 sheets, greek-key some members of the fold have additional strands
    Derived from SCOP
  • fold Chorismate lyase-like (2000052)
    duplication of alpha(2)-beta(3) motif, antiparallel beta sheet, order 123654
    Derived from SCOP
  • fold Cytochrome b5-like (2000053)
    beta-alpha-beta(2)-alpha(1,2)-(beta)-alpha(2)-beta, 3 layers: a/b/a, antiparallel beta-sheet, order: 1532(4)
    Derived from SCOP
  • fold Urocanase catalytic domain-like (2000054)
    alpha(2)-beta(3)-X-beta-alpha(2)-beta-alpha-beta-alpha-beta(2)-alpha, X is the insertion of a Rossmann-like domain; 3 layers, a/b/a; mixed beta-sheet, order:21378645, strands 2, 4 and 8 are antiparallel to the rest
    Derived from SCOP
  • fold Mu transposase-type beta(6)-barrel (2000126)
    barrel; n=6, S=8, greek-key; antiparallel beta-sheet, clockwise order: 145632
    Derived from SCOP
  • fold Fpg N-terminal domain-like (2000055)
    pseudobarrel, capped on both ends by alpha-helices
    Derived from SCOP
  • fold NDP Glycotransferase-like (2000056)
    3 layers: a/b/a, mixed beta-sheet of 7 strands, order 3214657, strand 6 is antiparallel to the rest
    Derived from SCOP
  • fold NosL/MerB-like (2000057)
    unusual fold, comprises two structural repeats of beta(2)-alpha-beta motifs, forming separate beta-sheets, probable duplication
    Derived from SCOP
  • fold FPGS-type ribokinase-like fold (2000058)
    core: 3 layers: a/b/a, mixed beta-sheet of 8 strands, order 21345678, strand 7 is antiparallel to the rest
    Derived from SCOP
  • fold SBP2HA-like (2000060)
    hypothetical single-domain ancestral fold of type 2 solute binding proteins;
    3 layers, a/b/a; mixed beta-sheet of 5 strands, order 21354, strand 5 is antiparallel to the rest
    Derived from SCOP
  • fold Single-stranded right-handed beta-helix (2000062)
    superhelix turns are made of parallel beta-strands and (short) turns
    Derived from SCOP
  • fold Tetracyclin repressor C-terminal domain-like (2000063)
    multihelical ligand-binding and dimerisation domain
    Derived from SCOP
  • fold Galactose-binding domain-like (2000064)
    sandwich, 9 strands in 2 sheets, jelly-roll
    Derived from SCOP
  • fold HAND domain of the nucleosome remodeling ATPase ISWI (2000065)
    4 helices, irregular array
    Derived from SCOP
  • fold GHKL domain-like (2000066)
    2 layers: alpha/beta; 8-stranded mixed beta-sheet, order: 87126345, strands 1 and 7 are parallel to each other
    Derived from SCOP
  • fold Ribonuclease H-like motif (2000067)
    2 layers: a/b, mixed beta-sheet of 5 strands, order 32145, strand 2 is antiparallel to the rest; usually followed by one or more helices forming a third layer on the other side of the beta-sheet or swapping between different domains
    Derived from SCOP
  • fold DCoH-like (2000068)
    beta(2)-alpha-beta(2)-alpha, 2 layers, alpha/beta; antiparallel beta-sheet, order 1243
    Derived from SCOP
  • fold ATP-grasp platform-like (2000069)
    beta(3)-alpha-beta(2); 2 layers, a/b; antiparallel beta-sheet, order: 32145
    Derived from SCOP
  • fold "Reversed" ferredoxin-like fold (2000156)
    beta-alpha-beta(2)-alpha-beta; 2 layers, a/b; antiparallel beta-sheet, order: 1423
    Derived from SCOP
  • fold Pili subunit-like (2000070)
    alpha-beta(4); 2 layers, a/b, helix is packed along the strands of antiparallel beta-sheet, order 1234, meander
    Derived from SCOP
  • fold Nudix (2000071)
    beta(3)-alpha-beta(3)-alpha, 3 layers: alpha/beta/alpha, mixed beta-sheet, order: 6(2,3)154, strands 1 and 5 are parallel to each other; contains bifurcation: strands 2 and 3 both H-bond to strands 1; topological similarity to beta-grasp motif
    Derived from SCOP
  • fold Ribosomal protein S5 domain 2-like (2000072)
    core: beta(3)-alpha-beta-alpha, 2 layers: alpha/beta, mixed beta sheet, order: 1243, strand 2 is antiparallel to the rest; psi-loop between strands 2 and 3; left-handed crossover between strands 3 and 4
    Derived from SCOP
  • fold RIFT-type beta(6)-barrel (2000073)
    barrel, closed, n=6, S=10, greek-key; antiparallel beta-sheet, order 125436 (anticlockwise)
    Derived from SCOP
  • fold alpha/beta-Hydrolases (2000076)
    core: 3 layers, a/b/a, mixed beta-sheet of 8 strands, order 12435678, strand 2 is antiparallel to the rest
    Derived from SCOP
  • fold Restriction endonuclease-like (2000077)
    alpha-beta(3)-alpha-beta; 3 layers, a/b/a, mixed beta-sheet, order: 1234, strands 2 is antiparallel to the rest
    Derived from SCOP
  • fold FPGS C-terminal domain-like (2000079)
    3 layers: a/b/a, mixed beta-sheet of 6 strands, order 126345, strand 1 is antiparallel to the rest
    Derived from SCOP
  • fold Hemerythrin-type up-and-down 4-helical bundle (2000080)
    4 helices, bundle, up-and down anticlockwise topology, closed or partly opened, left-handed twist
    Derived from SCOP
  • fold Type II GAT domain-like (2000081)
    beta-alpha-beta(2)-alpha-beta(7)-alpha-beta(3); 4 layers: alpha/beta/beta/alpha, 13 strands in two antiparallel beta-sheets; S1 order: 3241A9B; S2 order: 5678CD
    Derived from SCOP
  • fold MoeB-like (2000082)
    3 layers: a/b/a, mixed beta-sheet of 8 strands, order 32145678, strands 6 and 8 are antiparallel to the rest
    Derived from SCOP
  • fold Trypsin-type beta(6)-barrel (2000083)
    barrel, closed, n=6, S=8, greek-key; antiparallel beta-sheet, order: 123654 (clockwise)
    Derived from SCOP
  • fold Sec63 N-terminal domain-like (2000084)
    6-7 helices, irregular array of short and longer helices, one central helix
    Derived from SCOP
  • fold alpha-alpha superhelix (2000085)
    multihelical, 2 (curved) layers: alpha/alpha, right-handed superhelix
    Derived from SCOP
  • fold POU domain-like (2000087)
    core: 4 helices, folded leaf, closed
    Derived from SCOP
  • fold Methyltransferase-like (2000088)
    core: 3 layers, a/b/a, mixed beta-sheet of 7 strands, order 3214576, strand 7 is antiparallel to the rest
    Derived from SCOP
  • fold Concanavalin-like (2000089)
    sandwich, 12-14 strands in 2 sheets, complex topology
    Derived from SCOP
  • fold SH3-like barrel (2000090)
    barrel, partly opened, n*=4, S*=8, meander the last strand is interrupted by a turn of 3-10 helix
    Derived from SCOP
  • fold Thiolase-like (2000091)
    consists of two similar subdomains related by pseudo dyad; 5 layers: a/b/a/b/a, two similar mixed beta-sheet of 5 strands each, order: 32451, strand 5 is antiparallel to the rest
    Derived from SCOP
  • fold CBS-domain pair (2000093)
    duplication: tandem repeat of two beta-X-beta-alpha-beta(2)-alpha motifs of similar sequences, 4 layers: a/b/b/a
    Derived from SCOP
  • fold STAT-type 4-helical bundle (2000094)
    4 helices, bundle, left-handed twist, right-handed superhelix
    Derived from SCOP
  • fold HPr-like (2000096)
    beta-alpha-beta(2)-alpha-beta-alpha, 2 layers: a/b, antiparallel sheet 1423
    Derived from SCOP
  • fold beta-Grasp (2000097)
    core: beta(2)-alpha-beta(2), 2 layers, a/b; mixed beta-sheet, order: 2143, strands 1 and 4 are parallel to each other
    Derived from SCOP
  • fold Creatinase/aminopeptidase catalytic domain-like (2000099)
    duplication: composed of two very similar alpha(2)-beta(3) units related by a pseudo twofold axis; unusual pairing of the two beta-sheets at a "wrong" positive angle and few H-bonds between the edge strands
    Derived from SCOP
  • fold OB-fold (2000100)
    beta(5)-barrel, closed or partly opened n=5, S=10 or S=8, greek-key; mixed beta-sheet, order 12354 (anticlockwise), strands 3 and 5 are parallel to each other
    Derived from SCOP
  • fold Mor dimerisation domain-like (2000101)
    monomer: alpha(2)-beta; dimer: 4-helical bundle, right-hand twist, capped at one end by beta-ribbon
    Derived from SCOP
  • fold Dimerisation interlock (2000104)
    dimer of alpha-alpha V-shaped units interlocked together with the formation of a 4-helical bundle; !! there are two different possible orientations of one V unit relative the other V unit that currently are not distinguished here !!
    Derived from SCOP
  • fold PROX1 subdomain-type 4-helical bundle (2000105)
    4 helices, bundle: up-and-down anticlockwise topology, right-hand twist, diamond cross-section, diagonal contact between helices 1 and 3; pseudo twofold symmetry
    Derived from SCOP
  • fold Circularly permuted folate-binding halfdomain-like (2000106)
    beta-alpha-beta(3)-alpha-beta; 2 layers, alpha/beta, antiparallel beta-sheet, order: 51432
    Derived from SCOP
  • fold Enolase N-terminal domain-like (2000109)
    beta(3)-alpha(3); 2 layers, a/b; meander antiparallel beta-sheet, order: 123, packed against a 3-helical bundle
    Derived from SCOP
  • fold Tetrapyrrole methylase C-terminal lobe-like (2000107)
    3 layers, a/b/a; mixed sheet of 5 strands, order 12534, strands 4 & 5 are antiparallel to the rest
    Derived from SCOP
  • fold FUR dimerisation domain-like (2000111)
    dimer of beta(2)-alpha-beta units; mixed beta-sheet, order 213, strand 2 is antiparallel to the rest; forms a single beta-sheet in the dimer with antiparallel H-bonding of strands 3 and 3'
    Derived from SCOP
  • fold Rubredoxin-like (2000112)
    metal ion-binding fold comprising two beta-hairpins; each hairpin contains at its tip two metal ion-coordinating residues, usually, cysteines.
    Derived from SCOP
  • fold Nucleotidyltransferase-like (2000113)
    to be split into different fold variants; core: alpha-beta-turn-beta-X-beta-(alpha); mixed beta-sheet, order: 123, strand 1 is antiparallel to the rest
    Derived from SCOP
  • fold Histone-fold (2000114)
    core: 3 helices; long middle helix is flanked at each end with shorter helices
    Derived from SCOP
  • fold GltS central domain-like (2000115)
    3 layers, a/b/a; parallel beta-sheet, order 15432; probable rudiment form of a beta/alpha(8) barrel, resulted from the deletion of the most of the N-terminal half
    Derived from SCOP
  • fold SAM domain-like (2000117)
    4-5 helices; bundle of two orthogonally packed alpha-hairpins; DNA- and protein-interacting domain
    Derived from SCOP
  • fold PH domain-like beta(6)-barrel (2000118)
    barrel, partly opened; n*=6, S*=12; meander; capped by the C-terminal alpha-helix
    Derived from SCOP
  • fold Frataxin-like (2000119)
    alpha-beta(5)-alpha; 2 layers: alpha/beta; meander antiparallel sheet, order 12345
    Derived from SCOP
  • fold Pair of EF Hands-like (2000120)
    core: 4 helices; open array of 2 alpha-hairpins
    Derived from SCOP
  • fold SMAD/FHA domain-like (2000121)
    sandwich; 11 strands in 2 sheets; greek-key
    Derived from SCOP
  • fold E2 binding domain-like (2000122)
    beta-alpha-beta(2)-X-beta(2), 2 layers, a/b; antiparallel beta-sheet 15423
    Circularly permuted variant of the ubiqutin-like topology; the C-terminal strand occupies the position of the N-terminal strand of the ubiquitin-like proteins but runs in the opposite direction
    Derived from SCOP
  • fold RAP-type triple barrel (2000124)
    heterodimer of two related subunits; forms two similar barrels, n=8, S=10 each, which are fused together with the formation of a third barrel, n=6, S=8
    Derived from SCOP
  • fold RRF domain-like (2000125)
    alpha-beta(2)-alpha-beta(2); 2 layers, a/b; antiparallel beta-sheet, order: 1243
    Derived from SCOP
  • fold CycX/PrpD domain-like (2000127)
    6 helices, up-and-down bundle, right-handed twist; the even-numbered helices are packed around a pseudo three-fold symmetry axis, surrounded by the odd-numbered helices
    Derived from SCOP
  • fold MurF/HprK domain-like (2000128)
    3 layers, a/b/a; mixed beta-sheet of 5 strands, order 15432, strand 1 is antiparallel to the rest; partial similarity to the swivelling domain fold
    Derived from SCOP
  • fold SCP-like (2000129)
    alpha-beta(3)-X-beta-alpha(2)-beta-alpha; 2 layers: a/b, crossover loop X makes the third layer; antiparallel beta-sheet of 5 strands; order: 32145
    Derived from SCOP
  • fold 'Hot dog' fold (2000130)
    core: beta-alpha-beta(4); 2 layers, a/b; antiparallel beta-sheet, order 13452
    Derived from SCOP
  • fold Lambda cro protein-like (2000131)
    beta-alpha(3)-beta(2); 2 layers: a/b; antiparallel beta-sheet, order 123; the three helices retain similar arrangement to the first three helices of the p22 cro protein-like fold, including HTH motif
    Derived from SCOP
  • fold Mad2-like (2000132)
    core: alpha(2)-beta(2)-alpha-beta; mixed sheet, order: 213
    Derived from SCOP
  • fold beta-hairpin-alpha-hairpin repeat (2000134)
    multiple repeats of beta(2)-alpha(2) motif
    Derived from SCOP
  • fold Pseudo "winged helix" (2000135)
    beta-alpha(2)-beta(2)-alpha; architecture is similar to that of the "winged helix" fold but topology is different
    Derived from SCOP
  • fold beta-clip (2000138)
    double-stranded ribbon sharply bent in two places; the ribbon ends form incomplete barrel; jelly-roll
    Derived from SCOP
  • fold ZU5 domain-like (2000140)
    core: beta-sandwich, 8 strands in 2 sheets; folded meander
    Derived from SCOP
  • fold IL8-like (2000141)
    beta(3)-alpha; 2 layers, a/b; meander antiparallel beta-sheet, order: 123, helix is packed across the beta-strands
    Derived from SCOP
  • fold SWIRM/ISPC-type 4-helical bundle (2000142)
    4 helices, bundle: up-and-down clockwise topology, right-hand twist, diamond cross-section, diagonal contact between helices 2 and 4; pseudo twofold symmetry
    Derived from SCOP
  • fold RpiR/Int-type 5-helical array (2000143)
    5 helices, array; helices 1 and 5 cap the same open end of a DRBD-type 3-helical bundle
    Derived from SCOP
  • fold Canonical WHD (winged helix domain) fold (2000144)
    alpha(3)-beta(2); 3-helical DRBD-type bundle, capped at one end with a beta-haipin; may contain extra beta-strand in the loop, connecting helices 1 and 2
    Derived from SCOP
  • fold Helix-extended WHD fold (2000145)
    alpha(3)-beta(2)-alpha; 3-helical DRBD-type bundle, capped at one end with a beta-haipin and helix 4
    Derived from SCOP
  • fold Sheet-extended WHD fold (2000146)
    alpha-beta(2)-alpha(2)-beta(2); 3-helical DRBD-type bundle, capped at one end with a 4-stranded beta-sheet
    Derived from SCOP
  • fold Variant WHD fold (2000147)
    not a true fold: comprises different variants of WHD-like folds due to variations in sizes of the canonical WHD secondary structures and/or insertions of extra structures
    Derived from SCOP
  • fold SDR-type extended Rossmann fold (2000148)
    3 layer alpha/beta/alpha, parallel beta-sheet of 7 strands, order 3214567, left-handed crossover connection between strands 6 and 7
    Derived from SCOP
  • fold Variant FwdE/GAPDH domain-like fold (2000150)
    not a true fold: different evolutionary elaborations of canonical FwdE/GAPDH domain-like fold
    Derived from SCOP
  • fold Variant Rossmann fold (2000151)
    not a true fold: other evolutionary elaborations of a canonical Rossmann fold, which are not conserved in a superfamily
    Derived from SCOP
  • fold CoA-binding domain-type Rossmann fold (2000152)
    3 layer alpha/beta/alpha, mixed, mostly parallel beta-sheet of 7 strands, order 3421567, strand 3 is antiparallel to the rest
    Derived from SCOP
  • fold Variant Rossmann(2x2)oid (2000153)
    not a true fold: different evolutionary elaborations of Rossmann(2x2)oid
    Derived from SCOP
  • fold 6PGDH-type extended Rossmann fold (2000154)
    3 layer alpha/beta/alpha, mixed beta-sheet of 8 strands, order 32145678, strands 7 and 8 are parallel to each other and antiparallel to the rest
    Derived from SCOP
  • fold DAO-type FAD/NAD(P)-binding domain (2000155)
    variant of FAD/NAD(P)-binding domain, in which an alpha-helix replaces the top meander beta-sheet: 3 layers, a/b/a, parallel beta-sheet of 5 strands, order 32145
    Derived from SCOP
  • fold UBA-type 3-helical bundle (2000157)
    3-helices, bundle, up-and down clockwise topology, closed or partly opened, right-handed twist
    Derived from SCOP
  • fold YrdC/RibB-like (2000159)
    core: alpha-beta(2)-alpha-beta-alpha(2)-beta(2)-alpha-beta-alpha-beta; 3 layers, a/b/a; mixed twisted sheet of 7 strands, order: 7126354; strands 7 and 1 are parallel to each other
    Derived from SCOP
  • fold HypF zinc finger-like (2000160)
    coordinates zinc ion with two CxxC motifs, each motif is located at the N-end of a helical turn
    Derived from SCOP
  • fold SBP2HA-like circular permuted variant 1 (2000161)
    3 layers, a/b/a; mixed beta-sheet of 5 strands, order 51423, strand 1 is antiparallel to the rest
    Derived from SCOP
  • fold Sua5 domain-like (2000162)
    3 layers, a/b/a; parallel beta-sheet of 5 strands, order 51423
    Derived from SCOP
  • fold MptD-like (2000163)
    alpha(2)-beta(4); 2 layers: a/b; antiparallel beta-sheet, order: 1234, meander
    Derived from SCOP
  • fold Canonical cyclophilin-type beta(8)-barrel (2000164)
    barrel, closed; n=8, S=10; antiparallel beta-sheet, clockwise order: 12756438, complex topology with two overside connections that cross each other
    Derived from SCOP
  • fold Cyclophilin38-type double beta-barrel (2000165)
    Bifurcated beta-sheet of 9 strands folded into two conjoint barrels; barrel 1: closed; n=8, S=10; antiparallel beta-sheet, anticlockwise order: 12659348; barrel 2: closed n=6, S=10; mixed beta-sheet, clockwise order: 126578, strands 7 and 8 are parallel to each other
    Derived from SCOP
  • fold CsrA-like (2000231)
    sandwich, 10 strands in 2 sheets, intertwined dimer (segment-swapped, 5-stranded greek-key sandwich?)
    Derived from SCOP
  • fold PDZ domain-like (2000296)
    contains barrel, partly opened, n*=4, S*=8, meander, capped by alpha-helix
    Derived from SCOP
  • fold Anticodon-binding domain-like (2000335)
    3 layers: a/b/a, mixed beta-sheet of five strands, order 21345, strand 4 is antiparallel to the rest
    Derived from SCOP
  • fold Galpha insert domain-like (2000428)
    5 helices, folded leaf
    Derived from SCOP
  • fold Left-handed superhelix (2000442)
    core: 4-5 helices, bundle, left-handed superhelix
    Derived from SCOP
  • fold Phosphoglycerate mutase-like (2000503)
    core: 3 layers, a/b/a, mixed beta-sheet of 6 strands, order 324156, strand 5 is antiparallel to the rest
    Derived from SCOP
  • fold FAD-binding/transporter-associated domain-like (2000573)
    consists of two alpha+beta subdomains
    Derived from SCOP
  • fold Anti-LPS factor/recA domain (2000610)
    alpha-beta(3)-alpha(2), 2 layers, alpha/beta
    Derived from SCOP
  • fold PUA domain-like (2000644)
    pseudobarrel, mixed folded sheet of 5 strands, order 13452, strand 1 and 3 are parallel to each other
    Derived from SCOP
  • fold RbfA-like (2000652)
    formerly: Alpha-lytic protease prodomain-like; alpha-beta(2)-(alpha)-beta, 2 layers: alpha/beta, mixed beta-sheet, order 123, strand 1 is antiparallel to the rest
    Derived from SCOP
  • fold ATP synthase beta-barrel domain-like (2000654)
    barrel, closed, n=6, S=8, greek-key
    Derived from SCOP
  • fold MutS domain III-like (2000721)
    multihelical, consists of 2 all-alpha subdomains
    Derived from SCOP
  • fold Obg protein C-terminal domain-like (2000732)
    beta-(2)-alpha(3)-beta(2), 2 layers: beta/alpha, mixed beta-sheet: order 1234, strands 2 and 3 a parallel to each other
    Derived from SCOP
  • fold hsp20-like chaperones (2000764)
    sandwich, 8 strands in 2 sheets, greek-key
    Derived from SCOP
  • fold CobW C-terminal domain-like (2000788)
    beta-alpha-beta(4)-alpha, 2 layers: a/b, antiparallel sheet 15234, topological similarity to the HPr-like fold
    Derived from SCOP
  • fold immunoglobulin/albumin-binding domain-like (2000831)
    3 helices, bundle, up-and down clockwise topology, closed, left-handed twist; mirror topology to the spectrin-like fold
    Derived from SCOP
  • fold Obg-fold (2000882)
    this fold is formed by three glycine-rich regions inserted into a small 8-stranded beta-sandwich these regions form six left-handed collagen-like helices packed and H-bonded together
    Derived from SCOP
  • fold DnaJ/Hsp40 cysteine-rich domain (2000953)
    metal(zinc)-bound extended beta-hairpin fold
    Derived from SCOP
  • fold MalF P2 barrel-like (2001003)
    beta-barrel (n=7, S=8); mixed, mostly antiparallel beta-sheet, order 1234567; overside loop between the parallel strands 4 and 5
    Derived from SCOP
  • fold PEPCK/HprK-like alpha/beta barrel (2001024)
    3 layers, a/b/b; mixed beta-sheet of 7 strands, order: 4312576, strands 1, 4 and 6 are antiparallel to the rest; the first five strands form a barrel-like structure with 2 helices packed on one side
    Derived from SCOP
  • fold MutS N-terminal domain-like (2001031)
    beta(2)-alpha-beta(2)-alpha-beta(2), 2 layers, alpha/beta
    Derived from SCOP
  • fold PEPCK N-terminal domain-like (2001096)
    mixed beta-sheet of 8 strands, order: 14568723; topology is partly similar to that of the PEPCK C-terminal domain
    Derived from SCOP
  • fold DNA primase core (2001110)
    2 domains: (1) alpha+beta, (2) toprim alpha/beta
    Derived from SCOP
  • fold Bromodomain-like (2001119)
    4 helices, bundle, minor mirror variant of up-and-down topology
    Derived from SCOP
  • fold Barrel-sandwich hybrid (2001151)
    sandwich of half-barrel shaped beta-sheets
    Derived from SCOP
  • fold HAD-like (2001153)
    3 layers: a/b/a, parallel beta-sheet of 6 strands, order 321456
    Derived from SCOP
  • fold LEM/SAP HeH motif (2001161)
    helix-extended loop-helix, parallel helices
    Derived from SCOP
  • fold SRP_SPBD-like (2001186)
    4 helices, orthogonal array
    Derived from SCOP
  • fold Rossmann(3x4)oid (2001244)
    C-terminally extended Rossmann-fold: 3 layers, a/b/a , parallel beta-sheet of 7 strands, order 3214567
    Derived from SCOP
  • fold Simibi-like (2001245)
    3 layers: a/b/a, parallel beta-sheet of seven strands; order 3241567
    Derived from SCOP
  • fold TsaE-like (2001246)
    3 layers: a/b/a; mixed beta-sheet of 7 strands, order 3452671), strands 3 and 7 are antiparallel to the rest
    Derived from SCOP
  • fold THEP1-like (2001247)
    3 layers: a/b/a, mixed beta-sheet of 7 strands, order: 7165234, strand 3 is antiparallel to the rest; variant of RecA-like fold
    Derived from SCOP
  • fold RecA-like basic (2001248)
    3 layers: a/b/a, parallel beta-sheet of 6 strands, order:615423
    Derived from SCOP
  • fold RecA-like classic (2001249)
    3 layers: a/b/a, mixed, mostly parallel beta-sheet of 8 strands, order: 87615423, strand 7 is antiparallel to the rest
    Derived from SCOP
  • fold Pair of reverse EF Hands-like (2001250)
    core: 4 helices; open array of 2 alpha-hairpins; similar to EF-hand pair architecture with a reverse chain direction topology
    Derived from SCOP
  • fold ABC domain-like (2001251)
    4 layers: a/b/a/b, the inner mixed beta-sheet of six strands, order 651432, strand 6 is antiparallel to the rest
    Derived from SCOP
  • fold MalF P2 linker domain-like (2001253)
    alpha-beta(5); 2 layers; meander 5-stranded beta-sheet is folded into a half-barrel
    Derived from SCOP
  • fold UvrA insert domain-like (2001255)
    Irregular array of short alpha-helices and kissing loops; two helices are joint coaxially forming an "interrupted helix" by a beta-ribbon insertion
    Derived from SCOP
  • fold UvrA UvrB-binding domain-like (2001256)
    alpha-beta-alpha-beta(2)-X-beta-alpha-beta(2); two layers: a/b; antiparallel beta sheet of six strands, order: 651423; internal pseudo twofold symmetry
    Derived from SCOP
  • fold P-loop kinase-like (2001257)
    3 layers: a/b/a; parallel beta sheet of five strands, order: 23145
    Derived from SCOP
  • fold C-teminally truncated RecA-like (2001259)
    3 layers: a/b/a, parallel beta-sheet of 5 strands, order:15423
    Derived from SCOP
  • fold G domain-like (2001260)
    3 layers: a/b/a, mixed, predominantly parallel beta-sheet, order: 231456, strand 2 is antiparallel to the rest
    Derived from SCOP
  • fold Circularly permuted G domain-like (2001261)
    3 layers: a/b/a, mixed, predominantly parallel beta-sheet, order: 321465, strand 6 is antiparallel to the rest; P-loop is after strand 4
    Derived from SCOP
  • fold RbgA C-terminal domain-like (2001262)
    4-5 helices, orthogonal array
    Derived from SCOP
  • fold RsgA C-terminal domain-like (2001263)
    4-5 helices, open up-and down bundle, Cys-rich Zinc-binding loop between helices 2 and 3
    Derived from SCOP
  • fold Dynamin stalk-like bundle (2001264)
    4 helices, up-and-down, right-handed twist
    Derived from SCOP